1. Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration.
- Author
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Vicencio, Jose M., Archer, Caroline R., and Pointon, Amy
- Subjects
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DRUG discovery , *MEDICATION safety , *CARDIOVASCULAR agents , *DRUG side effects , *MONONUCLEAR leukocytes , *MYOCARDIAL infarction - Abstract
The article discusses the evolving field of cardiac safety in drug discovery and the need for integration with immunology. It highlights the historical evolution of cardiac safety assessments and the increasing attention given to hemodynamic and structural alterations. The article also discusses the emergence of novel models, such as in silico predictions and 3D tissue-based systems, and the importance of incorporating immune components in these models. It specifically focuses on the risk of immune-mediated myocarditis and the need for more complex human-based in vitro models. The article concludes by discussing the potential of advanced cellular models, such as organ-on-chip systems, in improving cardiac safety assessments and reducing animal testing. [Extracted from the article]
- Published
- 2024
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