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The research and development for biomedical applications are recently focused on multifunctional nanoparticles. To integrate various functionalities, different methods of modifying the particle’s physical properties are developed. Among the considered, nanodiamond (ND) is a promising candidate for the development of multifunctional complex due to its variable features in size, structure, surface chemistry, physical properties, and biocompatibility. In addition to its well-studied structural, surface, electrochemical and photonic properties, strong magnetism of ND can be observed. In the present work, magnetically modified ND is introduced in terms of its bioapplications. Along with the soft ferromagnetism of ND, the increased fluorescence at one- and two-photon excitation is realized. Utilizing the combined magnetic and fluorescence properties of the magnetically modified ND, fluorescence imaging, fluorescence lifetime imaging and manipulation of cells by magnetic field are demonstrated. The perspectives to use the magnetic ND for drug delivery, cells magnetic separation and filtration, in bioengineering to control the cell distribution combined with imaging and treatment are discussed.

This errata corrects an error in “Multifunctional biomedical applications of magnetic nanodiamond.”

Nanodiamond powder, first discovered in 1963 in the Soviet Union, has recently become one of the most promising and well-studied nanomaterials applied in various fields of science, technology and medicine. However, in spite of the unique properties of nanodiamonds, developed applications and the scaled manufacturing process, the nanodiamond global market still remains in its initial stage. The main factor limiting the extensive use of nanodiamonds in industry is the lack of consistency with regards to quality and there is wide variability in their performance in diverse technological processes. This is caused mainly by the uncontrolled character of the existing technology for nanodiamond fabrication, which is based on detonation in a closed chamber. Therefore, the development of alternative technologies, enabling control of the synthesis process, is important as it can provide high quality nanodiamonds for electronics, optics, energy and pharmacology. This chapter reports on a controlled green technology for the synthesis of nanodiamonds by the treatment of specially prepared hydrocarbon targets. Characterization of the nanodiamonds is performed by modern technology and some of the technological opportunities are discussed with regards to nanodiamond applications.

Nanodiamond powder (ND) has become one of the most promising and well-studied nanomaterials applied in various fields of science, technology and medicine. Recent achievements in the development of advanced ND applications present new demands to ND quality: purity, homogeneity of primary particle dimensions and surface area chemistry. ND produced by state-of-the-art technology of detonation synthesis doesn’t meet requirements for biomedical and optical applications. Therefore, alternative methods of ND synthesis from pure carbon raw materials enabling to control the process are of especial importance.The novel technology for ND laser synthesis has been developed by Ray Techniques Ltd. The method is based on high-intensive laser radiation treatment of the specially prepared target containing non-diamond carbon soot and hydrocarbons, placed in a liquid media. As a result, carbon atoms collect to form a cubic diamond crystalline lattice. To reach that, the appropriate parameters of the laser radiation, special composition of the target and the liquid media, as well as the treatment procedures were determined. The “winning” combination of these factors enables to obtain pure nanodiamonds (RayND). In contrast to the existing technology, the RT method is highly controllable, environment-friendly and efficient.RayND obtained under different conditions were studied and compared with detonation ND currently available at the market. It is proved that the higher level of purity and homogeneity of RayND constitutes significant advantages for most ND applications. Using RayND opens new frontiers in biomedicine (drug- and gene-delivery and bio-imaging agents), electronic industry (abrasives for wafer polishing, heat-conductive electrical-insulating compounds, CVD coatings, emitters, etc) and optics (displays, protective transparent films, laser lenses, optical windows and filters).

The toxicity of nanomaterials raises major concerns because of the impact that nanomaterials may have on health, which remains poorly understood. We need to explore the fate of individual nanoparticles in cells at nano and molecular levels to establish their safety. Conformational changes in secondary protein structures are one of the main indicators of impaired biological function, and hence, the ability to identify these changes at a nanoscale level offers unique insights into the nanotoxicity of materials. Here, we used nanoscale infrared spectroscopy and demonstrated for the first time that nanodiamond-induced alterations in both extra- and intracellular secondary protein structures lead to the formation of antiparallel β-sheet, β-turns, intermolecular β-sheet, and aggregation of proteins. These conformational changes of the protein structure may result in the loss of functionality of proteins and in turn lead to adverse effects.