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Introduction: The term Chemsex stands for the intentional use of certain psychoactive drugs to enhance sexual relations between gay, bisexual and other men who have sex with men (MSM), usually for long periods of time. Slamming or slamsex defines when drugs are injected intravenously in this context. It has been described psychopathological symptoms in chemsex context, like depression, anxiety or psychosis. "Sex, drugs and You" was created in the ONG Apoyo Positivo in Madrid, in order to offer a multidisciplinary approach to people who practice chemsex. Objectives: To describe the program and the profile and psychopathology of patients attended in the program "Sex, Drugs and You" from 2017 to 2018. Methods: Description of program and the profile and psychopathology of patients attended in the program "Sex, Drugs and You". Results: 138 patients were attended. Median age was 37,46 years. 40% engaged on slamsex and 79,2% were HIV positive. 62 (46,26%) were derived to psychiatric assesment. From these, 100% had a drug-abuse disorder, being the main drugs abused: mephedrone (69,3%), GHB(48,3%), Crystal Meth (32,2%), cocaine(19,3%) and ketamine (4.8%). 54,8% also abused poppers and 35,4% abused erectile disfunction drugs. From this subsample, 82,25% also had a comorbid psychopathological disorder: 30,6% depression, 22,5 % psychosis, 8% anxiety, 8% personality disorders, 4,8% ADHD and 1,6% OCD. Conclusions: The program "Sex, Drugs and You" offers a multidisciplinary approach for people that engage in chemsex. Our sample shows a high prevalence of drug-abuse disorders and other comorbid psychopathology. The role of the psychiatrist to treat disorders related to chemsex is essential. [ABSTRACT FROM AUTHOR]

Introduction: The intentional use of drugs before or during sexual intercourse (chemsex), due to its impact on mental health, is a phenomenon of high importance in men who have sex with men. Objectives: We report the case of a patient with polysubstance acute intoxication, including 2C-B, in order to review the evidence about the mechanisms of action of 2C-B, its efects on sexual pleasure, toxicity, patterns of abuse and somatic and mental health related consequences it may present. Methods: Case report and narrative review. Results: Wepresent the case of a patient using 2C-B as a substance in chemsex practice. As the patient presented in our emergency with psychotic symptoms, he was diagnosed with "stimulant acute intoxication" and "acute psychotic symptoms induced by stimulants". 2C-B increases dopamine (DA) serotonin (5-HT) and norepinephrine (NE) and cause stimulating and hallucinogenic effects. Conclusions: MSM is a group vulnerable to the problematic use of drugs in a sexual context. Several mental health problems have been associated with chemsex users such as psychotic sypmptoms, suicidal ideation, encephalopaty, delirium. Polysubstance use is common in chemsex practice and it can be difficult to identify the drugs used in states of acute intoxication but psychiatrists must explore the use of differents drugs from the "classic chemsex drugs" (mephedrone, GHB and metanphetamine) including 2C-B and other substances such as cocaine, MDMA, ketamine, and other cathinones different from mephedrone. [ABSTRACT FROM AUTHOR]

Introduction: The intentional use of drugs before or during sexual intercourse (chemsex), due to its impact on mental health, is a phenomenon of high importance in men who have sex with men. The main drugs usually described in chemsex related research are methamphetamine, mephedrone and GHB/GBL. Objectives: We present a narrative review of the evidence about the mechanisms of action of different drugs used in chemsex context. Methods: Narrative Review. Results: Different drugs have been associated with chemsex use: stimulants such as cocaine, stimulants with empathogenic properties such as mephedrone, methamphetamine,MDMA; stimulants with a psychedelic effect such as 2C-B; depressants such as GHB/GBL and ethyl chloride; and dissociative hallucinogens such as ketamine. Conclusions: Classical chemsex research includes only mephedrone, metanphetamine and GHB as "chemsex drugs". Recently, different drugs have been described associated with chemsex practice. Clinicians may encounter polydrug chemsex users and the different mecanisms of action, mental health problems related to every drug and polydrug use must be takek into account. [ABSTRACT FROM AUTHOR]

Introduction: Intentional use of psychoactive substances before or during sexual intercourse (chemsex) to increase both sexual pleasure and arousal is a phenomenon of special importance in the GBMSM (gay, bissexual and other men who have sex with men) population due to its impact on mental and physical health. Objectives: We report the case of a patient with a suicide attempt diagnosed with a mephedrone and GHB use disorder and a depressive disorder in chemsex context. To review the evidence on associations between chemsex and mental disorders. Methods: A case reported is presented. A narrative review was performed to analyze the association between chemsex practice and mental health disorders. Results: In qualitative research conducted in Europe with participants with chemsex practices, psychiatric symptoms in the context of acute consumption such as irritability, anxiety, aggressive behaviours where described. Memory loss and changes in personality and dependence substance disorders were described as longer-term psychiatric harms. Drug-induced psychosis, encephalopaty, serotonin syndrome and delirium were described in case reports. In quantitative research analyzing data from a 2014 survey of people attending HIV clinics, chemsex was associated with depression/anxiety, and use of other recreational drugs. Conclusions: There is a lack of robust evidence in the association of chemsex with mental health disorders. Research on the impact of chemsex on mental health is essential. Due to the high prevalence of mental disorders in MSM population and the possible harms from drug use, a collaborative approach (including mental and sexual health professionals) could be beneficial with the problems associated with chemsex. [ABSTRACT FROM AUTHOR]

Introduction: The intentional use of drugs before or during sexual intercourse (chemsex) is a phenomenon of special importance in the MSM (men who have sex with men) population due to its impact on mental, physical and sexual health. Mental health disorders such as psychosis, delirium and serotonine syndrome has been described associated with chemsex practices. Other sexual health issues such as difficulties in achieving sober sex or erectile dysfunction has been described. To date, no specific sexual health intervention has been described. Objectives: To describe a sexual health intervention program for patients with chemsex practices. We describe the profile of users according to socio-demographic, medical, psychopathological and drug-related characteristics. On the other hand, we analyze a survey of satisfaction made by users. Methods: Description of the program. Demographics, consumption patterns, other accompanying substances, use of geo-social applications and comorbid medical and psychiatric disease and perceived satisfaction data were described through a online survey. Results: 12 sexual health workshops were done based on behavioralcognitive theory, biopsychosocial and Sex Positive Model. The most common profile was a male of Spanish nationality, 35-45 years old, living with HIV and drug use perceived as problematic. 35% presented a reduction in frequency or amount of drug use. 10% stopped practicing chemsex. 45% presented a reduction in sexual risk behaviour. 60%perceived an improvement in perceived social support and increased awareness of presenting a drug addiction. Conclusions: Interventions in sexual health were perceived as satisfactory and useful by users to improve their sexual health and self-efficacy to change substance use patterns. [ABSTRACT FROM AUTHOR]