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Your search keyword '"Dessi, M"' showing total 4 results
Start Over Author "Dessi, M" Topic multiple sclerosis
4 results on '"Dessi, M"'

1. Multiple Sclerosis: kFLC index values related to gender.

Author

Pieri M, Zenobi R, Morello M, Storto M, Buttari F, Centonze D, Bernardini S, and Dessi M

Subjects
Adult, Aged, Biomarkers blood, Biomarkers cerebrospinal fluid, Female, Humans, Immunoglobulin kappa-Chains blood, Immunoglobulin kappa-Chains cerebrospinal fluid, Male, Middle Aged, Multiple Sclerosis blood, Multiple Sclerosis cerebrospinal fluid, Sensitivity and Specificity, Sex Factors, Immunoglobulin kappa-Chains analysis, Multiple Sclerosis diagnosis
Abstract

Background: Multiple sclerosis (MS) is a chronic multifactorial inflammatory and neurodegenerative disease of the central nervous system (CNS). The identification of biomarkers with good diagnostic and prognostic power is of great importance for monitoring and treating MS patients., Methods: We analyzed serum and cerebrospinal fluid of 228 patients, with different neurological disorders and with MS to confirm our previous results and determine a possible gender difference of kFLC Index cut-off., Results: We have obtained a kFLC Index cut-off of 12.5 (100% specificity and 90.4% sensitivity) and 11 (100% specificity and 97.5% sensitivity) for women and men with MS respectively., Conclusions: This study reinforces the importance that kFLC Index could have as a diagnostic aid to detect MS. Our data highlight a difference in the cut-off of the kFLC Index calculated by gender; male patients with a kFLC Index value greater than 11 are at higher risk to develop MS respect females having the same result., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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2. KFLC Index utility in multiple sclerosis diagnosis: Further confirmation.

Author

Pieri M, Storto M, Pignalosa S, Zenobi R, Buttari F, Bernardini S, Centonze D, and Dessi M

Subjects
Biomarkers blood, Biomarkers cerebrospinal fluid, Humans, Magnetic Resonance Imaging, Multiple Sclerosis diagnostic imaging, Nervous System Diseases blood, Nervous System Diseases cerebrospinal fluid, Nervous System Diseases diagnostic imaging, Oligoclonal Bands blood, Oligoclonal Bands cerebrospinal fluid, Immunoglobulin Light Chains blood, Immunoglobulin Light Chains cerebrospinal fluid, Multiple Sclerosis blood, Multiple Sclerosis cerebrospinal fluid
Abstract

The Multiple Sclerosis (MS) diagnosis is based on dissemination of focal lesions in time and space. The free light chains (FLCs) determination might be a sensitive alternative to oligoclonal bands assay. The study aim was to redefine sensitivity, specificity of the kFLC Index cut-off. We analyzed serum and cerebrospinal fluid of 176 patients, with different neurological disorders. We obtained a cut off of 12,3 for kFLC Index with a sensitivity and specificity of 93% and 100% respectively. Our data confirm that the kFLC Index is a valid tool in the diagnosis of MS., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Published
2017
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3. Determination of κFLC and κ Index in cerebrospinal fluid: a valid alternative to assess intrathecal immunoglobulin synthesis.

Author

Duranti F, Pieri M, Centonze D, Buttari F, Bernardini S, and Dessi M

Subjects
Adult, Aged, Biomarkers blood, Biomarkers cerebrospinal fluid, Female, Humans, Immunoglobulin kappa-Chains blood, Injections, Spinal, Male, Middle Aged, Multiple Sclerosis diagnosis, Reproducibility of Results, Severity of Illness Index, Young Adult, Immunoglobulin kappa-Chains biosynthesis, Immunoglobulin kappa-Chains cerebrospinal fluid, Multiple Sclerosis cerebrospinal fluid, Multiple Sclerosis immunology, Oligoclonal Bands biosynthesis, Oligoclonal Bands blood, Oligoclonal Bands cerebrospinal fluid
Abstract

Intrathecal immunoglobulin synthesis is observed in several disorders of the central nervous system, but its detection by current laboratory tests is relatively insensitive and operator depending. We assessed the diagnostic accuracy of a nephelometric assay for k free light chain determination in cerebrospinal fluid and serum. The patients were grouped according to clinical and laboratory criteria. ROC curves for all methods were performed to find the best cut-off value. kFLC Index seems to be more accurate than other parameters. Our data indicate that nephelometric assay for kFLCs in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate multiple sclerosis patients., (© 2013.)

Published
2013
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