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Start Over Descriptor "RGS7" Topic multiple sclerosis
2 results on '"RGS7"'

1. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis

Author

McCauley, JL, Zuvich, RL, Bradford, Y, Kenealy, SJ, Schnetz-Boutaud, N, Gregory, SG, Hauser, SL, Oksenberg, JR, Mortlock, DP, Pericak-Vance, MA, and Haines, JL

Subjects
Biological Sciences, Genetics, Prevention, Brain Disorders, Multiple Sclerosis, Human Genome, Arthritis, Autoimmune Disease, Neurosciences, Neurodegenerative, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Neurological, Alleles, Chromosomes, Human, Pair 1, Female, Follow-Up Studies, Gene Frequency, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Humans, Male, Polymorphism, Single Nucleotide, RGS Proteins, multiple sclerosis, linkage, association, 1q43, RGS7, Immunology
Abstract

Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease affecting >4,00,000 individuals in the United States. Population and family-based studies have suggested that there is a strong genetic component. Numerous genomic linkage screens have identified regions of interest for MS loci. Our own second-generation genome-wide linkage study identified a handful of non-major histocompatibility complex regions with suggestive linkage. Several of these regions were further examined using single-nucleotide polymorphisms (SNPs) with average spacing between SNPs of approximately 1.0 Mb in a dataset of 173 multiplex families. The results of that study provided further evidence for the involvement of the chromosome 1q43 region. This region is of particular interest given linkage evidence in studies of other autoimmune and inflammatory diseases including rheumatoid arthritis and systemic lupus erythematosus. In this follow-up study, we saturated the region with approximately 700 SNPs (average spacing of 10 kb per SNP) in search of disease-associated variation within this region. We found preliminary evidence to suggest that common variation within the RGS7 locus may be involved in disease susceptibility.

Published
2009

2. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis

Author

Douglas P. Mortlock, Stephen L. Hauser, Jacob L. McCauley, Shannon J. Kenealy, Jorge R. Oksenberg, Jonathan L. Haines, Nathalie Schnetz-Boutaud, Yuki Bradford, Simon G. Gregory, Margaret A. Pericak-Vance, and Rebecca L. Zuvich

Subjects
Male, 1q43, Multiple Sclerosis, Genotype, Genetic Linkage, Immunology, Population, Single-nucleotide polymorphism, Locus (genetics), Biology, Polymorphism, Single Nucleotide, Chromosomes, Article, Gene Frequency, Genetic linkage, Genetic variation, Genetics, SNP, Humans, Genetic Predisposition to Disease, Polymorphism, Allele, education, Allele frequency, Genetics (clinical), Alleles, education.field_of_study, association, Single Nucleotide, Chromosomes, Human, Pair 1, Pair 1, Female, RGS7, linkage, RGS Proteins, Human, Follow-Up Studies
Abstract

Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease affecting >4,00,000 individuals in the United States. Population and family-based studies have suggested that there is a strong genetic component. Numerous genomic linkage screens have identified regions of interest for MS loci. Our own second-generation genome-wide linkage study identified a handful of non-major histocompatibility complex regions with suggestive linkage. Several of these regions were further examined using single-nucleotide polymorphisms (SNPs) with average spacing between SNPs of approximately 1.0 Mb in a dataset of 173 multiplex families. The results of that study provided further evidence for the involvement of the chromosome 1q43 region. This region is of particular interest given linkage evidence in studies of other autoimmune and inflammatory diseases including rheumatoid arthritis and systemic lupus erythematosus. In this follow-up study, we saturated the region with approximately 700 SNPs (average spacing of 10 kb per SNP) in search of disease-associated variation within this region. We found preliminary evidence to suggest that common variation within the RGS7 locus may be involved in disease susceptibility.

Published
2009

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