1. Therapeutic effect of recombinant lentiviral vector containing succinate dehydrogenase iron-sulfur protein on the treatment of experimental autoimmunity myocarditis.
- Author
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Han L, Wang C, Guo S, Liu S, and Yang L
- Subjects
- Animals, Apoptosis, Autoimmunity, Cardiomyopathy, Dilated therapy, Disease Models, Animal, Echocardiography, Electron Transport, Genetic Therapy, Heart Failure therapy, Hemodynamics, Inflammation, Iron-Sulfur Proteins genetics, Mitochondria metabolism, Oxidative Phosphorylation, Oxidative Stress, Rats, Rats, Inbred Lew, Succinate Dehydrogenase genetics, Autoimmune Diseases therapy, Genetic Vectors, Iron-Sulfur Proteins therapeutic use, Lentivirus genetics, Myocarditis therapy, Succinate Dehydrogenase therapeutic use
- Abstract
Cardiac autoimmune reaction takes part in myocarditis, dilated cardiomyopathy and heart failure. Existing literature has confirmed that the occurrence of cardiomyopathy belongs to mitochondrial diseases and is related to the oxidative respiratory chain subunit. The special structure of iron-sulfur protein (ISP) is responsible for the oxidative stress in oxidative phosphorylation, which is also a target that is easily attacked by various damage factors. Using gene therapy technology to restore succinate dehydrogenase iron-sulfur protein (SDISP) function- and thus resume myocardial mitochondria function and myocardial function is hypothesized to alleviate the experimental autoimmunity myocarditis (EAM)., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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