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Many workers claim variations in quantity of functional activity of several components in the complement system in M.S. patients. Studies were performed in 58 M.S. patients, typing for HLA-SD specifities and C'3 complement component. We have been able to confirm a significant correlation between the hypocomplementaemic group (31.03%) with HLA-A3. In this connection we present some considerations on complement system and M.S.

Field et al. have recently suggested a blood test for multiple sclerosis based on determination of the absolute electrophoretic mobility of erythrocytes alone and in the presence of linoleic acid (LA) or arachidonic acid (AA). We attempted to reinvestigate this phenomenon in an Italian population.

The biochemical features of lipid metabolism in multiple sclerosis are discussed and the contribution made by work on the aetiopathogenesis of the disease is illustrated. Reference is made to diagnostic tests (E-UFA and MEM tests), whose premisses are based on lipid metabolism. A link between biochemical and immunological research in this field is put forward.

The present studies were performed as a result of the report that the human T-cells may be composed of heterogeneous subpopulation in the sense of their ability to bind SRBC. In this paper, the diversity of human peripheral lymphocytes in M.S. patients, other neurological diseases and controls were investigated by means of an interesting approach based on the heterogeneity of humnan T-lymphocytes examined by the rosette formation of SRBC (E rosette) in two different reaction media.