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2 results on '"Haralampos S"'

1. Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential.

Author

Zorzos HS, Lazaris AC, Korkolopoulou PA, Kavantzas NG, Tseleni-Balafouta S, Patsouris ES, Tsavaris NV, and Davaris PS

Subjects
Adenocarcinoma secondary, Adenoma metabolism, Adenoma pathology, Adult, Aged, Antigens, Neoplasm, Biomarkers, Tumor, Colonic Neoplasms pathology, DNA-Binding Proteins, Drug Resistance, Multiple physiology, Female, Humans, Immunoenzyme Techniques, Lymph Nodes metabolism, Lymph Nodes pathology, Lymphatic Metastasis physiopathology, Male, Middle Aged, Neoplasm Invasiveness, ATP Binding Cassette Transporter, Subfamily B metabolism, Adenocarcinoma metabolism, Colonic Neoplasms metabolism, DNA Topoisomerases, Type II metabolism, Multidrug Resistance-Associated Proteins metabolism
Abstract

Aims: To investigate the role of multidrug resistance proteins and topoisomerase IIalpha in colon cancer., Methods: Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIalpha in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients., Results: P-glycoprotein was associated with the presence of lymph node metastasis (P=0.005), vessel invasion (P=0.0001) and perineural invasion (P=0.020)., Conclusions: P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination.

Published
2003
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2. Multidrug resistance proteins and topoisomerase IIα expression in colon cancer: association with metastatic potential

Author

Panagiotis Davaris, Efstratios Patsouris, Haralampos S. Zorzos, Andreas C. Lazaris, Sofia Tseleni-Balafouta, Nikolaos V. Tsavaris, Penelope Korkolopoulou, and Nikolaos Kavantzas

Subjects
Adenoma, Adult, Male, Oncology, medicine.medical_specialty, Topoisomerase iiα, ATP Binding Cassette Transporter, Subfamily B, Colorectal cancer, medicine.medical_treatment, Perineural invasion, Adenocarcinoma, Biology, Pathology and Forensic Medicine, Immunoenzyme Techniques, Antigens, Neoplasm, Internal medicine, Multidrug Resistance Proteins, Biomarkers, Tumor, medicine, Humans, Neoplasm Invasiveness, Stage (cooking), Aged, P-glycoprotein, Chemotherapy, Middle Aged, medicine.disease, Drug Resistance, Multiple, DNA-Binding Proteins, DNA Topoisomerases, Type II, Lymphatic Metastasis, Colonic Neoplasms, biology.protein, Immunohistochemistry, Female, Lymph Nodes, Multidrug Resistance-Associated Proteins
Abstract

Summary Aims To investigate the role of multidrug resistance proteins and topoisomerase II α in colon cancer. Methods Tissue sections from 89 Dukes' stage B–D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIα in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients. Results P-glycoprotein was associated with the presence of lymph node metastasis ( P =0.005), vessel invasion ( P =0.0001) and perineural invasion ( P =0.020). Conclusions P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination.

Published
2003

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