Search

Understanding the coordination of cell division timing is one of the outstanding questions in the field of developmental biology. One active control parameter of the cell cycle duration is temperature, as it can accelerate or decelerate the rate of biochemical reactions. However, controlled experiments at the cellular-scale are challenging due to the limited availability of biocompatible temperature sensors as well as the lack of practical methods to systematically control local temperatures and cellular dynamics. Here, we demonstrate a method to probe and control the cell division timing in Caenorhabditis elegans embryos using a combination of local laser heating and nanoscale thermometry. Local infrared laser illumination produces a temperature gradient across the embryo, which is precisely measured by in-vivo nanoscale thermometry using quantum defects in nanodiamonds. These techniques enable selective, controlled acceleration of the cell divisions, even enabling an inversion of division order at the two cell stage. Our data suggest that the cell cycle timing asynchrony of the early embryonic development in C. elegans is determined independently by individual cells rather than via cell-to-cell communication. Our method can be used to control the development of multicellular organisms and to provide insights into the regulation of cell division timings as a consequence of local perturbations., 6+6 pages, 4+9 figures

Photons are excellent information carriers but normally pass through each other without consequence. Engineered interactions between photons would enable applications from quantum information processing to simulation of condensed matter systems. Using an ensemble of cold atoms strongly coupled to an optical cavity, we demonstrate experimentally that the transmission of light through a medium may be controlled with few photons and even by the electromagnetic vacuum field. The vacuum induces a group delay of 25 ns on the input optical pulse, corresponding to a light velocity of 1600 m/s, and a transparency of 40% that increases to 80% when the resonator is filled with 10 photons. This strongly nonlinear effect provides prospects for advanced quantum devices such as photon-number-state filters., Comment: 13 pages, 4 figures

Understanding quantum dynamics away from equilibrium is an outstanding challenge in the modern physical sciences. It is well known that out-of-equilibrium systems can display a rich array of phenomena, ranging from self-organized synchronization to dynamical phase transitions. More recently, advances in the controlled manipulation of isolated many-body systems have enabled detailed studies of non-equilibrium phases in strongly interacting quantum matter. As a particularly striking example, the interplay of periodic driving, disorder, and strong interactions has recently been predicted to result in exotic "time-crystalline" phases, which spontaneously break the discrete time-translation symmetry of the underlying drive. Here, we report the experimental observation of such discrete time-crystalline order in a driven, disordered ensemble of $\sim 10^6$ dipolar spin impurities in diamond at room-temperature. We observe long-lived temporal correlations at integer multiples of the fundamental driving period, experimentally identify the phase boundary and find that the temporal order is protected by strong interactions; this order is remarkably stable against perturbations, even in the presence of slow thermalization. Our work opens the door to exploring dynamical phases of matter and controlling interacting, disordered many-body systems., Comment: 6 + 3 pages, 4 figures

Insights into complex phenomena in quantum matter can be gained from simulation experiments with ultracold atoms, especially in cases where theoretical characterization is challenging. However these experiments are mostly limited to short-range collisional interactions. Recently observed perturbative effects of long-range interactions were too weak to reach novel quantum phases. Here we experimentally realize a bosonic lattice model with competing short- and infinite-range interactions, and observe the appearance of four distinct phases - a superfluid, a supersolid, a Mott insulator and a charge density wave. Our system is based on an atomic quantum gas trapped in an optical lattice inside a high finesse optical cavity. The strength of the short-ranged on-site interactions is controlled by means of the optical lattice depth. The infinite-range interaction potential is mediated by a vacuum mode of the cavity and is independently controlled by tuning the cavity resonance. When probing the phase transition between the Mott insulator and the charge density wave in real-time, we discovered a behaviour characteristic of a first order phase transition. Our measurements have accessed a regime for quantum simulation of many-body systems, where the physics is determined by the intricate competition between two different types of interactions and the zero point motion of the particles., 11 pages, 11 figures

The dynamic structure factor is a central quantity describing the physics of quantum many-body systems, capturing structure and collective excitations of a material. In condensed matter, it can be measured via inelastic neutron scattering, which is an energy-resolving probe for the density fluctuations. In ultracold atoms, a similar approach could so far not be applied because of the diluteness of the system. Here we report on a direct, real-time and nondestructive measurement of the dynamic structure factor of a quantum gas exhibiting cavity-mediated long-range interactions. The technique relies on inelastic scattering of photons, stimulated by the enhanced vacuum field inside a high finesse optical cavity. We extract the density fluctuations, their energy and lifetime while the system undergoes a structural phase transition. We observe an occupation of the relevant quasi-particle mode on the level of a few excitations, and provide a theoretical description of this dissipative quantum many-body system., Nature Communications, 6, ISSN:2041-1723

We experimentally study the influence of dissipation on the driven Dicke quantum phase transition, realized by coupling external degrees of freedom of a Bose-Einstein condensate to the light field of a high-finesse optical cavity. The cavity provides a natural dissipation channel, which gives rise to vacuum-induced fluctuations and allows us to observe density fluctuations of the gas in real-time. We monitor the divergence of these fluctuations over two orders of magnitude while approaching the phase transition and observe a behavior which significantly deviates from that expected for a closed system. A correlation analysis of the fluctuations reveals the diverging time scale of the atomic dynamics and allows us to extract a damping rate for the external degree of freedom of the atoms. We find good agreement with our theoretical model including both dissipation via the cavity field and via the atomic field. Utilizing a dissipation channel to non-destructively gain information about a quantum many-body system provides a unique path to study the physics of driven-dissipative systems., 13 pages, 6 figures, including supplementary information

Long-range interactions in quantum gases are predicted to give rise to an excitation spectrum of roton character, similar to that observed in superfluid helium. We investigate the excitation spectrum of a Bose-Einstein condensate with cavity-mediated long-range interactions, which couple all particles to each other. Increasing the strength of the interaction leads to a softening of an excitation mode at a finite momentum, preceding a superfluid to supersolid phase transition. We study the mode softening spectroscopically across the phase transition using a variant of Bragg spectroscopy. The measured spectrum is in very good agreement with ab initio calculations and, at the phase transition, a diverging susceptibility is observed. The work paves the way towards quantum simulation of long-range interacting many-body systems., 10 pages, 5 figures, supplementary materials