1. Probing Interactions between Chiral Plasmonic Nanoparticles and Biomolecules.
- Author
-
Tadgell B and Liz-Marzán LM
- Subjects
- Circular Dichroism, Stereoisomerism, Surface Plasmon Resonance methods, Nanoparticles chemistry
- Abstract
Chiral plasmonic nanoparticles (and their assemblies) interact with biomolecules in a variety of different ways, resulting in distinct optical signatures when probed by circular dichroism spectroscopy. These systems show promise for biosensing applications and offer several advantages over achiral plasmonic systems. Arguably the most notable advantage is that chiral nanoparticles can differentiate between molecular enantiomers and can, therefore, act as sensors for enantiomeric purity. Furthermore, chiral nanoparticles can couple more effectively to chiral biomolecules in biological systems if they have a matching handedness, improving their effectiveness as biomedical agents. In this article, we review the different types of interactions that occur between chiral plasmonic nanoparticle systems and biomolecules, and discuss how circular dichroism spectroscopy can probe these interactions and inform how to optimize systems for biosensing and biomedical applications., (© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)
- Published
- 2023
- Full Text
- View/download PDF