1. In vitro antibacterial activity of AZD0914 against human Mycoplasmas and Ureaplasmas.
- Author
-
Waites KB, Crabb DM, Duffy LB, and Huband MD
- Subjects
- Azithromycin pharmacology, Doxycycline pharmacology, Humans, Isoxazoles, Levofloxacin pharmacology, Microbial Sensitivity Tests, Morpholines, Mycoplasma genitalium drug effects, Mycoplasma pneumoniae drug effects, Oxazolidinones, Anti-Bacterial Agents pharmacology, Barbiturates pharmacology, Mycoplasma drug effects, Spiro Compounds pharmacology, Ureaplasma drug effects
- Abstract
In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma pneumoniae. The AZD0914 MIC90 against Mycoplasma hominis was 8-fold greater than that for levofloxacin. The AZD0914 MIC90 against Ureaplasma species was 4-fold less than that for azithromycin and 8-fold less than that for levofloxacin and doxycycline., (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Published
- 2015
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