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Silver nanoparticles have attracted great attention in the biomedical research field, especially in cancer theranostics. In this study, we developed a synthesis method for silver nanoparticles in the solid state using high-speed vibration milling, in which biocompatible polymers such as poly(vinylpyrrolidone), poly(ethylene glycol) and chitosan were used for the reduction of the silver salt. The synthesis of the size-tunable silver nanoparticles was performed at room temperature and no surfactants to direct the anisotropic growth of the nanoparticles were required. The formation of the nanoparticles was studied using UV-visible and Fourier transform infrared spectroscopy as well as transmission electron microscopy. The synthesized nanoparticles showed an average diameter ranging from 3.1 ± 1.4 to 22.8 ± 5.8 nm. In addition, the anticancer activity of these silver nanoparticles was assessed using cytotoxicity studies with human breast adenocarcinoma (MCF-7), human lung adenocarcinoma (NCI-H358) and mouse embryonic fibroblast (NIH-3T3) cell lines. Accordingly, an effective suppression of the proliferation of cell growth was found. © 2016 Society of Chemical Industry

Silver nanoparticles have been used for a long time and recently various methods have been additionally developed for their production. Here we report for the first time a solid-state highspeed vibration milling method for the synthesis of silver nanoparticles, in which poly-(vinylpyrrolidone) is used for the reduction of the silver salt. The synthesis is performed at room temperature and no surfactant to direct the anisotropic growth of the nanoparticles is required. The formation of the nanoparticles was studied by UV―Visible spectroscopy, transmission electron microscopy, and powder X-ray diffraction techniques. The nanoparticles synthesized were found to be uniform in size and shape with an average diameter of less than 5 nm. In addition, the antimicrobial activity of these silver nanoparticles was investigated against Escherichia coli and found to be positive.

Gold nanoparticles have attracted considerable interest due to their salient properties and many methods for their fabrication have been developed. In this study, for the first time a solid state method for their synthesis has been designed and developed. Thus, high-speed vibration milling has been used for the synthesis of gold nanoparticles, where sodium borohydride was used for the reduction of the gold salt. Poly(vinylpyrrolidone) was used as a protecting agent for the gold nanoparticles synthesized. This system used for the synthesis of the gold nanoparticles required only room temperature and yielded mostly polyhedral nanoparticles with diameters ranging from 6.3 ± 2.1 to 27.9 ± 6.2 nm. The size of the nanoparticles was tunable by varying different reaction parameters such as the molar mass of polymer protecting agent, reaction time, and the mass ratio of gold precursor and polymer protecting agent. The nanoparticles were characterized by UV-visible spectroscopy, Fourier transform-infrared spectroscopy, transmission electron microscopy, and powder X-ray diffraction techniques.