18 results on '"Altay S"'
Search Results
2. Real-World Data on the Incidence of Stroke, Myocardial Infarction, and Mortality Among Nonvalvular Atrial Fibrillation Patients in Türkiye: New Oral Anticoagulants-TURKey Study.
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Ünlü S, Altay S, Gedikli Ö, Özden Ö, Canpolat U, Aşkın L, Yayla Ç, Yanık A, Çakmak HA, Sinan ÜY, Besli F, Şahin M, and Pehlivanoğlu S
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- Humans, Prospective Studies, Rivaroxaban therapeutic use, Incidence, Turkey epidemiology, Anticoagulants therapeutic use, Atrial Fibrillation complications, Atrial Fibrillation drug therapy, Atrial Fibrillation epidemiology, Stroke epidemiology, Stroke prevention & control, Stroke complications, Myocardial Infarction epidemiology, Myocardial Infarction complications
- Abstract
Background: Atrial fibrillation (AF) is strongly associated with an increased risk of ischemic events. Anticoagulation focuses on reducing the risk of embolism. Guideline recommended CHA2DS2-VASc scoring system is most widely used; however, different scoring systems do exist. Thus, we sought to assess the impact of anticoagulant treatment and different scoring systems on the development of stroke, myocardial infarction, and all-cause mortality in patients with nonvalvular AF., Methods: The present study was designed as a prospective cohort study. The enrollment of the patients was conducted between August 1, 2015, and January 1, 2016. The follow-up period was defined as the time from enrollment to the end of April 1, 2017, which also provided at least 12 months of prospective follow-up for each patient., Results: A total of 1807 patients with AF were enrolled. During the follow-up, 2.7% (48) of patients had stroke, 0.8% (14) had myocardial infarction, and 7.5% (136) died. The anticoagulation and risk factors in AF (ATRIA) score had a better accuracy for the prediction of stroke compared to other scoring systems (0.729, 95% CI, 0.708-0.750, P <.05). Patients under low-dose rivaroxaban treatment had significantly worse survival (logrank P <.001). Age, CHA2DS2-VASc score, R2CHADS2 score, ATRIA score, chronic heart failure, prior stroke, and being under low-dose rivaroxaban treatment were independent predictors of clinical endpoint (P <.001)., Conclusion: Low-dose rivaroxaban treatment was independently and strongly associated with the combined clinical endpoint. Furthermore, the ATRIA score proved to be a stronger predictor of stroke in the Turkish population.
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- 2024
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3. Long-term prognostic significance of pentraxin-3 in patients with acute myocardial infarction: 5-year prospective cohort study.
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Altay S, Çakmak HA, Kemaloğlu Öz T, Özpamuk Karadeniz F, Türer A, Erer HB, Kılıç GF, Keleş İ, Can G, and Eren M
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- Cohort Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction blood, Predictive Value of Tests, Prospective Studies, Risk Factors, Survival Analysis, Turkey, Biomarkers blood, C-Reactive Protein metabolism, Myocardial Infarction mortality, Serum Amyloid P-Component metabolism
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Objective: A predictive role of serum Pentraxin 3 (PTX3) for short-term adverse cardiovascular events including mortality in acute myocardial infarction (AMI) was reported in recent studies. The aim of the study was to investigate long-term prognostic significance of serum PTX3 in an AMI with 5-year follow-up period in this study., Methods: In this prospective study, 140 patients, who were admitted to the emergency department between January 2011 and December 2011 with acute chest pain and/or dyspnea and diagnosed with AMI and 60 healthy controls were included. PTX3 levels were measured at admission by using an ELISA method. The study group was divided into tertiles on the basis of admission PTX3 values: the high-PTX3 group (≥4.27 ng/mL), the middle-PTX3 groups (4.27-1.63 ng/mL), and the low-PTX3 group (≤1.63 ng/mL)., Results: PTX3 level was significantly more greatly increased in the AMI group than in the controls (2.27±0.81 vs. 0.86±0.50 ng/mL, p<0.001). PTX3 level was found to be significantly positively correlated with TIMI score (r=0.368, p=0.037), high sensitive C-reactive protein (hsCRP) (r=0.452, p=0.024), pro-BNP (r=0.386, p=0.029), troponin I (r=0.417, p=<0.001), and GRACE score (r=0.355, p=0.045), and negatively correlated with HDL cholesterol (r=-0.203, p=0.016) and LVEF (r=-0.345, p=0.028). In multivariate analysis, PTX3 (OR=1.12, 95% CI 1.04-1.20; p=0.001) was a significant independent predictor of long-term cardiovascular mortality, after adjusting for other risk factors., Conclusion: PTX3 is a novel biomarker that may help to identify high risk individuals with AMI, who are potentially at risk of early major adverse cardiovascular events including mortality in the long-term period.
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- 2017
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4. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio combination can predict prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
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Çiçek G, Açıkgoz SK, Bozbay M, Altay S, Uğur M, Uluganyan M, and Uyarel H
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- Adult, Aged, Area Under Curve, Female, Hospital Mortality, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Myocardial Infarction diagnosis, Predictive Value of Tests, Proportional Hazards Models, ROC Curve, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Turkey, Blood Platelets, Lymphocyte Count, Lymphocytes, Myocardial Infarction blood, Myocardial Infarction therapy, Neutrophils, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention mortality, Platelet Count
- Abstract
We assessed the effect of combination of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting in-hospital and long-term mortality in patients (n = 2518) undergoing primary percutaneous coronary intervention (pPCI). Cutoff values for NLR and PLR were calculated with receiver-operating characteristic (ROC) curves. If both PLR and NLR were above the threshold, patients were classified as "high risk." If either PLR or NLR was above the threshold individually, patients were classified as "intermediate risk." High-risk (n = 693) and intermediate-risk (n = 545) groups had higher in-hospital and long-term mortality (7.2 4% vs 0.7%, P < .001; 14.1, 9.5% vs 4.5%, P < .001, respectively). Classifying patients into intermediate-risk group (hazards ratio [HR]: 1.492, 95% confidence interval [CI]: 1.022-2.178, P = .038) and high-risk group (HR: 1.845, 95% CI: 1.313-2.594, P < .001) was an independent predictor of in-hospital and long-term mortality. The combination of PLR and NLR can be useful for the prediction of in-hospital and long-term mortality in patients undergoing pPCI., (© The Author(s) 2014.)
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- 2015
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5. The ratio of contrast volume to glomerular filtration rate predicts in-hospital and six-month mortality in patients undergoing primary angioplasty for ST-elevation myocardial infarction.
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Çiçek G, Bozbay M, Açıkgöz SK, Altay S, Uğur M, Köroğlu B, and Uyarel H
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- Adult, Age Factors, Aged, Angioplasty, Balloon, Coronary adverse effects, Angioplasty, Balloon, Coronary instrumentation, Biomarkers blood, Comorbidity, Contrast Media administration & dosage, Creatinine blood, Female, Humans, Kaplan-Meier Estimate, Kidney physiopathology, Kidney Diseases chemically induced, Kidney Diseases diagnosis, Kidney Diseases physiopathology, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction mortality, Myocardial Infarction physiopathology, Proportional Hazards Models, Prospective Studies, Risk Assessment, Risk Factors, Smoking adverse effects, Smoking mortality, Stents, Time Factors, Treatment Outcome, Angioplasty, Balloon, Coronary mortality, Contrast Media adverse effects, Coronary Angiography adverse effects, Glomerular Filtration Rate drug effects, Hospital Mortality, Kidney drug effects, Kidney Diseases mortality, Myocardial Infarction therapy
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Background: The aim of this study is to determine the impact of ratio of contrast volume to glomerular filtration rate (V/GFR) on development of contrast-induced nephropathy (CIN) and long-term mortality in patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI)., Methods: A total of 645 patients with STEMI undergoing primary PCI was prospectively enrolled. CIN was defined as an absolute increase in serum creatinine > 0.5 mg/dL or a relative increase > 25% within 48 h after PCI. The study population was divided into tertiles based on V/GFR. A high V/GFR was defined as a value in the third tertile (> 3.7)., Results: Patients in tertile 3 were older, had higher rate of smoking, diabetes mellitus and CIN, lower left ventricular ejection fraction, hemoglobin, and systolic and diastolic blood pressure compared to tertiles 1 and 2 (p < 0.05). V/GFR was found an independent predictor of in-hospital and 6-month mortality. We found 2 separate values of V/GFR for 2 different end points. While the ratio of 3.6 predicted in-hospital mortality with 78% sensitivity and 82% specificity, the ratio of 3.3 predicted 6-month mortality with 71% sensitivity and 76% specificity. Survival rate decreases as V/GFR increases both for in-hospital and during 6-month follow-up. Diabetes mellitus and multivessel disease were other predictors of in-hospital mortality., Conclusions: High V/GFR level is associated with increased in-hospital and long-term mortality in patients with STEMI undergoing primary PCI.
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- 2015
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6. The relationship between fragmentation on electrocardiography and in-hospital prognosis of patients with acute myocardial infarction.
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Yıldırım E, Karaçimen D, Ozcan KS, Osmonov D, Türkkan C, Altay S, Ceylan US, Uğur M, Bozbay M, and Erdinler I
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- Coronary Angiography, Female, Humans, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction surgery, Prognosis, Stroke Volume, Treatment Outcome, Ventricular Function, Left, Electrocardiography, Hospitalization, Myocardial Infarction diagnosis, Myocardial Infarction physiopathology
- Abstract
Background: In patients with acute ST elevation myocardial infarction (STEMI), QRS fragmentation was determined as one of the indicators of mortality and morbidity. The development of fragmented QRS (fQRS) is related to defects in the ventricular conduction system and is linked to myocardial scar and fibrosis., Material and Methods: We prospectively enrolled 355 consecutive patients hospitalized in the coronary intensive care unit of our hospital with STEMI between the years 2010 and 2012 and their electrocardiographic features and the frequency of in-hospital cardiac events were evaluated., Results: There were 217 cases in the fQRS group and 118 cases in the control group. QRS fragmentation was found to be a predictor for major cardiac events. In the fragmented QRS group, the frequency of in-hospital major cardiac events (MACE) and death were higher (MACE p<0.001; death p<0.003). In the fragmented QRS group, the cardiac enzymes (Troponin-I, CK-MB) were significantly higher than in the control group (p<0.001). In subgroup analyses, apart from the presence of fragmentation, the presence of more than 1 type of fragmentation and the number of fragmented deviations were also found to be related with MACE. A significant negative correlation was observed with the ejection fraction and, in particular, the number of fragmented deviations., Conclusions: Fragmented QRS has emerged as a practical and easily identifiable diagnostic tool for predicting in-hospital cardiac events in acute coronary syndromes. Patients who present with a fragmented QRS demonstrate increased rates of major cardiac events, death risk, and low ejection fraction. In patients with STEMI, the presence of fQRS on the ECG and number of fQRS derivations are a significant predictor of in-hospital major cardiac events.
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- 2014
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7. Predictive value of elevated neutrophil to lymphocyte ratio in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction.
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Ergelen M, Uyarel H, Altay S, Kul Ş, Ayhan E, Isık T, Kemaloğlu T, Gül M, Sönmez O, Erdoğan E, and Turfan M
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- Female, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Risk Factors, Angioplasty methods, Lymphocytes pathology, Myocardial Infarction blood, Myocardial Infarction therapy, Neutrophils pathology
- Abstract
Objectives: The neutrophil to lymphocyte ratio (NLR) has been investigated as a new predictor for cardiovascular risk. Admission NLR would be predictive of adverse outcomes after primary angioplasty for ST-segment elevation myocardial infarction (STEMI)., Methods: A total of 2410 patients with STEMI undergoing primary angioplasty were retrospectively enrolled. The study population was divided into tertiles based on the NLR values. A high NLR (n = 803) was defined as a value in the third tertile (>6.97), and a low NLR (n = 1607) was defined as a value in the lower 2 tertiles (≤6.97)., Results: High NLR group had higher incidence of inhospital and long-term cardiovascular mortality (5% vs 1.4%, P < .001; 7% vs 4.8%, P = .02, respectively). High NLR (>6.97) was found as an independent predictor of inhospital cardiovascular mortality (odds ratio: 2.8, 95% confidence interval: 1.37-5.74, P = .005)., Conclusions: High NLR level is associated with increased inhospital and long-term cardiovascular mortality in patients with STEMI undergoing primary angioplasty.
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- 2014
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8. Prognostic value of serum resistin levels in patients with acute myocardial infarction.
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Erer HB, Sayar N, Guvenc TS, Aksaray S, Yilmaz H, Altay S, Turer A, Oz TK, Karadeniz FO, Oz D, Ekmekci A, Zencirci AE, and Eren M
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- Adult, Age Factors, Aged, Female, Humans, Male, Middle Aged, Prognosis, Risk Factors, Sex Factors, Biomarkers blood, Myocardial Infarction blood, Resistin blood
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Background: Resistin is a novel adipokine that is suggested to be involved in inflammatory conditions and atherosclerosis., Aim: To investigate the prognostic importance of resistin in acute myocardial infarction (AMI) patients., Methods: Resistin levels were measured in a population of 132 patients with AMI, of whom 72 (54%) had a diagnosis of ST elevation myocardial infarction (STEMI), and 60 (46%) had non-ST elevation myocardial infarction (NSTEMI). Thirty-three consecutive subjects who were referred to elective coronary angiography due to chest pain evaluation with normal coronary angiograms served as controls. All patients were followed-up for the occurrence of major adverse cardiac events (MACE)., Results: There was a significant increase in serum resistin levels in patients with AMI compared to controls (3.71 ± 4.20 vs. 2.00 ± 1.05, p = 0.001, respectively). However, serum resistin levels were similar in patients with STEMI and NSTEMI. (4.26 ± 5.11 vs. 3.06 ± 2.64, p = 0.49, respectively). The patients with MACE had significantly higher levels of serum resistin levels compared to either the AMI or the control group (6.35 ± 5.47, p = 0.005, respectively). Logistic regression analysis revealed that resistin, left ventricular ejection fraction, and coronary artery bypass graft were independent predictors of MACE in AMI patients (OR = 1.11, 95% CI 1.01-1.22, p = 0.03 and OR = 3.84, 95% CI 1.26-11.71, p = 0.018, respectively)., Conclusions: Serum resistin level was increased in patients with AMI and constituted a risk factor for MACE in this group.
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- 2014
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9. Acute myocardial infarction associated with thinner abuse: case report and literature review.
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Velibey Y, Altay S, Terzi S, Yesilcimen K, Golcuk Y, and Gunay E
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- Adolescent, Adult, Biomarkers blood, Blood Coagulation Tests, Coronary Angiography, Creatine Kinase, MB Form blood, Electrocardiography, Fibrinolytic Agents administration & dosage, Humans, Infusions, Intravenous, Male, Middle Aged, Myocardial Infarction blood, Myocardial Infarction diagnosis, Platelet Function Tests, Predictive Value of Tests, Time Factors, Tirofiban, Treatment Outcome, Troponin I blood, Tyrosine administration & dosage, Tyrosine analogs & derivatives, Up-Regulation, Young Adult, Inhalation Exposure adverse effects, Myocardial Infarction chemically induced, Solvents adverse effects, Substance-Related Disorders complications
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- 2013
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10. Prognostic impact of red blood cell transfusion in patients undergoing primary angioplasty for ST elevation myocardial infarction.
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Ergelen M, Uyarel H, Altay S, Ayhan E, Isik T, Bacaksiz A, Kemaloğlu T, Gül M, Cicek G, Kul S, Ertas G, and Tasal A
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- Female, Follow-Up Studies, Hospital Mortality trends, Humans, Male, Middle Aged, Myocardial Infarction mortality, Myocardial Infarction physiopathology, Odds Ratio, Prognosis, Retrospective Studies, Risk Factors, Time Factors, Turkey epidemiology, Angioplasty, Balloon, Coronary methods, Electrocardiography, Erythrocyte Transfusion methods, Myocardial Infarction therapy
- Abstract
Objectives: We aimed to examine in-hospital and long-term outcomes of red blood cell (RBC) transfusions in patients undergoing a primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI)., Methods: Overall, 2537 consecutive STEMI patients (mean age 56.2 ± 11.7 years, 2111 men, 426 women) undergoing primary angioplasty were enrolled retrospectively into the present study. Patients were categorized according to whether they received RBC transfusions during hospitalization. Clinical characteristics, and in-hospital and long-term outcomes of the primary PCI were analyzed., Results: Of the consecutive 2537 patients, 88 (3.4%) received RBC transfusions during the index hospitalization. The transfused patients were older than nontransfused patients (mean age 63.6 ± 12.1 vs. 56.2 ± 11.8, P<0.001). Compared with nontransfused patients, female sex and hypertension were more prevalent in transfused patients (45.4 vs. 15.8%, P<0.001; 52.3 vs. 40.7%, P=0.04, respectively). Baseline values of hematocrit and hemoglobin were lower in patients receiving transfusion (33 ± 6.2 vs. 40.2 ± 4.7%, P<0.001; 11.1 ± 2.3 vs. 13.7 ± 1.6 mg/dl, P<0.001, respectively). The transfused patients had significantly higher in-hospital and long-term mortality (for in-hospital mortality: 10.2 vs. 2.7%, P<0.001; for long-term mortality: 14.1 vs. 5.1%, P=0.001). By multivariate Cox regression analysis, in all 2537 patients, RBC transfusion was found to be a powerful independent predictor of in-hospital cardiovascular mortality (odds ratio 8.31, P<0.001)., Conclusion: These results show that RBC transfusion is associated with increased in-hospital and long-term mortality in patients with STEMI undergoing a primary PCI.
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- 2012
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11. Patients with tombstoning pattern on the admission electrocardiography who have undergone primary percutaneous coronary intervention for anterior wall ST-elevation myocardial infarction: in-hospital and midterm clinical outcomes.
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Ayhan E, Isık T, Uyarel H, Ergelen M, Cicek G, Altay S, Eren M, and Michael Gibson C
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- Angioplasty, Balloon, Coronary, Coronary Angiography methods, Electrocardiography statistics & numerical data, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction surgery, Odds Ratio, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Factors, Stents, Survival Analysis, Treatment Outcome, Electrocardiography methods, Hospital Mortality, Myocardial Infarction mortality, Myocardial Infarction therapy, Percutaneous Coronary Intervention methods, Postoperative Complications diagnosis
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Background: A tombstoning pattern (T-pattern) is associated with in-hospital poor outcomes patients with ST-segment elevation myocardial infarction (STEMI), but no data are available for midterm follow-up. We sought to determine the prognostic value of a T-pattern on admission electrocardiography (ECG) for in-hospital and midterm mortality in patients with anterior wall STEMI treated with primary percutaneous coronary intervention (PCI)., Methods: After exclusion, 169 consecutive patients with anterior wall STEMI (mean age: 55 ± 12.9 years; 145 men) undergoing primary PCI were prospectively enrolled in this study. Patients were classified as a T-pattern (n = 32) or non-T-pattern (n = 137) based upon the admission ECG. Follow-up to 6 months was performed., Results: In-hospital mortality tended to be higher in the T-pattern group compared with non-T-pattern group (9.3% vs 2.1% respectively, P = 0.05). All-cause mortality was higher in the T-pattern group than non-T-pattern group for 6 month (P = 0.004). After adjusting the baseline characteristics, the T-pattern remained an independent predictor of 6-month all-cause mortality (odds ratio: 5.18; 95% confidence interval: 1.25-21.47, P = 0.02)., Conclusion: A T-pattern is a strong independent predictor of 6-month all-cause mortality in anterior STEMI treated with primary PCI. Therefore, it may be an indicator of high risk among patients with anterior wall STEMI., (© 2012, Wiley Periodicals, Inc.)
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- 2012
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12. Slow coronary flow in patients undergoing urgent coronary angiography for ST elevation myocardial infarction.
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Ayhan E, Uyarel H, Isık T, Ergelen M, Cicek G, Altay S, Bozbay M, and Eren M
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- Adult, Emergency Medical Services, Female, Humans, Male, Middle Aged, Myocardial Infarction epidemiology, No-Reflow Phenomenon epidemiology, Coronary Angiography methods, Myocardial Infarction diagnostic imaging, No-Reflow Phenomenon diagnostic imaging
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- 2012
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13. 'Idiopathic' acute myocardial infarction in a young patient with noncompaction cardiomyopathy.
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Güvenç TS, Erer HB, Altay S, Ilhan E, Sayar N, and Eren M
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- Cardiac Catheterization, Cardiovascular Agents therapeutic use, Coronary Angiography, Coronary Circulation, Echocardiography, Stress, Electrocardiography, Humans, Isolated Noncompaction of the Ventricular Myocardium diagnosis, Isolated Noncompaction of the Ventricular Myocardium drug therapy, Isolated Noncompaction of the Ventricular Myocardium physiopathology, Magnetic Resonance Imaging, Male, Microcirculation, Microvascular Angina diagnosis, Microvascular Angina etiology, Microvascular Angina physiopathology, Myocardial Infarction diagnosis, Myocardial Infarction drug therapy, Myocardial Infarction physiopathology, Thromboembolism etiology, Young Adult, Isolated Noncompaction of the Ventricular Myocardium complications, Myocardial Infarction etiology
- Abstract
Isolated left ventricular noncompaction (LVNC) is a rare hereditary cardiomyopathy characterized by prominent intraventricular trabeculations separated by deep intertrabecular recessus. While cardiac ischemia due to microvascular dysfunction is common in these patients, ST-segment elevation myocardial infarction (STEMI) is rare and usually seen as a consequence of coincidental coronary artery disease. We report the case of a 20 year-old male patient admitted to our emergency department with a complaint of squeezing chest pain who was subsequently diagnosed with STEMI according to electrocardiographic findings, although an emergent coronary angiogram demonstrated normal coronary arteries. Echocardiography revealed isolated LVNC, and the diagnosis was confirmed via magnetic resonance imaging. Repeat coronary catheterization with acetylcholine infusion and coronary flow reserve measurement failed to demonstrate vasospasm or microvascular dysfunction. As no apparent cause was found, this case was designated 'idiopathic' myocardial infarction. Coronary thromboembolism due to stagnation of blood in the left ventricular cavity remained as the most probable mechanism underlying myocardial infarction.
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- 2012
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14. Oxidative stress and severity of coronary artery disease in young smokers with acute myocardial infarction.
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Aksoy S, Cam N, Gurkan U, Oz D, Özden K, Altay S, Durmus G, and Agirbasli M
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- Adult, Age of Onset, Aryldialkylphosphatase blood, Biomarkers blood, Carboxylic Ester Hydrolases blood, Case-Control Studies, Coronary Angiography, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease metabolism, Cross-Sectional Studies, Female, Humans, Linear Models, Lipid Peroxides blood, Male, Multivariate Analysis, Myocardial Infarction diagnostic imaging, Myocardial Infarction metabolism, Predictive Value of Tests, Risk Assessment, Risk Factors, Severity of Illness Index, Smoking metabolism, Turkey, Coronary Artery Disease etiology, Myocardial Infarction etiology, Oxidative Stress, Smoking adverse effects
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Background: Cigarette smoking increases the oxidative stress mediated vascular dysfunction in young adults. We aimed to investigate the relation between the oxidative stress indices and coronary artery disease (CAD) severity in young patients presenting with acute myocardial infarction (AMI)., Methods: Young patients (aged 〈 35 years) who were admitted consecutively to our hospital with a diagnosis of AMI were included in the study. Age matched healthy subjects were selected as controls. Oxidative stress indices including lipid hydroperoxide (LOOH), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON) and arylesterase (ARE) activities were measured in serum. CAD severity was assessed by calculating the SYNTAX (Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery Study) score. We analyzed the association between the oxidative indices and CAD severity., Results: Forty two young patients were admitted to the hospital with AMI (age 32.4 ± 2.6 years; 39 males, 3 females). Current and heavy smoking was commonly observed among the patients (79%). All patients underwent emergency coronary angiography. Twenty-eight healthy subjects were selected as controls. Patients had significantly higher OSI and TOS levels (median, interquartile range) [0.44 (0.26-1.75) vs 0.25 (0.22-0.30), p < 0.001 and 6.0 (4.4-20.8) vs 4.1 (3.7-4.6), p < 0.001], respectively, and lower TAS and LOOH levels [1.6 ± 0.1 vs 1.7 ± 0.1, p = 0.02 and 3.0 ± 0.8 vs 3.6 ± 0.4, p = 0.001], respectively, compared to the control group. CAD severity correlated positively with OSI (r = 0.508, p = 0.001) and TOS levels (r = 0.471, p = 0.002). Subjects with an intermediate to high SYNTAX score (≥ 22) demonstrated significantly higher OSI (median, interquartile range) [0.40 (0.34-1.75) vs 0.34 (0.26-0.68), p = 0.01] and TOS [6.9 (4.4-20.8) vs 5.8 (4.5-11.4), p = 0.01] levels compared to subjects with low SYNTAX score., Conclusions: Oxidative stress is an important contributor to CAD severity among young smokers. Elevated OSI and TOS levels reflect disease severity and vascular damage related to heavy smoking in early onset CAD.
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- 2012
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15. Intramyocardial fissure.
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Velibey Y, Satılmış S, Cağdaş M, Altay S, Güzelburç O, Satılmış D, Yeşilçimen K, and Eren M
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- Adult, Diagnosis, Differential, Echinococcosis diagnosis, Echocardiography, Humans, Male, Myocardial Infarction complications, Myocardial Infarction pathology, Myocardium pathology
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- 2011
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16. Barnidipine intoxication causing acute myocardial infarction.
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Güvenç TS, Gürkan U, Güzelburç O, Ilhan E, and Altay S
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- Adult, Coronary Angiography, Electrocardiography, Female, Humans, Myocardial Infarction physiopathology, Nifedipine poisoning, Suicide, Attempted, Calcium Channel Blockers poisoning, Myocardial Infarction chemically induced, Nifedipine analogs & derivatives
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- 2010
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17. Baseline clinical characteristics and patient profile of the TURKMI registry: Results of a nation-wide acute myocardial infarction registry in Turkey
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Erol, M.K., Kayıkçıoğlu, M., Kılıçkap, M., Arın, C.B., Kurt, İ.H., Aktaş, İ., Güneş, Y., Özkan, E., Şen, T., İnce, O., Örnek, E., Asoğlu, R., Aladağ, N., Zeybey, U., Sinan, Ü.Y., Dural, M., Tüner, H., Doğan, A.C., Yenerçağ, M., Akboğa, M.K., Deveci, O.S., Somuncu, M.U., Inanir, M., Yalçin, O.Y., Genc, O., Yildirim, A., Asoglu, R., Inci, S., Ornek, E., Cetin, M., Kiziltunc, E., Yayla, C., Ertem, A.G., Akboga, M.K., Genc, A., Oztekin, G.M.Y., Gitmez, M., Tuncay, B., Can, V., Ari, H., Tatar, F.P., Gazi, E., Yeşildas, C., Er, O., Ozturk, O., Candemir, A., Kayikçioglu, M., Yavuzgil, O., Mirzaoğlu, C., Bakirci, E.M., Degirmenci, H., Besli, F., Ince, O., Hancıoglu, E., Akurk, I.F., Oflar, E., Çaglar, N.T., Halac, H.A.Y., Kalyoncuoglu, M., Balaban, I., Karatas, M., Kirma, C., Guler, A., Can, C., Dogan, A.C., Yalcin, A.A., Arin, C.B., Sinan, U.Y., Kücükokur, M., Ozdogan, O., Aksu, E., Günes, H., Simsek, Z., Ozkan, E., Sabanoğlu, C., Celik, Y., Sen, T., Astarcıoglu, M.A., Aktas, I., Gozubuyuk, G., Tigen, M.K., Sunbul, M., Arslan, A., Celik, A., Akkus, O., Alsancak, Y., Mert, K.U., Kose, N., Kılıç, İsmail Doğu, Emlek, N., Kocayigit, I., Yanik, A., Yenerçag, M., Çitrakoglu, O.F., Dursun, I., Altay, S., Baysal, S.S., Aladag, N., Sarikaya, R., Duz, R., Tuncer, M., Tuner, H., Ungan, I., Karaduman, B.D., Bozkurt, E., TURKMI study group, Ege Üniversitesi, and Tıp Fakültesi
- Subjects
Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Turkey ,medicine.medical_treatment ,Myocardial Infarction ,Angiotensin-Converting Enzyme Inhibitors ,030204 cardiovascular system & hematology ,Coronary Angiography ,Coronary artery disease ,0302 clinical medicine ,Ischemia ,Risk Factors ,Registries ,030212 general & internal medicine ,Myocardial infarction ,Original Investigation ,Aspirin ,education.field_of_study ,biology ,ST elevation ,Smoking ,Age Factors ,Middle Aged ,Hypertension ,Population study ,Female ,Cardiology and Cardiovascular Medicine ,medicine.drug ,medicine.medical_specialty ,Registry ,Adrenergic beta-Antagonists ,Hypercholesterolemia ,Population ,Hyperlipidemias ,Acute myocardial infarction ,0-Belirlenecek ,Angiotensin Receptor Antagonists ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Fibrinolytic Agents ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,education ,Aged ,business.industry ,Percutaneous coronary intervention ,Angiotensin-converting enzyme ,medicine.disease ,lcsh:RC666-701 ,biology.protein ,business ,Platelet Aggregation Inhibitors - Abstract
Objective: The TURKMI registry is designed to provide insight into the characteristics, management from symptom onset to hospital discharge, and outcome of patients with acute myocardial infarction (MI) in Turkey. We report the baseline and clinical characteristics of the TURKMI population. Methods: The TURKMI study is a nation-wide registry that was conducted in 50 centers capable of percutaneous coronary intervention selected from each EuroStat NUTS region in Turkey according to population sampling weight, prioritized by the number of hospitals in each region. All consecutive patients with acute MI admitted to coronary care units within 48 hours of symptom onset were prospectively enrolled during a predefined 2-week period between November 1, 2018 and November 16, 2018. Results: A total of 1930 consecutive patients (mean age, 62.0 +/- 13.2 years; 26.1% female) with a diagnosis of acute MI were prospectively enrolled. More than half of the patients were diagnosed with non-ST elevation MI (61.9%), and 38.1% were diagnosed with ST elevation MI. Coronary angiography was performed in 93.7% and, percutaneous coronary intervention was performed in 73.2% of the study population. Fibrinolytic therapy was administered to 13 patients (0.018%). Aspirin was prescribed in 99.3% of the patients, and 94% were on dual antiplatelet therapy at the time of discharge. Beta blockers were prescribed in 85.0%, anti-lipid drugs in 96.3%, angiotensin converting enzyme inhibitors in 58.4%, and angiotensin receptor blockers in 7.9%. Comparison with European countries revealed that TURKMI patients experienced MI at younger ages compared with patients in France, Switzerland, and the United Kingdom. The most prevalent risk factors in the TURKMI population were hypercholesterolemia (60.2%), hypertension (49.5%), smoking (48.8%), and diabetes (37.9%). Conclusion: The nation-wide TURKMI registry revealed that hypercholesterolemia, hypertension, and smoking were the most prevalent risk factors. TURKMI patients were younger compared with patients in European Countries. The TURKMI registry also confirmed that current treatment guidelines are largely adopted into clinical cardiology practice in Turkey in terms of antiplatelet, anti-ischemic, and anti-lipid therapy., Turkish Society of Cardiology; Astra-Zeneca CompanyAstraZeneca, TURKMI is an investigator-initiated study sponsored by the Turkish Society of Cardiology that receives major funding from Astra-Zeneca Company for this project.
- Published
- 2020
18. A novel and useful predictive indicator of prognosis in ST-segment elevation myocardial infarction, the prognostic nutritional index.
- Author
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Keskin, M., Hayıroğlu, M.İ., Keskin, T., Kaya, A., Tatlısu, M.A., Altay, S., Uzun, A.O., Börklü, E.B., Güvenç, T.S., Avcı, İ.İ., Kozan, Ö., Hayıroğlu, M I, Avcı, I I, and Altay, Servet
- Abstract
Background and Aim: The prognostic impact of poor nutritional status and cardiac cachexia in myocardial infarction is not clearly understood. Recent studies have implied a prognostic value of the prognostic nutritional index (PNI) in colorectal surgeries and postoperative septic complications. The present study aimed to evaluate the prognostic value of PNI in ST-segment elevation myocardial infarction (STEMI) patients.Methods and Results: We evaluated the in-hospital and long-term (3 years) prognostic impact of PNI on 1823 patients with STEMI undergoing primary percutaneous coronary intervention. Patients with lower PNI had significantly higher in-hospital and long-term mortality and major adverse cardiac events. After adjustment for all confounders, the in-hospital mortality rates were 7.9 times higher at the lower PNI level (95% CI: 5.0-15.8) than those at the higher PNI level. The long-term mortality rates were also 6.4 times higher at the lower PNI level (95% CI: 4.4-12.4) than those at the higher PNI level.Conclusion: The present study demonstrated that the PNI, calculated based on the serum albumin level and lymphocyte count, is an independent prognostic factor for mortality in patients with STEMI. [ABSTRACT FROM AUTHOR]- Published
- 2017
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