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Start Over Author "Penner, Reginald M." Topic nanoscience & nanotechnology
16 results on '"Penner, Reginald M."'

1. Moving Electrons Purposefully through Single Molecules and Nanostructures: A Tribute to the Science of Professor Nongjian Tao (1963–2020)

Author

Forzani, Erica S, He, Huixin, Hihath, Joshua, Lindsay, Stuart, Penner, Reginald M, Wang, Shaopeng, and Xu, Bingqian

Subjects
Electrochemistry, Electrons, Humans, Nanostructures, Nanotechnology, Nanoscience & Nanotechnology
Abstract

Electrochemistry intersected nanoscience 25 years ago when it became possible to control the flow of electrons through single molecules and nanostructures. Many surprises and a wealth of understanding were generated by these experiments. Professor Nongjian Tao was among the pioneering scientists who created the methods and technologies for advancing this new frontier. Achieving a deeper understanding of charge transport in molecules and low-dimensional materials was the first priority of his experiments, but he also succeeded in discovering applications in chemical sensing and biosensing for these novel nanoscopic systems. In parallel with this work, the investigation of a range of phenomena using novel optical microscopic methods was a passion of his and his students. This article is a review and an appreciation of some of his many contributions with a view to the future.

Published
2020

2. Electrochemical Quantification of Glycated and Non-glycated Human Serum Albumin in Synthetic Urine

Author

Attar, Aisha M, Richardson, Mark B, Speciale, Gaetano, Majumdar, Sudipta, Dyer, Rebekah P, Sanders, Emily C, Penner, Reginald M, and Weiss, Gregory A

Subjects
Analytical Chemistry, Engineering, Chemical Sciences, Diabetes, Biosensing Techniques, Electrochemical Techniques, Enzymes, Immobilized, Equipment Design, Glycation End Products, Advanced, Humans, Models, Biological, Serum Albumin, Serum Albumin, Human, Tetrahydrofolate Dehydrogenase, Glycated Serum Albumin, human serum albumin, glycated albumin, polythiophene, iminodiacetic acid, boronic acid, dihydrofolate reductase, biosensor, Nanoscience & Nanotechnology, Chemical sciences, Physical sciences
Abstract

A polymer-based electrode capable of specific detection of human serum albumin, and its glycated derivatives, is described. The sensor is constructed from a glass microscope slide coated with a synthesized, polythiophene film bearing a protected, iminodiacetic acid motif. The electrode surface is then further elaborated to a functional biosensor through deprotection of the iminodiacetic acid, followed by metal-affinity immobilization of a specific and high-affinity, albumin ligand. Albumin was then quantified in buffer and synthetic urine via electrochemical impedance spectroscopy. Glycated albumin was next bound to a boronic acid-modified, single-cysteine dihydrofolate reductase variant to quantify glycation ratios by square-wave voltammetry. The platform offers high sensitivity, specificity, and reproducibility in an inexpensive arrangement. The detection limits exceed the requirements for intermediate-term glycemic control monitoring in diabetes patients at 5 and 1 nM for albumin and its glycated forms, respectively.

Published
2019

3. The 15th Anniversary of the U.S. National Nanotechnology Initiative

Author

Chan, Warren CW, Chhowalla, Manish, Farokhzad, Omid, Glotzer, Sharon, Gogotsi, Yury, Hammond, Paula T, Hersam, Mark C, Javey, Ali, Kagan, Cherie R, Kataoka, Kazunori, Khademhosseini, Ali, Kotov, Nicholas A, Lee, Shuit-Tong, Lee, Young Hee, Li, Yan, Millstone, Jill E, Mulvaney, Paul, Nel, Andre E, Nordlander, Peter J, Parak, Wolfgang J, Penner, Reginald M, Rogach, Andrey L, Schaak, Raymond E, Sood, Ajay K, Stevens, Molly M, Wee, Andrew TS, Weil, Tanja, Willson, C Grant, and Weiss, Paul S

Subjects
Nanoscience & Nanotechnology
Published
2018

5. The Virus Bioresistor: Wiring Virus Particles for the Direct, Label-Free Detection of Target Proteins

Author

Bhasin, Apurva, Ogata, Alana F, Briggs, Jeffrey S, Tam, Phillip Y, Tan, Ming X, Weiss, Gregory A, and Penner, Reginald M

Subjects
Data Management and Data Science, Information and Computing Sciences, Engineering, Bacteriophage M13, Biosensing Techniques, Electric Impedance, Equipment Design, Humans, Limit of Detection, Serum Albumin, Human, Virion, Bacteriophage, chemiresistor, biosensor, impedance, human serum albumin, Nanoscience & Nanotechnology
Abstract

The virus bioresistor (VBR) is a chemiresistor that directly transfers information from virus particles to an electrical circuit. Specifically, the VBR enables the label-free detection of a target protein that is recognized and bound by filamentous M13 virus particles, each with dimensions of 6 nm ( w) × 1 μm ( l), entrained in an ultrathin (∼250 nm) composite virus-polymer resistor. Signal produced by the specific binding of virus to target molecules is monitored using the electrical impedance of the VBR: The VBR presents a complex impedance that is modeled by an equivalent circuit containing just three circuit elements: a solution resistance ( Rsoln), a channel resistance ( RVBR), and an interfacial capacitance ( CVBR). The value of RVBR, measured across 5 orders of magnitude in frequency, is increased by the specific recognition and binding of a target protein to the virus particles in the resistor, producing a signal Δ RVBR. The VBR concept is demonstrated using a model system in which human serum albumin (HSA, 66 kDa) is detected in a phosphate buffer solution. The VBR cleanly discriminates between a change in the electrical resistance of the buffer, measured by Rsoln, and selective binding of HSA to virus particles, measured by RVBR. The Δ RVBR induced by HSA binding is as high as 200 Ω, contributing to low sensor-to-sensor coefficients-of-variation (

Published
2018

6. Diverse Applications of Nanomedicine.

Author

Pelaz, Beatriz, Alexiou, Christoph, Alvarez-Puebla, Ramon A, Alves, Frauke, Andrews, Anne M, Ashraf, Sumaira, Balogh, Lajos P, Ballerini, Laura, Bestetti, Alessandra, Brendel, Cornelia, Bosi, Susanna, Carril, Monica, Chan, Warren CW, Chen, Chunying, Chen, Xiaodong, Chen, Xiaoyuan, Cheng, Zhen, Cui, Daxiang, Du, Jianzhong, Dullin, Christian, Escudero, Alberto, Feliu, Neus, Gao, Mingyuan, George, Michael, Gogotsi, Yury, Grünweller, Arnold, Gu, Zhongwei, Halas, Naomi J, Hampp, Norbert, Hartmann, Roland K, Hersam, Mark C, Hunziker, Patrick, Jian, Ji, Jiang, Xingyu, Jungebluth, Philipp, Kadhiresan, Pranav, Kataoka, Kazunori, Khademhosseini, Ali, Kopeček, Jindřich, Kotov, Nicholas A, Krug, Harald F, Lee, Dong Soo, Lehr, Claus-Michael, Leong, Kam W, Liang, Xing-Jie, Ling Lim, Mei, Liz-Marzán, Luis M, Ma, Xiaowei, Macchiarini, Paolo, Meng, Huan, Möhwald, Helmuth, Mulvaney, Paul, Nel, Andre E, Nie, Shuming, Nordlander, Peter, Okano, Teruo, Oliveira, Jose, Park, Tai Hyun, Penner, Reginald M, Prato, Maurizio, Puntes, Victor, Rotello, Vincent M, Samarakoon, Amila, Schaak, Raymond E, Shen, Youqing, Sjöqvist, Sebastian, Skirtach, Andre G, Soliman, Mahmoud G, Stevens, Molly M, Sung, Hsing-Wen, Tang, Ben Zhong, Tietze, Rainer, Udugama, Buddhisha N, VanEpps, J Scott, Weil, Tanja, Weiss, Paul S, Willner, Itamar, Wu, Yuzhou, Yang, Lily, Yue, Zhao, Zhang, Qian, Zhang, Qiang, Zhang, Xian-En, Zhao, Yuliang, Zhou, Xin, and Parak, Wolfgang J

Subjects
Animals, Humans, Neoplasms, Drug Carriers, Drug Delivery Systems, Particle Size, Nanotechnology, Nanomedicine, Nanoparticles, Bioengineering, Prevention, Biotechnology, 5.1 Pharmaceuticals, Generic Health Relevance, Nanoscience & Nanotechnology
Abstract

The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

Published
2017

7. Nanoscience and Nanotechnology Cross Borders.

Author

Khademhosseini, Ali, Chan, Warren WC, Chhowalla, Manish, Glotzer, Sharon C, Gogotsi, Yury, Hafner, Jason H, Hammond, Paula T, Hersam, Mark C, Javey, Ali, Kagan, Cherie R, Kotov, Nicholas A, Lee, Shuit-Tong, Li, Yan, Möhwald, Helmuth, Mulvaney, Paul A, Nel, Andre E, Parak, Wolfgang J, Penner, Reginald M, Rogach, Andrey L, Schaak, Raymond E, Stevens, Molly M, Wee, Andrew TS, Brinker, Jeffrey, Chen, Xiaoyuan, Chi, Lifeng, Crommie, Michael, Dekker, Cees, Farokhzad, Omid, Gerber, Christoph, Ginger, David S, Irvine, Darrell J, Kiessling, Laura L, Kostarelos, Kostas, Landes, Christy, Lee, Takhee, Leggett, Graham J, Liang, Xing-Jie, Liz-Marzán, Luis, Millstone, Jill, Odom, Teri W, Ozcan, Aydogan, Prato, Maurizio, Rao, CNR, Sailor, Michael J, Weiss, Emily, and Weiss, Paul S

Subjects
Nanoscience & Nanotechnology
Published
2017

8. Nanoscience and Nanotechnology Impacting Diverse Fields of Science, Engineering, and Medicine.

Author

Chan, Warren WC, Chhowalla, Manish, Glotzer, Sharon, Gogotsi, Yury, Hafner, Jason H, Hammond, Paula T, Hersam, Mark C, Javey, Ali, Kagan, Cherie R, Khademhosseini, Ali, Kotov, Nicholas A, Lee, Shuit-Tong, Li, Yan, Möhwald, Helmuth, Mulvaney, Paul A, Nel, Andre E, Nordlander, Peter J, Parak, Wolfgang J, Penner, Reginald M, Rogach, Andrey L, Schaak, Raymond E, Stevens, Molly M, Wee, Andrew TS, Willson, C Grant, Fernandez, Laura E, and Weiss, Paul S

Subjects
Nanoscience & Nanotechnology
Published
2016

9. Nano Day: Celebrating the Next Decade of Nanoscience and Nanotechnology.

Author

Kagan, Cherie R, Fernandez, Laura E, Gogotsi, Yury, Hammond, Paula T, Hersam, Mark C, Nel, André E, Penner, Reginald M, Willson, C Grant, and Weiss, Paul S

Subjects
Nanotechnology, Bioengineering, Nanoscience & Nanotechnology
Abstract

Nanoscience and nanotechnology are poised to contribute to a wide range of fields, from health and medicine to electronics, energy, security, and more. These contributions come both directly in the form of new materials, interfaces, tools, and even properties as well as indirectly by connecting fields together. We celebrate how far we have come, and here, we look at what is to come over the next decade that will leverage the strong and growing base that we have built in nanoscience and nanotechnology.

Published
2016

10. Grand Plans for Nano

Author

Chan, Warren WC, Glotzer, Sharon, Gogotsi, Yury, Hafner, Jason H, Hammond, Paula T, Hersam, Mark C, Javey, Ali, Kagan, Cherie R, Khademhosseini, Ali, Kotov, Nicholas A, Lee, Shuit-Tong, Möhwald, Helmuth, Mulvaney, Paul A, Nel, Andre E, Nordlander, Peter J, Parak, Wolfgang J, Penner, Reginald M, Rogach, Andrey L, Schaak, Raymond E, Stevens, Molly M, Wee, Andrew TS, Willson, C Grant, Tierney, Heather L, and Weiss, Paul S

Subjects
Nanoscience & Nanotechnology
Published
2015

11. A Year for Nanoscience

Author

Chan, Warren CW, Gogotsi, Yury, Hafner, Jason H, Hammond, Paula T, Hersam, Mark C, Javey, Ali, Kagan, Cherie R, Khademhosseini, Ali, Kotov, Nicholas A, Lee, Shuit-Tong, Möhwald, Helmuth, Mulvaney, Paul A, Nel, Andre E, Nordlander, Peter J, Parak, Wolfgang J, Penner, Reginald M, Rogach, Andrey L, Schaak, Raymond E, Stevens, Molly M, Wee, Andrew TS, Willson, C Grant, and Weiss, Paul S

Subjects
Nanotechnology, Periodicals as Topic, Science, Nanoscience & Nanotechnology
Published
2014

12. Be critical but fair.

Author

Parak, Wolfgang J, Chan, Warren CW, Hafner, Jason H, Hammond, Paula T, Hersam, Mark C, Javey, Ali, Khademhosseini, Ali, Kotov, Nicholas A, Mulvaney, Paul, Nel, Andre E, Nordlander, Peter J, Penner, Reginald M, Rogach, Andrey L, Schaak, Raymond E, Stevens, Molly M, Wee, Andrew TS, Willson, C Grant, and Weiss, Paul S

Subjects
Nanoscience & Nanotechnology
Published
2013

13. Virus-PEDOT Nanowires for Biosensing

Author

Arter, Jessica A, Taggart, David K, McIntire, Theresa M, Penner, Reginald M, and Weiss, Gregory A

Subjects
Bacteriophage M13, Biosensing Techniques, Bridged Bicyclo Compounds, Heterocyclic, Microscopy, Atomic Force, Microscopy, Electron, Scanning, Nanowires, Polymers, Spectroscopy, Fourier Transform Infrared, Nanoscience & Nanotechnology
Abstract

The separate fields of conducting polymer-based electrochemical sensors and virus-based molecular recognition offer numerous advantages for biosensing. Grafting M13 bacteriophage into an array of poly (3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and viruses. The virus incorporation into the polymeric backbone of PEDOT occurs during electropolymerization via lithographically patterned nanowire electrodeposition. The resultant arrays of virus-PEDOT nanowires enable real-time, reagent-free electrochemical biosensing of analytes in physiologically relevant buffers.

Published
2010

14. Nanoscience and Nanotechnology Cross Borders

Author

Yury Gogotsi, Jeffrey Brinker, Takhee Lee, Manishkumar Chhowalla, C. N.R. Rao, Darrell J. Irvine, Wolfgang J. Parak, Ali Khademhosseini, Paula T. Hammond, Xing-Jie Liang, Emily A. Weiss, Warren W.C. Chan, Jill E. Millstone, Andre E. Nel, Molly M. Stevens, Christoph Gerber, Andrey L. Rogach, Graham J. Leggett, Yan Li, David S. Ginger, Maurizio Prato, Kostas Kostarelos, Cherie R. Kagan, Raymond E. Schaak, Andrew T. S. Wee, Sharon C. Glotzer, Luis M. Liz-Marzán, Nicholas A. Kotov, Laura L. Kiessling, Paul S. Weiss, Teri W. Odom, Reginald M. Penner, Michael F. Crommie, Xiaoyuan Chen, Omid C. Farokhzad, Christy Landes, Paul Mulvaney, Cees Dekker, Ali Javey, Michael J. Sailor, Shuit-Tong Lee, Mark C. Hersam, Lifeng Chi, Helmuth Möhwald, Aydogan Ozcan, Jason H. Hafner, Khademhosseini, Ali, Chan, Warren W. C., Chhowalla, Manish, Glotzer, Sharon C., Gogotsi, Yury, Hafner, Jason H., Hammond, Paula T., Hersam, Mark C., Javey, Ali, Kagan, Cherie R., Kotov, Nicholas A., Lee, Shuit Tong, Li, Yan, Möhwald, Helmuth, Mulvaney, Paul A., Nel, Andre E., Parak, Wolfgang J., Penner, Reginald M., Rogach, Andrey L., Schaak, Raymond E., Stevens, Molly M., Wee, Andrew T. S., Brinker, Jeffrey, Chen, Xiaoyuan, Chi, Lifeng, Crommie, Michael, Dekker, Cee, Farokhzad, Omid, Gerber, Christoph, Ginger, David S., Irvine, Darrell J., Kiessling, Laura L., Kostarelos, Kosta, Landes, Christy, Lee, Takhee, Leggett, Graham J., Liang, Xing Jie, Liz Marzán, Lui, Millstone, Jill, Odom, Teri W., Ozcan, Aydogan, Prato, Maurizio, Rao, C. N. R., Sailor, Michael J., Weiss, Emily, and Weiss, Paul S.

Subjects
Materials science, Andrey, Materials Science (all), Engineering (all), Physics and Astronomy (all), General Engineering, General Physics and Astronomy, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, General Materials Science, Nanoscience & Nanotechnology, 0210 nano-technology
Abstract

The recent ExecutiveOrder by President Trump attempting to ban temporarily the citizens of seven countries (Iran, Iraq, Libya, Somalia, Sudan, Syria, and Yemen) from entering the United States is having significant consequences within the country and around the world. The Order poses a threat to the health and vitality of science, barring students and scientists from these countries from traveling to the United States to study or to attend conferences. In preventing those members of the international scientific community from traveling beyond U.S. borders without guaranteed safe return, the Executive Order demeans them; in so doing, it demeans us all. Universities and research communities are especially impacted, as major universities have students and often faculty holding passports from one of these seven countries. This temporary ban would affect refugees fleeing war-torn areas, challenging the long-standing notion that the United States is a safe haven for those fleeing persecution and war in addition to being a magnet for talent from every corner of the world. The pages of this journal reflect the geographic, ethnic, and cultural diversity that underpins great science. The ban impacts domestic and global scientific efforts and communities. Science succeeds through the cooperation between collections of individuals and teams around the world discovering and learning from each other. To ensure rapid scientific progress, open communication and exchange between scientists are essential. As scientists, engineers, and clinicians, we have benefited from open interactions and collaborations with visitors and students from all parts of the world as well as through scientific publications and discussions at scientific meetings.

Published
2017

15. The 15th Anniversary of the U.S. National Nanotechnology Initiative

Author

Mark C. Hersam, Yury Gogotsi, Tanja Weil, Manish Chhowalla, Shuit-Tong Lee, Jill E. Millstone, Kazunori Kataoka, Andrew T. S. Wee, Ali Khademhosseini, Ali Javey, Nicholas A. Kotov, Andrey L. Rogach, Paul Mulvaney, Omid C. Farokhzad, C. Grant Willson, Molly M. Stevens, Reginald M. Penner, Cherie R. Kagan, Peter Nordlander, Sharon C. Glotzer, Yan Li, Paul S. Weiss, Warren C. W. Chan, A. K. Sood, Raymond E. Schaak, Andre E. Nel, Wolfgang J. Parak, Paula T. Hammond, Young Hee Lee, Chan, Warren CW, Chhowalla, Manish, Farokhzad, Omid, Glotzer, Sharon, Gogotsi, Yury, Hammond, Paula T, Hersam, Mark C, Javey, Ali, Kagan, Cherie R, Kataoka, Kazunori, Khademhosseini, Ali, Kotov, Nicholas A, Lee, Shuit-Tong, Lee, Young Hee, Li, Yan, Millstone, Jill E, Mulvaney, Paul, Nel, Andre E, Nordlander, Peter J, Parak, Wolfgang J, Penner, Reginald M, Rogach, Andrey L, Schaak, Raymond E, Sood, Ajay K, Stevens, Molly M, Wee, Andrew TS, Weil, Tanja, Grant Willson, C, and Weiss, Paul S

Subjects
Materials science, National Nanotechnology Initiative, General Engineering, General Physics and Astronomy, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, MD Multidisciplinary, General Materials Science, Nanoscience & Nanotechnology, 0210 nano-technology, Humanities
Abstract

Author(s): Chan, WCW; Chhowalla, M; Farokhzad, O; Glotzer, S; Gogotsi, Y; Hammond, PT; Hersam, MC; Javey, A; Kagan, CR; Kataoka, K; Khademhosseini, A; Kotov, NA; Lee, ST; Lee, YH; Li, Y; Millstone, JE; Mulvaney, P; Nel, AE; Nordlander, PJ; Parak, WJ; Penner, RM; Rogach, AL; Schaak, RE; Sood, AK; Stevens, MM; Wee, ATS; Weil, T; Grant Willson, C; Weiss, PS

Published
2018

16. Diverse applications of nanomedicine

Author

Philipp Jungebluth, Ali Khademhosseini, Xian-En Zhang, Yuzhou Wu, Tai Hyun Park, Christian Dullin, Helmuth Möhwald, Neus Feliu, Mahmoud Soliman, Michael D. George, Nicholas A. Kotov, Buddhisha Udugama, Paul Mulvaney, Ramon A. Alvarez-Puebla, Warren C. W. Chan, Kazunori Kataoka, Sumaira Ashraf, Beatriz Pelaz, Xingyu Jiang, Yury Gogotsi, Naomi J. Halas, Yuliang Zhao, Arnold Grünweller, Laura Ballerini, Jose Oliveira, Ben Zhong Tang, Sebastian Sjöqvist, Susanna Bosi, Andre G. Skirtach, Anne M. Andrews, Teruo Okano, Daxiang Cui, Shuming Nie, Maurizio Prato, Qian Zhang, Patrick Hunziker, Alberto Escudero, Xin Zhou, Qiang Zhang, Huan Meng, Claus-Michael Lehr, Christoph Alexiou, Youqing Shen, Wolfgang J. Parak, Luis M. Liz-Marzán, Lajos P. Balogh, Ji Jian, Andre E. Nel, Molly M. Stevens, Xiaowei Ma, Paul S. Weiss, Zhao Yue, Rainer Tietze, Xiaodong Chen, Raymond E. Schaak, Zhongwei Gu, Chunying Chen, Hsing-Wen Sung, Jindřich Kopeček, Xing-Jie Liang, Alessandra Bestetti, Lily Yang, Harald F. Krug, Paolo Macchiarini, Mei Ling Lim, Vincent M. Rotello, Mónica Carril, Tanja Weil, Zhen Cheng, Pranav Kadhiresan, J. Scott VanEpps, Roland K. Hartmann, Mark C. Hersam, Xiaoyuan Chen, Itamar Willner, Mingyuan Gao, Dong Soo Lee, Amila Samarakoon, Peter Nordlander, Norbert Hampp, Víctor F. Puntes, Cornelia Brendel, Reginald M. Penner, Kam W. Leong, Jianzhong Du, Frauke Alves, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS),Saarland 9 University, 66123 Saarbrücken, Germany., Pelaz, Beatriz, Alexiou, Christoph, Alvarez Puebla, Ramon A., Alves, Frauke, Andrews, Anne M., Ashraf, Sumaira, Balogh, Lajos P., Ballerini, Laura, Bestetti, Alessandra, Brendel, Cornelia, Bosi, Susanna, Carril, Monica, Chan, Warren C. W., Chen, Chunying, Chen, Xiaodong, Chen, Xiaoyuan, Cheng, Zhen, Cui, Daxiang, Du, Jianzhong, Dullin, Christian, Escudero, Alberto, Feliu, Neu, Gao, Mingyuan, George, Michael, Gogotsi, Yury, Grünweller, Arnold, Gu, Zhongwei, Halas, Naomi J., Hampp, Norbert, Hartmann, Roland K., Hersam, Mark C., Hunziker, Patrick, Jian, Ji, Jiang, Xingyu, Jungebluth, Philipp, Kadhiresan, Pranav, Kataoka, Kazunori, Khademhosseini, Ali, Kopeček, Jindřich, Kotov, Nicholas A., Krug, Harald F., Lee, Dong Soo, Lehr, Claus Michael, Leong, Kam W., Liang, Xing Jie, Ling Lim, Mei, Liz Marzán, Luis M., Ma, Xiaowei, Macchiarini, Paolo, Meng, Huan, Möhwald, Helmuth, Mulvaney, Paul, Nel, Andre E., Nie, Shuming, Nordlander, Peter, Okano, Teruo, Oliveira, Jose, Park, Tai Hyun, Penner, Reginald M., Prato, Maurizio, Puntes, Victor, Rotello, Vincent M., Samarakoon, Amila, Schaak, Raymond E., Shen, Youqing, Sjöqvist, Sebastian, Skirtach, Andre G., Soliman, Mahmoud G., Stevens, Molly M., Sung, Hsing Wen, Tang, Ben Zhong, Tietze, Rainer, Udugama, Buddhisha N., Vanepps, J. Scott, Weil, Tanja, Weiss, Paul S., Willner, Itamar, Wu, Yuzhou, Yang, Lily, Yue, Zhao, Zhang, Qian, Zhang, Qiang, Zhang, Xian En, Zhao, Yuliang, Zhou, Xin, Parak, Wolfgang J., German Academic Exchange Service, Chinese Academy of Sciences, National Natural Science Foundation of China, National Basic Research Program (China), European Commission, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Swiss National Science Foundation, Julian Schwinger Foundation, Claude Leon Foundation, National Science Foundation (US), Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Alexander von Humboldt Foundation, Lars Hierta Memorial Foundation, Eusko Jaurlaritza, Research Grants Council (Hong Kong), National Cancer Institute (US), Junta de Andalucía, Research Foundation - Flanders, and German Research Foundation

Subjects
Technology, Chemistry, Multidisciplinary, neurons, General Physics and Astronomy, 02 engineering and technology, Settore BIO/09 - Fisiologia, 01 natural sciences, Engineering (all), Drug Delivery Systems, Imaging tools, Neoplasms, Medicine and Health Sciences, Nanotechnology, General Materials Science, Diverse applications, nanomaterials, Wearable technology, Drug Carriers, Chemistry, Physical, General Engineering, 021001 nanoscience & nanotechnology, Wearable devices, 3. Good health, Chemistry, Nanomedicine, Physical Sciences, QUANTUM-DOT BARCODES, Science & Technology - Other Topics, Medicine, Materials Science (all), 0210 nano-technology, Nano Focus, Materials science, Materials Science, Physics and Astronomy (all), Materials Science, Multidisciplinary, 010402 general chemistry, MESENCHYMAL STEM-CELLS, Vaccine development, TARGETED DRUG-DELIVERY, LABEL-FREE DETECTION, MESOPOROUS SILICA NANOPARTICLES, High throughput screening, MD Multidisciplinary, Animals, Humans, SURFACE-PLASMON RESONANCE, Nanoscience & Nanotechnology, Particle Size, cell physiology, FIELD-EFFECT TRANSISTOR, Biomedicine, Science & Technology, carbon nanotubes, business.industry, COATED GOLD NANOPARTICLES, neurology, IRON-OXIDE NANOPARTICLES, Biology and Life Sciences, Data science, nanomedicine, neurology, nanomaterials, carbon nanotubes, cell physiology, neurons, 0104 chemical sciences, Physics and Astronomy, Targeted drug delivery, Nanoscale size, Nanoparticles, ENHANCED RAMAN-SCATTERING, Drug Delivery, business
Abstract

The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic., This work was supported by the Deutscher Akademischer Austauschdienst (DAAD to Philipps Universität Marburg and Zhejiang University, Hangzhou), the Chinesisch Deutsches Zentrum für Wissenschaftsförderung (“CDZ” to Z.G. and W.J.P.), and the Chinese Academy of Science (CAS). Part of this work was supported by the National Natural Science Foundation (51390481, 81227902, 81625011), National Basic Research Program (2014CB931900) of China (to Y.S.), by the European Commission grant Futurenanoneeds (to V.P. and W.J.P.), by the Spanish Ministerio de Economia y Competitividad (CTQ2011-23167 and CTQ2014-59808R to R.A.A.P.), the Generalitat of Catalunya (2014-SGR-612 to R.A.A.P.), the Deutsche Forschungsgemeinschaft (DFG) (AL552/8-1 to R.T.), the Swiss National Science Foundation (NRP62 to P.H.), the Claude & Julianna Foundation (grant to P.H.), the National Science Foundation (NSF) grants CHE-1306928 (to R.P.) and ECS-0601345; CBET 0933384; CBET 0932823; and CBET 1036672 (to N.A.K.), Canadian Institute of Health Research (grant to W.C.W.C.), and Natural Sciences and Engineering Research Council of Canada (grant to W.C.W.C.). S.A. and B.P. acknowledge a fellowship from the Alexander von Humboldt Foundation. N.F. acknowledges the Lars Hiertas Minne Foundation. M.C. acknowledges Ikerbasque for a Research Fellow position. X.C. acknowledges the Intramural Research Program (IRP), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH). B.Z.T. acknowledges the Innovation and Technology Commission of Hong Kong (ITC-CNERC14SC01). The Pancreatic Cancer research of A.E.N. and H.M. was funded by the U.S. National Cancer Institute, NIH grant # U01CA198846. A.E. acknowledges Junta de Andalucía (Spain) for a Talentia Postdoc Fellowship, co-financed by the European Union's Seventh Framework Programme, grant agreement no 267226. A.G.S. acknowledges support by BOF (UGent) and FWO (Research Foundation Flanders). Part of this work was supported by the National Natural Science Foundation of China.

Published
2017

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