18 results on '"Carcinoma, Verrucous therapy"'
Search Results
2. Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: A literature review and analysis.
- Author
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Akrish S, Eskander-Hashoul L, Rachmiel A, and Ben-Izhak O
- Subjects
- Carcinoma, Verrucous mortality, Carcinoma, Verrucous secondary, Carcinoma, Verrucous therapy, Disease Progression, Female, Humans, Hyperplasia, Leukoplakia, Oral mortality, Leukoplakia, Oral secondary, Leukoplakia, Oral therapy, Lymphatic Metastasis, Male, Middle Aged, Mouth Neoplasms mortality, Mouth Neoplasms therapy, Neoplasm Invasiveness, Precancerous Conditions mortality, Precancerous Conditions therapy, Prognosis, Squamous Cell Carcinoma of Head and Neck mortality, Squamous Cell Carcinoma of Head and Neck secondary, Squamous Cell Carcinoma of Head and Neck therapy, Carcinoma, Verrucous pathology, Cell Proliferation, Leukoplakia, Oral pathology, Mouth Neoplasms pathology, Precancerous Conditions pathology, Squamous Cell Carcinoma of Head and Neck pathology
- Abstract
Objective: Proliferative verrucous leukoplakia is classified as a potentially malignant disorder because of its high rate of malignant transformation. PVL progresses in a series of clinical stages where the early stage represents multiple, multifocal leukoplakias with a high recurrence rate. The intermediate and late stages are clinically exophytic lesion, diagnosed microscopically as verrucous hyperplasia that often progresses into verrucous carcinoma and/or squamous cell carcinoma. There is no single histologic definition and the diagnosis is retrospective following observed progression of the disorder. The goal of the current study was to conduct a literature review and analysis of PVL in the later stages to gain further knowledge on their clinicopathologic features., Data Sources: Medline's PubMed and Google Scholar were searched for adequately documented cases from 1985 to 2018. References of published articles were searched for additional cases., Review Methods: Overall, 57 manuscripts were analyzed. 35/57 manuscripts provided adequate data on the clinicopathologic features in the premalignant and malignant stages., Results: Malignant transformation rate was 50% (average of 57 months). Gingiva, palate and buccal mucosa were the most common locations. Clinicopathologic features included; well differentiated carcinoma (78%), perineural invasion (3%), lymph node metastasis (4%); distant metastasis (0%), average duration of illness (65 months), DOD-dead of disease (44%). Moderate dysplasia, severe dysplasia and carcinoma in situ were exceptionally uncommon in the premalignant stages (0.8%)., Conclusion: Prognostic factors such as perineural invasion, lymph node metastasis and distant metastasis were uncommon occurrences which may have practical implications on treatment. Further studies are needed to substantiate our findings., (Copyright © 2019 Elsevier GmbH. All rights reserved.)
- Published
- 2019
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3. [Precancerous lesions of the buccal epithelium].
- Author
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Renaud-Vilmer C and Cavelier-Balloy B
- Subjects
- Carcinoma in Situ diagnosis, Carcinoma in Situ epidemiology, Carcinoma in Situ pathology, Carcinoma in Situ therapy, Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell therapy, Carcinoma, Verrucous diagnosis, Carcinoma, Verrucous epidemiology, Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, Cross-Sectional Studies, Delayed Diagnosis, Erythroplasia diagnosis, Erythroplasia epidemiology, Erythroplasia pathology, Erythroplasia therapy, Humans, Leukoplakia, Oral diagnosis, Leukoplakia, Oral epidemiology, Leukoplakia, Oral pathology, Leukoplakia, Oral therapy, Lip pathology, Lip Neoplasms epidemiology, Lip Neoplasms therapy, Mouth Mucosa pathology, Mouth Neoplasms epidemiology, Mouth Neoplasms therapy, Precancerous Conditions epidemiology, Precancerous Conditions therapy, Prognosis, Risk Factors, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell pathology, Lip Neoplasms diagnosis, Lip Neoplasms pathology, Mouth Neoplasms diagnosis, Mouth Neoplasms pathology, Precancerous Conditions diagnosis, Precancerous Conditions pathology
- Abstract
Squamous cell carcinomas of the oral cavity and lips consistently have a high incidence (they constitute the fifth most common form of cancer in France) and carry a heavy prognosis, particularly if diagnosed late. According to different studies, between 10 and 80% of such carcinomas occur in a pre-existing or precancerous lesion. The World Health Organisation (WHO) recommends the use of two terms for such lesions: precursor lesions, i.e. histological lesions associated with intraepithelial neoplasia (IEN) and verrucous hyperplasia (VH), frequently resulting clinically in leukoplakia or erythroplakia; "at risk" lesions, which include lichen planus, submucosal oral fibrosis and certain forms of genodermatosis., (Copyright © 2016. Published by Elsevier Masson SAS.)
- Published
- 2017
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4. Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review).
- Author
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Peng Q, Wang Y, Quan H, Li Y, and Tang Z
- Subjects
- Carcinoma, Verrucous diagnosis, Carcinoma, Verrucous genetics, Carcinoma, Verrucous therapy, Humans, Mouth Mucosa pathology, Mouth Neoplasms diagnosis, Mouth Neoplasms genetics, Mouth Neoplasms therapy, Biomarkers, Tumor genetics, Carcinoma, Verrucous pathology, Mouth Neoplasms pathology
- Abstract
Oral verrucous carcinoma (OVC) is a verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2-12% of all oral carcinomas with a 5-year survival rate of only approximately 50%. Enormous effort has been dedicated to this cancer, and the past decades have witnessed significant advances in relevant diagnostic and therapeutic approaches. Currently, there exist three challenges from primary sub-fields of research and clinical practice of the cancer, namely multifactorial etiology, complex molecular mechanism, and deficient treatment. This study reviews the existing literature on the cancer, encompassing its etiology, clinical manifestations and pathology, molecular mechanism, diagnosis and differential diagnosis, and treatment. For improved treatment of OVC, multifactorial etiology analysis, incorporation of effective biomarkers for mechanism illustration, and integration of multidisciplinary modalities are expounded, in an attempt to resolve the challenges and to provide a useful guide for future research in the field.
- Published
- 2016
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5. Oral verrucous carcinoma complicating a repetitive injury by the dental prosthesis: a case report.
- Author
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Rahali L, Omor Y, Mouden K, Mahdi Y, Elkacemi H, Elmajjaoui S, Latib R, Kebdani T, Boujida MN, and Benjaafar N
- Subjects
- Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, Female, Humans, Middle Aged, Mouth Neoplasms pathology, Mouth Neoplasms therapy, Carcinoma, Verrucous etiology, Dental Prosthesis adverse effects, Mouth Neoplasms etiology
- Abstract
Verrucous carcinoma (VC) is an unusual, well differentiated, and low-grade type of squamous cell carcinoma, characterized by benign histology and cytology but markedly invasive clinical behavior. They have a predilection for squamous mucosae, particularly those of the head and neck region. Many factors have been associated with its pathogenesis, including the presence of previous skin lesions; VC arising from a prosthesis injury is rare. Here we reported a case of VC of oral cavity a particularly very aggressive, arising from prosthesis injury. Regardless of the treatment modality, given new insights into the possible aggressivity of this tumor, radiotherapy associated to chemotherapy may be a more appropriate primary treatment compared with the significant local morbidity associated with surgery.
- Published
- 2015
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6. Oral squamous cell carcinoma associated with proliferative verrucous leukoplakia compared with conventional squamous cell carcinoma--a clinical, histologic and immunohistochemical study.
- Author
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Akrish S, Ben-Izhak O, Sabo E, and Rachmiel A
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell therapy, Carcinoma, Verrucous therapy, Female, Humans, Immunoenzyme Techniques, Leukoplakia, Oral therapy, Male, Middle Aged, Mouth Neoplasms therapy, Neoplasm Staging, Retrospective Studies, Survival Rate, Carcinoma, Squamous Cell pathology, Carcinoma, Verrucous pathology, Leukoplakia, Oral pathology, Mouth Neoplasms pathology
- Abstract
Objective: Proliferative verrucous leukoplakia (PVL), a potentially malignant disorder, often undergoes malignant transformation to oral squamous cell carcinoma. The aim of our study was to document and compare the histologic, immunohistochemical, and clinical features and the survival rates of carcinoma arising in patients with PVL (p-scca) with conventional squamous cell carcinoma (c-scca) in order to determine if p-scca should be categorized as a separate clinical entity., Materials and Methods: A retrospective review of 11 patients with PVL, 38 with p-scca tumors and 49 with c-scca tumors: buccal mucosa (n = 28) and gingiva or palate (n = 21). Immunohistochemistry was performed by using antibodies directed against p16, p53, and ki67., Results: P-scca had lower clinical stage (P = .0001), smaller tumor size (P = .0033), no lymph node metastasis (P = .0002) or distant metastasis (P = .05), and better short term (P = .03), but not long term (P = .12) survival. Microscopically, p-scca tumor thickness was significantly less (P = .0001). P-53 overexpression was more common in p-scca (P = .0043) but not ki67 or p16 overexpression., Conclusions: P-scca, compared with c-scca, presented with significantly better prognostic factors and short-term survival rates and longer duration of disease. Our results suggest that p-scca may represent a distinct entity, which may have practical implications when deciding on treatment. Further studies on a larger cohort of patients are recommended., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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7. Proliferative verrucous leukoplakia: recognition and differentiation from conventional leukoplakia and mimics.
- Author
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Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, and El-Naggar AK
- Subjects
- Aged, Biopsy, Needle, Carcinoma, Verrucous physiopathology, Carcinoma, Verrucous therapy, Diagnosis, Differential, Disease Progression, Early Diagnosis, Female, Humans, Immunohistochemistry, Leukoplakia, Oral physiopathology, Leukoplakia, Oral therapy, Male, Middle Aged, Mouth Neoplasms physiopathology, Mouth Neoplasms therapy, Carcinoma, Verrucous pathology, Cell Transformation, Neoplastic pathology, Leukoplakia, Oral pathology, Mouth Neoplasms pathology, Precancerous Conditions parasitology
- Abstract
The majority of conventional leukoplakia remains constant and only a subset progress to high-grade dysplasia or invasive carcinoma. A less recognized form known as proliferative verrucous leukoplakia (PVL) represents a unique progressive and elusive variant. Identifying patients with this form can only be achieved through the keen clinical observation of the temporal gross and histologic progression in individual patients with squamous cell carcinoma. The difficulty in the early diagnosis of PVL stems from the overlapping clinical and pathologic features with conventional multifocal leukoplakia with dysplasia. We present the current view on the clinicopathologic and biological characteristics of PVL and discuss their diagnosis, differential diagnosis, and management., (© 2014 Wiley Periodicals, Inc.)
- Published
- 2014
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8. Successful treatment of oral verrucous hyperplasia with photodynamic therapy combined with cryotherapy--report of 3 cases.
- Author
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Chang YC and Yu CH
- Subjects
- Adult, Combined Modality Therapy, Humans, Male, Middle Aged, Photosensitizing Agents therapeutic use, Treatment Outcome, Aminolevulinic Acid therapeutic use, Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, Cryotherapy methods, Mouth Neoplasms pathology, Mouth Neoplasms therapy
- Abstract
Our previous study showed successful treatment of a large oral verrucous hyperplasia (OVH) with topical 5-aminolevulinic acid-mediated photodynamic therapy combined with cryotherapy (ALA-PDT). In this case series, we extended this combined method for another three OVH lesions in three different patients. The clinical procedure was conducted as follows: the OVH lesions were irradiated with a 635-nm laser 1.5h after topical application of 20% ALA on the lesion for a total of 1000 s, which consisted of five 3-min and one 100-s irradiations separated by five 3-min rests. Cryogun cryotherapy was then performed on the lesion after ALA-PDT. The tumor was cleared after 1-6 treatments. No recurrence of the lesion was found after a follow-up period of 6-24 months. We suggest that our combined treatment protocol may be effective in treating OVH lesions., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2014
- Full Text
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9. Idiopathic proliferative verrucous leukoplakia: report of a clinical rarity.
- Author
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Singh AP, Chaitra TR, Kulkarni AU, and Jathar PN
- Subjects
- Carcinoma, Verrucous therapy, Cell Transformation, Neoplastic, Follow-Up Studies, Humans, Leukoplakia, Oral therapy, Male, Middle Aged, Mouth Neoplasms prevention & control, Carcinoma, Verrucous pathology, Leukoplakia, Oral pathology, Mouth Mucosa pathology, Mouth Neoplasms pathology, Precancerous Conditions pathology
- Published
- 2012
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10. Oral verrucous carcinoma treated with imiquimod 5% cream and carbon dioxide laser.
- Author
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Cecchi R, Bartoli L, Brunetti L, and Pavesi M
- Subjects
- Aged, 80 and over, Combined Modality Therapy, Humans, Imiquimod, Male, Aminoquinolines therapeutic use, Antineoplastic Agents therapeutic use, Carcinoma, Verrucous therapy, Lasers, Gas therapeutic use, Mouth Neoplasms therapy
- Published
- 2011
- Full Text
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11. Oral verrucous hyperplasia: histologic classification, prognosis, and clinical implications.
- Author
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Wang YP, Chen HM, Kuo RC, Yu CH, Sun A, Liu BY, Kuo YS, and Chiang CP
- Subjects
- Adult, Age Distribution, Aged, Aged, 80 and over, Areca adverse effects, Carcinoma, Squamous Cell etiology, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Carcinoma, Verrucous etiology, Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, Cell Transformation, Neoplastic classification, Female, Humans, Hyperplasia classification, Hyperplasia etiology, Hyperplasia pathology, Leukoplakia, Oral classification, Leukoplakia, Oral complications, Leukoplakia, Oral pathology, Male, Middle Aged, Mouth Diseases classification, Mouth Diseases complications, Mouth Mucosa pathology, Mouth Neoplasms etiology, Mouth Neoplasms therapy, Precancerous Conditions etiology, Precancerous Conditions therapy, Smoking adverse effects, Warts classification, Young Adult, Cell Transformation, Neoplastic pathology, Mouth Diseases pathology, Mouth Neoplasms pathology, Precancerous Conditions pathology, Warts pathology
- Abstract
Background: Oral verrucous hyperplasia (OVH) is a premalignant lesion that may transform into an oral cancer., Methods: Sixty consecutive OVH cases were collected from 2003 to 2004. Clinicopathological features and the 5-year malignant transformation rate of these 60 OVH lesions were evaluated and analyzed., Results: We found that 84% of OVH lesions occurred in patients between 40 and 69 years of age. The most common site for OVH lesions was the buccal mucosa (48%), followed by the tongue (20%), palate (18%), gingiva (7%), and labial mucosa (7%). Approximately 91% of OVH patients were areca quid chewers and 89% were smokers. When 60 OVH lesions were classified into 30 plaque-typed and 30 mass-typed OVH lesions, the mass-typed OVH lesions had a higher malignant transformation rate of 17% (5/30) than the plaque-typed OVH lesions (3%, 1/30) during a mean follow-up period of 59 +/- 7 months. The mean time for malignant transformation was 22 +/- 11 months. Of the 6 OVH lesions with malignant transformation, 2 underwent total surgical excision and 4 did not receive any form of therapy., Conclusions: We conclude that OVH lesions occur more commonly on the buccal mucosa and are highly associated with the areca quid chewing and cigarette smoking habits. The overall 5-year malignant transformation rate of 60 OVH lesions was 10%. The mass-typed OVH lesions had a higher malignant transformation rate than the plaque-typed OVH lesions and thus should receive an immediate treatment, such as total surgical excision or photodynamic therapy, after the histopathologic diagnosis.
- Published
- 2009
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12. Verrucous oral carcinoma: clinical findings and treatment outcomes in 74 patients in Northwest Italy.
- Author
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Arduino PG, Carrozzo M, Pagano M, Gandolfo S, and Broccoletti R
- Subjects
- Aged, Carcinoma, Verrucous mortality, Female, Humans, Italy, Male, Middle Aged, Mouth Neoplasms mortality, Survival Rate, Carcinoma, Verrucous therapy, Mouth Neoplasms therapy
- Abstract
Aim: Oral squamous cell carcinoma (OSCC) is an extremely invasive tumour of stratified squamous epithelium that spreads throughout degradation of the basement membrane (BM) and extracellular matrix (ECM). Oral verrucous carcinoma (VC) is a rare low-grade variant of OSCC. VC has a different clinical behaviour from classical OSCC and the optimal treatment is controversial. This report analyses the clinical features and outcomes in patients undergoing treatment for oral VC., Methods: A group of 74 Northern Italian patients were studied; for each patient, agreement of histological diagnosis, age and gender, risk factors, tumor site, T classification, treatment, outcome and survival rate were examined and analysed statistically., Results: The survival rate was 93.65% at 5 years and 83.44% at 10 years. Retrospective analysis showed no risk of cervical lymph node metastasis and surgical treatment results were good., Conclusion: Our survival rates showed a good prognosis, with no risk of cervical lymph node metastases, suggesting that most cases can be controlled by surgery alone.
- Published
- 2008
13. Treatment results of oral verrucous carcinoma and its biological behavior.
- Author
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Ogawa A, Fukuta Y, Nakajima T, Kanno SM, Obara A, Nakamura K, Mizuki H, Takeda Y, and Satoh M
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Verrucous metabolism, Carcinoma, Verrucous surgery, Combined Modality Therapy methods, Female, Humans, Hyaluronan Receptors analysis, Immunohistochemistry methods, Male, Middle Aged, Mouth Neoplasms metabolism, Mouth Neoplasms surgery, Proliferating Cell Nuclear Antigen analysis, Treatment Outcome, Tumor Suppressor Protein p53 analysis, Carcinoma, Verrucous therapy, Mouth Neoplasms therapy
- Abstract
The biologic behavior of and optimal treatment for oral verrucous carcinoma (VC) remain controversial. We analyzed the clinicopathological characteristics of 12 patients with oral VC. Immunohistochemical techniques were used to evaluate p53 protein, CD44 variant 9, and proliferating cell nucleus antigen. The TNM classification (UICC, 1997) was T1 in 1 patient, T2 in 3, T3 in 4, and T4 in 4. All patients were classified as N0M0. Four patients were treated by surgery alone and 8 by surgery after chemotherapy, radiotherapy, or both. After surgery, two patients had primary recurrence of disease. Immunohistochemically, the proliferative activity of tumor cells as evaluated by proliferating cell nuclear antigen labeling index and p53 protein expression was similar in VC and well-differentiated squamous cell carcinoma. However, CD44 varient 9 expression was positive in 8 of 10 VC, suggesting that oral VC is associated with a low risk of lymph node metastasis. Positive CD44 variant 9 expression by most oral VCs, indicating a low risk of cervical lymph node metastasis, suggests that most cases can be controlled by surgical intervention.
- Published
- 2004
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14. Oral cancer. The importance of early diagnosis and treatment.
- Author
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Sciubba JJ
- Subjects
- Biopsy, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Carcinoma, Squamous Cell therapy, Carcinoma, Verrucous diagnosis, Carcinoma, Verrucous pathology, Carcinoma, Verrucous surgery, Carcinoma, Verrucous therapy, Combined Modality Therapy, Diagnosis, Differential, Humans, Leukoplakia, Oral diagnosis, Leukoplakia, Oral pathology, Leukoplakia, Oral surgery, Leukoplakia, Oral therapy, Neoplasm Staging, Palatal Neoplasms diagnosis, Palatal Neoplasms pathology, Palatal Neoplasms surgery, Palatal Neoplasms therapy, Palliative Care, Prognosis, Risk Factors, Time Factors, Tongue pathology, Tongue Neoplasms diagnosis, Tongue Neoplasms pathology, Tongue Neoplasms surgery, Tongue Neoplasms therapy, World Health Organization, Mouth Neoplasms diagnosis, Mouth Neoplasms etiology, Mouth Neoplasms pathology, Mouth Neoplasms surgery, Mouth Neoplasms therapy, Precancerous Conditions diagnosis, Precancerous Conditions pathology, Precancerous Conditions surgery, Precancerous Conditions therapy
- Abstract
Oral cancer is an important health issue. The WHO predicts a continuing worldwide increase in the number of patients with oral cancer, extending this trend well into the next several decades. In the US the projected number of new cases of oral and oropharyngeal cancer will exceed 31,000 per year. Mortality due to cancers in this region exceeds the annual death rate is the US caused by either cutaneous melanoma or cervical cancer. Significant agents involved in the etiology of oral cancer in Western countries include sunlight exposure, smoking and alcohol consumption. Use of the areca or betel nut in many cultures is a major etiological factor outside of the USA. Other etiologic factors associated with oral squamous cell carcinoma, but far less significant statistically, include syphilis and sideropenic dysphagia. Recently, strong evidence for an etiological relationship between human papilloma virus and a subset of head and neck cancers has been noted. It is generally accepted that most sporadic tumors are the result of a multi-step process of accumulated genetic alterations. These alterations affect epithelial cell behavior by way of loss of chromosomal heterozygosity which in turn leads to a series of events progressing to the ultimate stage of invasive squamous cell carcinoma. The corresponding genetic alterations are reflected in clinical and microscopic pathology from hyperplasia through invasiveness. A wide range of mucosal alternations fall within the rubric of leukoplakia. Proliferative verrucous leukoplakia represents a relatively new type of leukoplakia that is separate from the more common or less innocuous form of this condition. Erythroplakia is particularly relevant considering its almost certain relationship with dysplasia or invasive carcinoma. Squamous cell carcinoma will develop from antecedent dysplastic oral mucosal lesions if an early diagnosis has not been made and treatment given. Early diagnosis within stages I and II correspond to a vastly improved 5-year survival rate when compared with more advanced stage III and IV lesions. Surgical management of this disease remains the mainstay of treatment. Other therapies include radiation and chemotherapy options that may be used adjunctively and palliatively. Following treatment, it is important to understand the significant risks of second primary cancers developing within the upper aerodigestive tract as a result of field cancerization. The most important message is that early detection of the asymptomatic early stage oral cancer translates in general terms to satisfactory clinical outcome and cure in most patients.
- Published
- 2001
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15. HPV-11- and HPV-16-associated oral verrucous carcinoma.
- Author
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Lübbe J, Kormann A, Adams V, Hassam S, Grätz KW, Panizzon RG, and Burg G
- Subjects
- Aged, Aged, 80 and over, Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, DNA, Viral analysis, Fatal Outcome, Humans, Male, Mouth Mucosa pathology, Mouth Mucosa virology, Mouth Neoplasms pathology, Mouth Neoplasms therapy, Papillomavirus Infections pathology, Papillomavirus Infections therapy, Polymerase Chain Reaction, Tumor Virus Infections pathology, Tumor Virus Infections therapy, Carcinoma, Verrucous virology, Mouth Neoplasms virology, Papillomaviridae isolation & purification, Papillomavirus Infections complications, Tumor Virus Infections complications
- Abstract
Background: Verrucous carcinoma is a slowly growing, well-differentiated neoplasm with a predilection for the oral cavity., Objective: Data on the association of human papillomavirus (HPV) with oral verrucous carcinoma are very scarce. We searched for the presence of HPV in different stages of the tumour in a patient repeatedly treated by means of surgery, cryotherapy, radiotherapy and chemotherapy over a decade., Methods: HPV DNA was detected in archival tumour tissue by nested PCR. HPV types were identified based on restriction fragment analysis., Results: HPV type 11 was found in 1 early-stage and HPV 16 in 2 late-stage biopsy specimens of the tumour., Conclusion: Our findings provide further evidence for a role of HPV in oral verrucous carcinoma. The case history emphasizes the importance of a joint clinicopathological approach to this tumour.
- Published
- 1996
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16. Verrucous carcinoma of the mouth.
- Author
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Jordan RC
- Subjects
- Humans, Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, Carcinoma, Verrucous virology, Mouth Neoplasms pathology, Mouth Neoplasms therapy, Mouth Neoplasms virology
- Abstract
Verrucous carcinoma is a slow-growing, well differentiated carcinoma that is chiefly exophytic but can invade and destroy oral tissues. It typically presents as an extensive, white, warty lesion of the buccal mucosa or mandibular gingiva, although it also occurs at other sites. Diagnosis can be difficult, with repeat biopsies being needed in some cases. The persistent nature of the condition can make management difficult and the possibility of recurrent disease is high.
- Published
- 1995
17. Verrucous carcinoma of the oral cavity.
- Author
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Florin EH, Kolbusz RV, and Goldberg LH
- Subjects
- Humans, Prognosis, Recurrence, Carcinoma, Verrucous epidemiology, Carcinoma, Verrucous etiology, Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, Mouth Neoplasms epidemiology, Mouth Neoplasms etiology, Mouth Neoplasms pathology, Mouth Neoplasms therapy
- Published
- 1994
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18. Carcinoma of the oral cavity in patients over 75 years of age.
- Author
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Ehlinger P, Fossion E, and Vrielinck L
- Subjects
- Age Factors, Aged, Aged, 80 and over, Alcohol Drinking, Carcinoma, Adenoid Cystic mortality, Carcinoma, Adenoid Cystic pathology, Carcinoma, Adenoid Cystic therapy, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Carcinoma, Verrucous mortality, Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, Female, Humans, Male, Mouth Neoplasms therapy, Neoplasm Recurrence, Local, Neoplasm Staging, Retrospective Studies, Sex Ratio, Smoking, Surgical Flaps, Survival Rate, Treatment Outcome, Mouth Neoplasms mortality, Mouth Neoplasms pathology
- Abstract
The results have been analyzed of a 15-year retrospective study on the presentation and survival of 46 patients aged > or = 75 years with oral carcinoma. All tumors were staged according to the UICC criteria. The presence of other malignant tumors in nine, premalignancy in five, and systemic disease in 15 patients was noted. A large subpopulation of elderly women, nonusers of alcohol and tobacco, usually with advanced disease, was found. In one-quarter of the patients who underwent surgery, a major resection with primary flap reconstruction was judged to be necessary. In general, this type of surgery was well tolerated. Three-year survival was 60%; women, systemically compromised patients, and patients with stage III and IV tumors did worse. A recurrence ratio of 59% was found after 5 years, recurrence usually appearing during the first year. The conversion rate was low (8.5%).
- Published
- 1993
- Full Text
- View/download PDF
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