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Due to the obvious minimal doses of drugs in biological matrices as well as the societal difficulties caused by methamphetamine usage, methamphetamine identification is critical in clinical and forensic laboratories. Because of their simple and inexpensive production procedure, as well as their excellent selectivity and sensitivity, polymeric carbon-based nanocomposites are strong contenders for the diffusive solid-phase extraction approach. The diffusive solid-phase extraction absorbent nanographene oxide polypyrrole composite was produced and used to recover methamphetamine from a complicated urine substrate. The generated NGPPC was fully characterized, and the significant extracting parameters have been explored using the one-parameter-at-a-time strategy. NGOPC is being used to extract methamphetamine using a urine medium with high efficiency. The NGPPC synthesizing procedure was easy, and the extraction method will demonstrate good repeatability. Moreover, the practical and efficient synthesis process stimulates the use of carbon-based compounds in various extraction procedures. As for detecting and quantifying equipment, HPLC monitors are being used. 300 mL methanol, 7 min extracting and desorption duration, 5000 mixing frequency, urinary pH value of 20, 40 mg adsorption, and 5 mL amount of urine were the optimal extraction variables. Following tracing the calibration graph, the method's linear ranges were determined to be 40-600 ng/ml. The detection limits (LOD) and quantitation limits (LOQ), correspondingly, were 10 and 35.80 ng/mL. The proposed methodology seemed to have a detection range of 9 ng/mL. The suggested approach's applicability in numerous characterization and medical facilities was proven by the examination of addicted subjects using the proposed technique. For successful extraction of methamphetamine using biological urine samples, the carbon-based adsorbent was being used as diffusive solid-phase extraction adsorption. [ABSTRACT FROM AUTHOR]

Nanocomposites are preferred for performance enhancement over micron composites because of their better performance in enhancing the desired properties of the parent material. Nano-silicon carbide and nano-graphite are considered together for reinforcement of Al7075 in this piece of research. Here, the purpose of reinforcement of graphite considered is to improve machinability. The stir casting was employed for fabrication of nanocomposite. The composite matrix includes Al7075 matrix material, reinforcement material of nano-SiC (5 wt.%), and nano-graphite (5 wt.%). Wire cut Electrical Discharge Machining (WEDM) of the synthesized nanocomposite SiC/Gr/Al7075 is considered for investigating the machinability. The objectives of the study are to synthesize the novel nanocomposite and optimize the process parameters to minimize the kerf width during WEDM. The independent variables like choice of wire electrode including the uncoated brass wire, diffused annealed wire, and zinc coated brass wire were considered along with operating parameters like gap voltage, pulse-off time (Toff), and pulse-on time (Ton). The response surface methodology (RSM) is used for designing experiments and analyzing and optimizing independent parameters of WEDM for minimizing the kerf width. Experimental results reveal that the machinability performance of the novel nanocomposite in WEDM with zinc coated brass wire was the best and produced minimum kerf width with the optimized inputs of 117 μs pulse-on time, 60 μs pulse-off time, 160A input current, and 10 volt gap voltage. [ABSTRACT FROM AUTHOR]

In the present investigation an attempt was made to synthesize nano-SiC/BN-reinforced Al–Zn–Mg alloy composites by varying its weight percentage of SiC (2wt%, 4wt%, 6wt%) and maintaining 3wt% BN using the squeeze casting method and comparing it with as-cast aluminium alloy. SEM and ASTM standards are used to examine the morphology and mechanical behaviour of the synthesized aluminium alloy hybrid nanocomposite. Morphological study reveals that synthesized nanocomposites show uniform distribution of reinforcement particles without indication of residual pores. Due to the presence of Mg2Si interfaces and reduction in shrinkage effects during solidification, the density and porosity of hybrid intermixtures are increased to a minimum of 0.08% and reduced to 0.0026%. In comparison with as-cast Al–Zn–Mg alloy the hardness (28.37%), tensile strength (32.53), and yield strength (34.13%), flexural (31.25%), and impact strength (27.27%) significantly improved due to enhanced wettability between the intermixture and improved grain refinement. By increasing the proportion of strengthening particles, it was found that reducible dislocation motion was observed, resulting in an improved wear rate (26.82%) of the synthesized intermixture. [ABSTRACT FROM AUTHOR]