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Relevance. Patients with multiple lower extremity trauma are the group of a very high risk for the development of venous thromboembolism. Therefore, they need a set of measures to prevent this complication. The risk of developing hemorrhagic complications in the I–III periods of traumatic disease prevents many physicians from prescribing anticoagulants. In addition, the application of the external fixation apparatus makes the use of mechanical blood flow acceleration (elastic bandages, compression knitwear, intermittent pneumatic compression) impossible. The purpose of the study is to evaluate the effectiveness and safety of electric muscle stimulation (EMS) for venous thromboembolism prevention in the patients with multiple trauma and the use of external fixation for the lower limb fractures. Material and Methods. The analysis of treatment results of 31 patients with multiple lower limb trauma with the use of external fixation was carried. All the patients were men with average age of 29.3±5.1 years. The patients were divided into two groups by stratified randomization. The groups were comparable by sex, age, body weight, and injury severity. The patients of main group received EMS, in control group — the authors did not use the mentioned treatment. The EMS was carried out using a Veinoplus DVT according to the scheme: 60 min morning, afternoon and evening. Vascular ultrasonography of the lower extremities was performed for all patients before EMS and then every 7 days, as well as before each surgery. All patients underwent venous thromboembolism prevention with low molecular weight heparins, followed by switching to oral anticoagulants. Results. Side effects associated with the use of the EMS, as well as hemorrhagic complications were not detected. The velocity of blood flow in the popliteal vein in the patients, received EMS, was 9.7 ± 0.7 cm/s before the session and 17.0±1.1 cm/s during the session (p