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2 results on '"Sengelen M"'

1. Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits.

Author

Sepici-Dincel A, Açikgöz S, Cevik C, Sengelen M, and Yeşilada E

Subjects
Alloxan, Animals, Antioxidants isolation & purification, Catalase drug effects, Catalase metabolism, Female, Glucose metabolism, Homeostasis drug effects, Hypoglycemic Agents isolation & purification, Lipid Peroxidation drug effects, Liver drug effects, Liver metabolism, Male, Malondialdehyde metabolism, Nitrates metabolism, Nitrites metabolism, Oxidative Stress drug effects, Plant Oils isolation & purification, Plants, Medicinal chemistry, Rabbits, Superoxide Dismutase drug effects, Superoxide Dismutase metabolism, Antioxidants pharmacology, Diabetes Mellitus, Experimental drug therapy, Hypoglycemic Agents pharmacology, Myrtus chemistry, Plant Oils pharmacology
Abstract

In this study we aimed to evaluate the in vivo effects of myrtle oil (myrtii oleum) on the antioxidant enzymes such as superoxide dismutase and catalase, the levels of malondialdehyde in liver tissues as an index of lipid peroxidation and nitrite-nitrate levels in normoglycaemic and alloxan-induced diabetic and MO-treated rabbits. In our previous study, we assumed that MO with a dose of 50 mg/kg, possesses a hypoglycemic activity and this activity was independent from the effects of insulin. Myrtle oil exerts its hypoglycemic activity by enhanced glycolysis, glycogenesis and decreased glycogenolysis. What is more glucose load data strongly suggest that MO treatment produces hypoglycemia mainly by reducing intestinal absorption of glucose, so MO could be an alpha-glycosidase enzyme inhibitor which had a hypoglycaemic effect only on alloxan-induced diabetic rabbits on the fourth hour and on orally glucose loaded group. The major finding of this new study is that, MO may not offer any protection against oxidative stress during acute studies in normoglycemic and diabetic groups. Although the levels of superoxide dismutase and catalase enzyme activities did not change during acute studies in diabetes + MO group, there was a significant change at the end of 21 days. There is a very limited knowledge about MO and its effects on diabetes. Therefore, we tried to explain the mechanism that might underlie the protective effects of MO with this paper.

Published
2007
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2. Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits

Author

Aylin Sepici-Dincel, Erdem Yesilada, Şereften Açıkgöz, Cemal Çevik, Meltem Şengelen, Sepici-Dincel, A., Açikgöz, S., Çevik, C., Sengelen, M., Yeşilada, E., Yeditepe Üniversitesi, and Zonguldak Bülent Ecevit Üniversitesi

Subjects
Male, Myrtus communis L, Volatile oil, medicine.medical_treatment, Lipid peroxidation, Pharmacology, Intestinal absorption, Antioxidants, Diabetes Mellitus, Experimental, Superoxide dismutase, chemistry.chemical_compound, Diabetes mellitus, Alloxan, Malondialdehyde, Drug Discovery, Alloxan-induced diabetic, medicine, Animals, Homeostasis, Hypoglycemic Agents, Plant Oils, Nitrites, Myrtus communis, Nitrates, Plants, Medicinal, biology, Chemistry, Superoxide Dismutase, Insulin, medicine.disease, Catalase, Myrtle oil, Myrtus, Oxidative Stress, Glucose, Biochemistry, Liver, Glycogenesis, biology.protein, Female, Antioxidant enzymes, Rabbits, Nitrite-nitrate
Abstract

In this study we aimed to evaluate the in vivo effects of myrtle oil (myrtii oleum) on the antioxidant enzymes such as superoxide dismutase and catalase, the levels of malondialdehyde in liver tissues as an index of lipid peroxidation and nitrite-nitrate levels in normoglycaemic and alloxan-induced diabetic and MO-treated rabbits. In our previous study, we assumed that MO with a dose of 50 mg/kg, possesses a hypoglycemic activity and this activity was independent from the effects of insulin. Myrtle oil exerts its hypoglycemic activity by enhanced glycolysis, glycogenesis and decreased glycogenolysis. What is more glucose load data strongly suggest that MO treatment produces hypoglycemia mainly by reducing intestinal absorption of glucose, so MO could be an alpha-glycosidase enzyme inhibitor which had a hypoglycaemic effect only on alloxan-induced diabetic rabbits on the fourth hour and on orally glucose loaded group. The major finding of this new study is that, MO may not offer any protection against oxidative stress during acute studies in normoglycemic and diabetic groups. Although the levels of superoxide dismutase and catalase enzyme activities did not change during acute studies in diabetes + MO group, there was a significant change at the end of 21 days. There is a very limited knowledge about MO and its effects on diabetes. Therefore, we tried to explain the mechanism that might underlie the protective effects of MO with this paper. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Published
2007

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