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Background: The handgrip strength (HGS) is an indicator of muscle strength associated with several health outcomes in adolescents and adults. This cross-sectional study aimed to identify HGS levels and associated modifiable and non-modifiable risk factors in adolescents., Methods: The study included 971 adolescents (496 boys) aged 15-18 years. The HGS was measured by a dynamometer, and the maximum value of right and left hands were summed for a total score. Age, economic status, balanced diet, physical activity, and sedentary behavior were assessed by questionnaires, while body mass index was determined by measuring body weight and height. Multiple linear regression was carried out to examine the association., Results: 65.4% of the adolescents presented low levels of HGS (boys: 73.8%; girls: 56.6%). Low levels of HGS were associated with weight status and height in both sexes. In boys, low levels of HGS were associated with age, balanced diet, physical activity, and sedentary behavior., Conclusion: About six out of ten adolescentes presented low levels of HGS. The main predictors of low levels of HGS in boys were age, physical activity, sedentary behavior, and balanced diet, and weight status and height in both sexes., Competing Interests: Declaration of competing interest Author MAB declares that he has no conflict of interest. Author AAP declares that he has no conflict of interest. Author KSS declares that she has no conflict of interest. Author GSC declares that she has no conflict of interest. Author AP declares that she has no conflict of interest., (Copyright © 2021 Elsevier Ltd. All rights reserved.)