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Lung cancer (LC) is the most-deadly type of cancer representing a major public health problem worldwide. Tuberculosis TB is another infectious disease influencing lungs that causes death especially in developing countries. The present study is the first to report antimycobacterial activity of TMC/Ag nanocomposite. It aims to solve the case of lung cancer and its most associative pathogen. The current study reports one pot green biosynthesis of silver nanocomposite in presence of biodegradable biopolymer (N,N,N-trimethyl chitosan chloride, TMC) as both reducing and stabilizing agent. The structure of TMC/Ag nanocomposite was characterized with different analysis tools including TEM, XRD and UV-vis spectrophotometer techniques. TEM images showed that Ag nanoparticles were well distributed spheres and their diameter ranged from 11 to17.5 nm. While, XRD pattern of TMC/Ag nanocomposite showed diffraction peaks related to the crystalline nature of Ag nanoparticles. In addition, UV-vis spectrum revealed a broad absorption peak at 400 nm attributing to the surface Plasmon resonance (SPR) of Ag. TMC/Ag nanocomposite exhibited a promising in vitro antimycobacterial activity with MIC of 1.95 μg/mL. On the other hand, The antitumor activity results of nanocomposites against both lung carcinoma cells (A-549) and normal lung cells (WI 38) revealed that nanocomposite cytotoxicity against A-549 cells with IC 50 of 12.3 μg/mL, whereas the IC 50 value against normal WI 38 cells was 357.2 μg/mL., (Copyright © 2019 Elsevier B.V. All rights reserved.)