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Brain MRI voxel based morphometry (VBM) is known as a research tool for neurodegenerative and psychiatric disorders. The aim of this study was to evaluate a possible association of cortical thickness, cortical and subcortical volume in PD pa-tients.with neuropsychiatric disturbancies after deep brain stimulation, sleep impairment and quality of life. Methods. Twenty-eight PD patients (14 men and 14 women, median age 58 years) were evaluated for sleep disturbances with PDSS, quality of life with PDQ-39, SF-36 and underwent brain MRI. Twenty-two of these patients underwent STN-DBS and observed for neuropsychiatric complications after STN-DBS implantation surgery. Control group consisted of 28 healthy volunteers who were matched by age and gender. Automated voxel based image analysis was performed with the FreeSurfer software. Results. PD patients with nocturnal hallucinations had prominent basal ganglia volume reduction. Distressful dreams were associated with limbic system and frontal white matter changes. Volumetric analysis showed significant differences in cortical thickness between STN-DBS patients with and without postoperative neuropsychiatric complications in 13 gyruses on the right hemisphere and in 7 gyruses on the left hemisphere. White matter volume analysis showed also its reduction in the left caudal middle frontal area. Foundings suggest that neuropsychiatric complications after DBS can be associated with excitation of frontal-striatum-thalamus and temporal-parietal circuits. Decreased social functioning in PD patients can be associated with white matter reduction in cingulate area. Conclusions. Neuropsychiatric complications after DBS can be associated with excitation offrontal-striatum-thalamusand temporal-parietal circuits. PD patients with nocturnal hallucinations had prominent basal ganglia volume reduction [ABSTRACT FROM AUTHOR]