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Abstract: The synthesis and characterization of ruthenium compounds of the type [RuCl2(P)2(N–N)] [(P)2 =(PPh3)2, dppb=1,4-bis(diphenylphosphino)butano; dppp=1,3-bis(diphenylphosphino)propane; N–N=5,5′-dimethyl-2,2′dipyridyl (5,5′-mebipy) or 4,4′-dimethyl-2,2′dipyridyl (4,4′-mebipy)] are described. The complexes were characterized using elemental analysis, UV–Vis and infrared spectroscopies, cyclic voltammetry, and X-ray crystallography. In vitro evaluation of the complexes, using the MTT methodology, revealed their cytotoxic activities in a range of 5.4–15.7μM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The in vitro antimycobacterial activities of the complexes had their Minimum Inhibitory Concentration (MIC) for MTB cell growth measured, by the REMA method. The MICs for these complexes were found to be between 12.5 and 25.0μg/mL. The results are comparable with the “second line” drug cycloserine (MIC=12.5–50.0μg/mL), commonly used in the treatment of TB. [Copyright &y& Elsevier]

Abstract: Twenty-three naphthoimidazoles and six naphthoxazoles were synthesised and evaluated against susceptible and rifampicin- and isoniazid-resistant strains of Mycobacterium tuberculosis. Among all the compounds evaluated, fourteen presented MIC values in the range of 0.78 to 6.25μg/mL against susceptible and resistant strains of M. tuberculosis. Five structures were solved by X-ray crystallographic analysis. These substances are promising antimycobacterial prototypes. [Copyright &y& Elsevier]