1. Electroanalytical Sensor Based on Gold-Nanoparticle-Decorated Paper for Sensitive Detection of Copper Ions in Sweat and Serum
- Author
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Simona Roggero, Neda Bagheri, Paolo A. Netti, Vincenzo Mazzaracchio, Stefano Cinti, Danila Moscone, Noemi Colozza, Mohammad Saraji, Fabiana Arduini, Concetta Di Natale, Bagheri, N., Mazzaracchio, V., Cinti, S., Colozza, N., Di Natale, C., Netti, P. A., Saraji, M., Roggero, S., Moscone, D., and Arduini, F.
- Subjects
Analyte ,Microfluidics ,Metal Nanoparticles ,Nanoparticle ,chemistry.chemical_element ,Nanotechnology ,Biosensing Techniques ,Standard solution ,010402 general chemistry ,01 natural sciences ,Analytical Chemistry ,law.invention ,Biosensing Technique ,law ,Ion ,Sweat ,Ions ,Filter paper ,010401 analytical chemistry ,Copper ,0104 chemical sciences ,chemistry ,Reagent ,Gold ,Atomic absorption spectroscopy - Abstract
The growth of (bio)sensors in analytical chemistry is mainly attributable to the development of affordable, effective, portable, and user-friendly analytical tools. In the field of sensors, paper-based devices are gaining a relevant position for their outstanding features including foldability, ease of use, and instrument-free microfluidics. Herein, a multifarious use of filter paper to detect copper ions in bodily fluids is reported by exploiting this eco-friendly material to (i) synthesize AuNPs without the use of reductants and/or external stimuli, (ii) print the electrodes, (iii) load the reagents for the assay, (iv) filter the gross impurities, and (v) preconcentrate the target analyte. Copper ions were detected down to 3 ppb with a linearity up to 400 ppb in standard solutions. The applicability in biological matrices, namely, sweat and serum, was demonstrated by recovery studies and by analyzing these biofluids with the paper-based platform and the reference method (atomic absorption spectroscopy), demonstrating satisfactory accuracy of the novel eco-designed analytical tool.
- Published
- 2021