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Background: There have been a series of reports indicating that scleral buckling (SB) surgery may induce high myopia in advanced retinopathy of prematurity. The mechanism of SB on refractive change in children, however, is not clearly known. We designed this study to investigate the effects of SB on refractive error and ocular growth in young rabbits and demonstrate their mechanisms., Methods: For the study, SB surgery was performed on the right eyes of nine 5-week-old rabbits and 11 8-week old rabbits, with encircling buckle. The left eyes were monitored for control. Spherical equivalent, corneal power, and axial length were measured before SB and postoperatively at 2, 4, and 8 weeks. We compared the experimental group with the control group and analyzed the influence of age at the time of operation., Results: In the control group of eyes, corneal power decreased, axial length increased, and spherical equivalent developed emmetropization with aging. In all eyes that underwent SB surgery, high myopia developed, with the increase in axial length as a major factor in inducing myopia. These changes were greater in the 5-week-old group than in the 8-week-old group. In the eyes that underwent SB surgery, axial length increased more than the eyes in the control group up to 2 weeks after surgery, but ocular growth was arrested after that time., Conclusions: SB in young rabbits effects ocular growth and results in high myopia, and an increase of axial length plays a major role in this mechanism. Also, the difference in the effects of SB according to age at the time of surgery may suggest that SB in premature infants could induce a significant axial myopia and secondary amblyopia.

Background/aims: A longitudinal study of premature infants was conducted to examine changes in refractive status and their relation with age and factors influencing the occurrence and degree of myopia. Identification of which of the various refractive factors play important parts in relation to myopia in premature infants was attempted., Methods: Under observation were 125 eyes in 65 patients who were found to demonstrate no signs of retinopathy of prematurity (ROP) or who had grade I or II ROP without or after cryotherapy. Cycloplegic refractions were conducted at 6 months, 3 years, and 6 years of age; at 6 years of age keratometric values, lens thicknesses, and axial lengths were recorded, and anterior chamber depths also were measured., Results: Myopia begins to appear at 6 months of age and its severity increases between the ages of 6 months and 3 years. The condition showed no further progress in subjects older than 3 years. Of the 104 eyes with ROP, those eyes with cicatricial retinopathy tended towards myopia and high myopia while there was no difference in the degree of myopia related to whether or not cryotherapy was conducted. At 6 years of age, the premature infants exhibited shallower anterior chambers, thicker lenses, and higher axial lengths when the degree of the myopia was higher. The keratometric values, however, appeared to bear no relation to the degree of the myopia., Conclusion: These results suggest that the occurrence of myopia is related more strongly to whether or not there is cicatricial retinopathy than whether or not there is cryotherapy. Also, the degree of the myopia was found to be related to the depth of the anterior chamber, the thickness of the lens, and the change in axial length but not to keratometric value.

To investigate the chronological change of refraction in premature infants after cryotherapy for retinopathy of prematurity (ROP), cycloplegic refractions had been performed at 6 months and 3 years after term in premature infants who underwent cryotherapy for ROP. The changes of refractions between the two study ages were evaluated not only in the total cryo-treated eyes, but also in the subdivided groups according to the posterior pole appearances. In the total 61 eyes of 32 premature infants, mean spherical equivalents were -4.05D vs. -5.94D (6 months vs. 3 years) (p = 0.0001). In the normal posterior pole group (48 eyes), mean spherical equivalents were -3.45D vs. -5.68D (6 months vs. 3 years) (p = 0.0000), and in the abnormal posterior pole group (13 eyes), -6.28D vs. -6.86D (6 months vs. 3 years) (p = 0.6496). These results mean that there is a myopic progressive change between 6 months and 3 years after term in the cryo-treated eyes for acute ROP and it is more evident in the eyes with normal posterior pole.

The authors performed cycloplegic refractions in 180 eyes of 99 premature infants at the age of 6 months to evaluate the incidence and the degree of myopia according to the development and disease course of retinopathy of prematurity (ROP) and to investigate the effect of cryotherapy on the refractive error. The incidences of myopia were not different between premature infants without ROP and premature infants with spontaneously and totally regressed ROP (36.3%, 25.5%), and the degrees of myopia were low in both groups (-1.76 D, -2.25 D). In premature infants with totally regressed ROP after cryotherapy, the incidence of myopia was high (75.5%) but the degree of myopia was low (-3.03 D). In premature infants with cicatricial ROP, cryotreated or not, both the incidence and the degree of myopia were high (93.9%, -5.50 D). It is suggested that cryotherapy increases the incidence of myopia but the degree of myopia induced by cryotherapy is low.