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Start Over Author "Fredj NB" Topic multiple sclerosis, relapsing-remitting
2 results on '"Fredj NB"'

1. Role of HLA-G 14bp deletion/insertion and +3142C>G polymorphisms in the production of sHLA-G molecules in relapsing-remitting multiple sclerosis.

Author

Rizzo R, Bortolotti D, Fredj NB, Rotola A, Cura F, Castellazzi M, Tamborino C, Seraceni S, Baldi E, Melchiorri L, Tola MR, Granieri E, Baricordi OR, and Fainardi E

Subjects
Adult, Alleles, Female, Gene Frequency, Genotype, HLA-G Antigens blood, HLA-G Antigens cerebrospinal fluid, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting diagnosis, HLA-G Antigens genetics, Multiple Sclerosis, Relapsing-Remitting genetics, Multiple Sclerosis, Relapsing-Remitting metabolism, Mutagenesis, Insertional, Polymorphism, Single Nucleotide, Sequence Deletion
Abstract

HLA-G is believed to act as an anti-inflammatory molecule in Multiple Sclerosis (MS). The 3' untranslated region of the HLA-G gene is characterized by two polymorphisms, DEL/INS14bp and +3142C>G, which control soluble HLA-G (sHLA-G) production. The influence of these two HLA-G variants on sHLA-G serum and cerebrospinal fluid (CSF) levels was investigated in 69 Relapsing-Remitting MS patients grouped in magnetic resonance imaging (MRI) inactive and active disease. Serum and CSF sHLA-G levels were more elevated in high than in low DEL/INS 14bp and +3142C>G sHLA-G producers and were different among the various combined HLA-G genotypes in both MRI inactive and active diseases. The highest and the lowest sHLA-G values were identified in MS patients with C/C,DEL/DEL and G/G,INS/INS genotypes, respectively. Our preliminary findings suggest that serum and CSF sHLA-G levels in MS could be influenced by HLA-G polymorphisms irrespective of the inflammatory microenvironment., (Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)

Published
2012
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2. Role of HLA-G 14bp deletion/insertion and +3142C>G polymorphisms in the production of sHLA-G molecules in relapsing-remitting multiple sclerosis

Author

Loredana Melchiorri, Silva Seraceni, Maria Rosaria Tola, Daria Bortolotti, Massimiliano Castellazzi, Roberta Rizzo, Enrico Fainardi, Eleonora Baldi, Enrico Granieri, Antonella Rotola, Francesca Cura, Nadia Ben Fredj, Olavio R. Baricordi, Carmine Tamborino, Rizzo R, Bortolotti D, Fredj NB, Rotola A, Cura F, Castellazzi M, Tamborino C, Seraceni S, Baldi E, Melchiorri L, Tola MR, Granieri E, Baricordi OR, and Fainardi E

Subjects
Adult, Male, Untranslated region, Genotype, Immunology, HLA-G, Human leukocyte antigen, Biology, multiple sclerosis, Polymorphism, Single Nucleotide, NO, Multiple Sclerosis, Relapsing-Remitting, Cerebrospinal fluid, Gene Frequency, medicine, Humans, Immunology and Allergy, Allele, Allele frequency, Alleles, Sequence Deletion, HLA-G Antigens, Multiple sclerosis, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Molecular biology, Mutagenesis, Insertional, multiple sclerosi, Female, polymorphisms
Abstract

HLA-G is believed to act as an anti-inflammatory molecule in Multiple Sclerosis (MS). The 3′ untranslated region of the HLA-G gene is characterized by two polymorphisms, DEL/INS14bp and +3142C>G, which control soluble HLA-G (sHLA-G) production. The influence of these two HLA-G variants on sHLA-G serum and cerebrospinal fluid (CSF) levels was investigated in 69 Relapsing-Remitting MS patients grouped in magnetic resonance imaging (MRI) inactive and active disease. Serum and CSF sHLA-G levels were more elevated in high than in low DEL/INS 14bp and +3142C>G sHLA-G producers and were different among the various combined HLA-G genotypes in both MRI inactive and active diseases. The highest and the lowest sHLA-G values were identified in MS patients with C/C,DEL/DEL and G/G,INS/INS genotypes, respectively. Our preliminary findings suggest that serum and CSF sHLA-G levels in MS could be influenced by HLA-G polymorphisms irrespective of the inflammatory microenvironment.

Published
2012

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