1. Long-term clearance of patch-stage mycosis fungoides with the 308-nm laser.
- Author
-
Upjohn E, Foley P, Lane P, Magee J, Prince HM, McCormack C, and Sinclair R
- Subjects
- Adolescent, Adult, Aged, Biopsy, Female, Humans, Lymphoma, T-Cell, Cutaneous pathology, Male, Middle Aged, Mycosis Fungoides pathology, Prospective Studies, Skin Neoplasms pathology, Treatment Outcome, Laser Therapy methods, Lymphoma, T-Cell, Cutaneous surgery, Mycosis Fungoides surgery, Skin Neoplasms surgery
- Abstract
In order to investigate the effectiveness of the 308-nm xenon chloride laser in the treatment of patch-stage mycosis fungoides that is refractory to topical steroids, we conducted a prospective, histologically controlled, open-label pilot study. Eight patients with stage 1A or 1B cutaneous T-cell lymphoma that was unresponsive to application of potent topical steroids received 20 treatments with the laser over 10 weeks and were then followed up for a minimum of 30 months. Three patients had a complete clinical and histological response and remained free of disease after 30 months A further three patients had complete clinical and histological clearance of disease, but experienced relapse within the 30 months follow-up period. One patient withdrew from the study and one had a partial response. Further research to establish the role of the 308-nm laser in the treatment of MF appears justified.
- Published
- 2007
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