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Abstract: The Leksell Gamma Knife is a stereotactic radio-surgery unit for the treatment of small volumes (on the order of 25mm3) that employs a hemispherical configuration of 201 60Co sources and appropriate configurations of collimation to form beams of 4, 8, 14 and 18mm nominal diameter at the Unit Center Point (UCP). Although Monte Carlo (MC) simulation is well suited for narrow-beam dosimetry, experimental dosimetry is required at least for acceptance testing and quality assurance purposes. Besides other drawbacks of conventional point dosimeters, the main problems associated with narrow-beam dosimetry in stereotactic applications are accurate positioning and volume averaging. In this work, MCNPX and EGSnrc MC simulation dosimetry results for a Gamma Knife unit are benchmarked through their comparison to treatment planning software calculations based on radio-chromic film measurements. Then, MC dosimetry results are utilized to optimize the only three-dimensional experimental dosimetry method available; the polymer gel-Magnetic Resonance Imaging (MRI) method. MC results are used to select the spatial resolution in the imaging session of the irradiated gels and validate a mathematical tool for the localization of the UCP in the three-dimensional experimental dosimetry data acquired. Experimental results are compared with corresponding MC calculations and shown capable to provide accurate dosimetry, free of volume averaging and positioning uncertainties. [Copyright &y& Elsevier]