1. A 12-year study of fungal infections in Rio Grande do Sul, Southern Brazil.
- Author
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Fay VDS, Gregianini TS, Veiga ABGD, Gonçalves SMB, Rodrigues DM, and Bonamigo RR
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Antifungal Agents therapeutic use, Brazil epidemiology, Candida drug effects, Candida isolation & purification, Candida albicans isolation & purification, Candidiasis epidemiology, Candidiasis microbiology, Child, Child, Preschool, Cryptococcosis epidemiology, Cryptococcosis microbiology, Cryptococcus neoformans isolation & purification, Female, Fluconazole therapeutic use, HIV Seronegativity, HIV Seropositivity epidemiology, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Microbial Sensitivity Tests, Middle Aged, Mycoses microbiology, Onychomycosis epidemiology, Onychomycosis microbiology, Prevalence, Retrospective Studies, Sex Distribution, Time Factors, Young Adult, Mycoses epidemiology
- Abstract
Background: The number of fungal infections has increased in recent years in Rio Grande do Sul (RS), Brazil. Epidemiological studies are important for proper control of infections., Aims: To evaluate the etiology of fungal infections in patients in RS, from 2003 to 2015., Methods: This is a retrospective and longitudinal study carried out at Mycology Department of Central Laboratory of RS; 13,707 samples were evaluated. The variables sex, age, site of infection, and etiologic agent were analyzed. Susceptibility of Candida to fluconazole was tested in isolates from samples collected in 2015 from 51 outpatients., Results: Of the 13,707 samples, 840 cases (6.12%) of fungal infections were found and included in the analyses; female gender accounted for the 55.9% of the cases. The main fungus was Candida albicans (450 cases, 53.38%; p<0.001). Onychomycosis was the most frequent infection in superficial mycoses. Systemic mycoses accounted for 54.05% of the cases, from which 68.8% occurred in males, mainly HIV-positive (33.11%), and the main etiologic agent in these cases was Cryptococcus neoformans (73.13%). Among 51 samples tested for susceptibility to fluconazole, 78.43% of Candida isolates were susceptible; 5.88% were susceptible in a dose-dependent manner, and 15.69% were resistant., Conclusions: C. albicans is a common cause of fungal infections in RS, accounting for half of the cases; resistance to antifungals was found in non-hospitalized patients. In addition, women seem to be more susceptible to fungal infections than men, however men show more systemic mycoses than women. The nails are the most common site of infection., (Copyright © 2019 Asociación Española de Micología. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2019
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