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Your search keyword '"Borras, Ana M"' showing total 2 results
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2 results on '"Borras, Ana M"'

1. Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib.

Author

Jackman DM, Holmes AJ, Lindeman N, Wen PY, Kesari S, Borras AM, Bailey C, de Jong F, Jänne PA, and Johnson BE

Subjects
Antineoplastic Agents administration & dosage, Antineoplastic Agents blood, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung secondary, ErbB Receptors drug effects, Gefitinib, Humans, Lung Neoplasms genetics, Lung Neoplasms pathology, Male, Meningeal Neoplasms genetics, Meningeal Neoplasms secondary, Middle Aged, Protein Kinase Inhibitors therapeutic use, Quinazolines administration & dosage, Quinazolines blood, Treatment Outcome, Antineoplastic Agents therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Drug Resistance, Neoplasm, ErbB Receptors genetics, Lung Neoplasms drug therapy, Meningeal Neoplasms drug therapy, Mutation, Quinazolines therapeutic use
Published
2006
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2. Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing.

Author

Thomas RK, Nickerson E, Simons JF, Jänne PA, Tengs T, Yuza Y, Garraway LA, LaFramboise T, Lee JC, Shah K, O'Neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, DeBiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Brockman W, Alvarez P, Hutchison SK, Leamon JH, Ronan MT, Turenchalk GS, Egholm M, Sellers WR, Rothberg JM, and Meyerson M

Subjects
Base Sequence, Humans, Molecular Sequence Data, Neoplasms diagnosis, Sensitivity and Specificity, Chromosome Mapping methods, DNA, Neoplasm genetics, Mutation, Neoplasms genetics
Abstract

The sensitivity of conventional DNA sequencing in tumor biopsies is limited by stromal contamination and by genetic heterogeneity within the cancer. Here, we show that microreactor-based pyrosequencing can detect rare cancer-associated sequence variations by independent and parallel sampling of multiple representatives of a given DNA fragment. This technology can thereby facilitate accurate molecular diagnosis of heterogeneous cancer specimens and enable patient selection for targeted cancer therapies.

Published
2006
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