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Your search keyword '"Deyneko IV"' showing total 2 results
Start Over Author "Deyneko IV" Topic multiple sclerosis
2 results on '"Deyneko IV"'

1. Evaluation of variation in genes of the arylhydrocarbon receptor pathway for an association with multiple sclerosis.

Author

Zorlu N, Hoffjan S, Haghikia A, Deyneko IV, and Epplen JT

Subjects
Adult, Case-Control Studies, Cohort Studies, Female, Genetic Association Studies methods, Humans, Male, Middle Aged, Basic Helix-Loop-Helix Transcription Factors genetics, Genetic Variation genetics, Multiple Sclerosis diagnosis, Multiple Sclerosis genetics, Polymorphism, Single Nucleotide genetics, Receptors, Aryl Hydrocarbon genetics
Abstract

The aryl hydrocarbon receptor (AhR) contributes to immune regulation in autoimmune diseases such as multiple sclerosis (MS). Analysis of selected polymorphisms in AhR pathway genes in 805 MS patients and 1023 controls revealed a modest association of a CYP1B1 polymorphism with secondary progressive MS that became more pronounced in combination with other SNPs in the pathway, suggesting interactive effects. Additionally, first evidence for an interaction with smoking was found, but due to small sample sizes statistical significance was only nominal. Confirmation of these results in independent cohorts is recommended, since targeting the AhR constitutes a therapeutic option for autoimmune diseases., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2019
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2. Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients.

Author

Varzari A, Bruch K, Deyneko IV, Chan A, Epplen JT, and Hoffjan S

Subjects
Adaptor Proteins, Signal Transducing genetics, Adult, DEAD Box Protein 58, Female, Genetic Association Studies, Genotype, Germany, Humans, Interferon-Induced Helicase, IFIH1, Male, Middle Aged, RNA Helicases genetics, Receptors, Immunologic, DEAD-box RNA Helicases genetics, Genetic Predisposition to Disease genetics, Multiple Sclerosis genetics, Polymorphism, Single Nucleotide genetics
Abstract

Variation in genes encoding retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs) has been implicated in the pathogenesis of autoimmune disorders. We investigated if polymorphisms in the IFIH1, RIG-I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 patients and 706 controls. Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset. Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-I, LGP2 and IFIH1 genes on MS risk., (Copyright © 2014 Elsevier B.V. All rights reserved.)

Published
2014
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