1. Relationship between serum levels of tumour necrosis factor-related apoptosis-inducing ligand and the survival of Chinese peritoneal dialysis patients.
- Author
-
POON, PETER YAM-KAU, SZETO, CHEUK-CHUN, KWAN, BONNIE CHING-HA, CHOW, KAI-MING, LEUNG, CHI-BON, and LI, PHILIP KAM-TAO
- Subjects
- *
TUMOR necrosis factors , *APOPTOSIS , *PERITONEAL dialysis , *LIGANDS (Biochemistry) , *MULTIVARIATE analysis , *ATHEROSCLEROSIS , *PATIENTS - Abstract
ABSTRACT Aim: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can counteract inflammation and atherosclerosis, both common causes of morbidity in peritoneal dialysis (PD) patients. We examined the relation between serum soluble TRAIL (sTRAIL) levels and the outcome of Chinese PD patients. Methods: We studied 116 new PD patients (67 males, age 56.7 ± 13.4 years). Baseline serum sTRAIL level was determined and grouped to tertiles 1 (lowest) to 3 (highest). All patients were followed for 20.9 ± 7.0 months. Results: Patient survival was 83.4%, 74.2% and 100% for tertiles 1 to 3, respectively, at 24 months ( P = 0.021). Multivariate Cox regression analysis showed that serum sTRAIL level was an independent predictor of patient survival after adjusting for confounding factors (adjusted hazard ratio 0.962, 95% confidence interval [CI] 0.935-0.991, P = 0.010). Conclusion: A higher baseline serum sTRAIL level was associated with a better survival of PD patients. The detailed mechanism deserves further investigation. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF