1. In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor.
- Author
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Huitric E, Verhasselt P, Andries K, and Hoffner SE
- Subjects
- ATP Synthetase Complexes genetics, ATP Synthetase Complexes metabolism, Amino Acid Sequence, Diarylquinolines, Drug Resistance, Bacterial, Microbial Sensitivity Tests, Molecular Sequence Data, Mycobacterium tuberculosis enzymology, Mycobacterium tuberculosis genetics, Polymorphism, Genetic, Sequence Homology, Amino Acid, ATP Synthetase Complexes antagonists & inhibitors, Antitubercular Agents pharmacology, Mycobacterium tuberculosis drug effects, Quinolines pharmacology
- Abstract
The diarylquinoline R207910 is in clinical development for tuberculosis treatment. The MIC(50) for 41 drug-susceptible and 44 multidrug-resistant Mycobacterium tuberculosis clinical isolates was 0.032 microg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R207910 and were shown to exhibit a polymorphism in their atpE genes.
- Published
- 2007
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