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Wearable electronic sensors have attracted extensive attention in multifunctional electronic skin, personalized health monitoring, intelligent human–machine interaction, and smart medical treatment. However, critical challenge exists in simultaneously achieving excellent sensing performances with high sensitivity, rapid response, low sensing limit, and excellent cycling stability for full‐scale human healthcare detection and further timely photothermal therapy. For highly sensitive human skin, the spinosum microstructure in epidermis and dermis takes an important part in sensing signal amplification and transmission. Inspired by the spinosum microstructure of human skin for highly sensitive tactile perception, a skin‐inspired flexible electronic sensor is prepared from the face‐to‐face assembly of an as‐prepared polybutylene adipate‐polyurethane (PBAPU) elastomer matrix with conducting MXene nanosheets‐coated urchin‐like microstructure templated from natural chrysanthemum pollen grain microstructures, and an interdigitated electrode‐coated PBAPU elastomer substrate. The PBAPU elastomer matrix is newly prepared, exhibiting outstanding tensile strength (18.87 MPa), high stretchability (1190%), and comparable elastic modulus (1.7 MPa) to human skin. The as‐assembled flexible electronic sensor exhibits a highly sensitive sensitivity (up to 784.02 kPa−1), low detection limit (0.12 Pa), and reliable cycling stability for intelligent human–machine interfacing. The MXene nanosheets‐coated urchin‐like microstructure‐contained PBAPU possesses efficient photothermal heating performance to achieve on‐demand photothermal therapy for rehabilitation training. [ABSTRACT FROM AUTHOR]

Conductive hydrogel‐based epidermal sensors are regarded with broad prospects in bridging the gap between human and machine for personalized healthcare. However, it is still challenging to simultaneously achieve high sensitivity, wide sensing range, and reliable cycling stability in hydrogel‐based epidermal sensors for ultrasensitive human–machine interfacing, along with brilliant antiswelling capability, and near‐infrared (NIR) light‐triggered dissociation and drug release for further smart on‐demand photothermal therapy. Herein, the facile preparation of a flexible multifunctional epidermal sensor from the elaborately fabricated, highly stretchable, and antiswelling MXene hydrogel is presented. It exhibits high sensitivity, wide sensing range (up to 350% strain), and reliable reproducibility for enabling ultrasensitive human‐machine interfacing. It displays excellent antiswelling capability for the hydrogel to avoid expanding the wound due to excessive swelling for further reliable wound therapy. Furthermore, it possesses good biocompatibility and robust photothermal performance for the smart photothermal therapy after healthcare monitoring. Meanwhile, the sensor can be triggered to be softened and partly dissociated under the prolonged NIR light irradiation with the transformation of the temperature‐sensitive low‐melting‐point Agar into a sol state and the partial dissociation in the hydrogel to release the loaded drug on demand for synergistically sterilizing bacteria and efficiently promoting wound healing. [ABSTRACT FROM AUTHOR]

Flexible epidermic sensors made from conductive hydrogels are holding bright potential in personalized healthcare, multifunctional electronic skins, and human‐machine interfaces. However, it is still a great challenge to simultaneously realize conductive hydrogel‐based epidermic sensors with reliable self‐healing ability and remarkable sensing performances in high‐performance healthcare (especially electrophysiological signals) sensing for wearable human‐machine interaction, as well as accelerated wound healing for subsequent medical treatment together. Herein, a flexible healable high‐performance epidermic sensor is assembled from the facilely prepared antibacterial MXene hydrogel with efficiently accelerated wound healing for sensitively wearable human‐machine interaction. The as‐prepared hydrogel possesses enhanced mechanical performance, outstanding healable capability, reliable injectability, facile degradability, excellent biocompatibility, and robust antibacterial ability, which is capable of being assembled into a multifunctional epidermic sensor to sensitively monitor human movements for rehabilitation training, to detect tiny electrophysiological signals for the diagnosis of cardiovascular‐ and muscle‐related diseases, and to be employed for wearable human‐machine interaction. In addition, the hydrogel can be utilized to treat wound infection and can effectively accelerate wound healing. Thus, it sheds light on preparing flexible healable epidermic sensors with multifunctional integration of personal health diagnosis and smart medical treatment for wearable human‐machine interaction and next‐generation artificial skins. [ABSTRACT FROM AUTHOR]