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2 results on '"wt sod1"'

1. The effects of wild-type and mutant SOD1 on smooth muscle contraction

Author

Nikolić-Kokić Aleksandra, Oreščanin-Dušić Zorana, Spasojević Ivan, Blagojević Duško, Stević Zorica, Anđus Pavle, and Spasić Mihajlo

Subjects
FALS, mutation, G93A SOD1, WT SOD1, muscle relaxation, Biology (General), QH301-705.5
Abstract

In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS. [Projekat Ministarstva nauke Republike Srbije, br. 173014 i br. 175083]

Published
2015
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2. The effects of wild-type and mutant SOD1 on smooth muscle contraction

Author

Zorana Oreščanin-Dušić, Ivan Spasojevic, Mihajlo B. Spasić, Aleksandra Nikolić-Kokić, Pavle Anđus, Duško Blagojević, and Zorica Stevic

Subjects
medicine.medical_specialty, G93A SOD1, animal diseases, SOD1, Isometric exercise, General Biochemistry, Genetics and Molecular Biology, Superoxide dismutase, WT SOD1, Internal medicine, medicine, Amyotrophic lateral sclerosis, lcsh:QH301-705.5, biology, Chemistry, Wild type, nutritional and metabolic diseases, Smooth muscle contraction, medicine.disease, Enzyme assay, nervous system diseases, Muscle relaxation, Endocrinology, muscle relaxation, lcsh:Biology (General), nervous system, biology.protein, FALS, mutation, General Agricultural and Biological Sciences
Abstract

In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS. [Projekat Ministarstva nauke Republike Srbije, br. 173014 i br. 175083]

Published
2015

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