4 results on '"Broersen, Robin"'
Search Results
2. Cerebellar plasticity and associative memories are controlled by perineuronal nets.
- Author
-
Carulli, Daniela, Broersen, Robin, de Winter, Fred, Muir, Elizabeth M., Mešković, Maja, de Waal, Matthijs, de Vries, Sharon, Boele, Henk-Jan, Canto, Cathrin B., De Zeeuw, Chris I., and Verhaagen, Joost
- Subjects
- *
PERINEURONAL nets , *MOTOR learning , *EXTRACELLULAR matrix , *ASSOCIATIVE learning , *NEUROPLASTICITY - Abstract
Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are prominently expressed around neurons of the deep cerebellar nuclei (DCN), but their role in adult cerebellar plasticity and behavior is far from clear. Here we show that PNNs in the mouse DCN are diminished during eyeblink conditioning (EBC), a form of associative motor learning that depends on DCN plasticity. When memories are fully acquired, PNNs are restored. Enzymatic digestion of PNNs in the DCN improves EBC learning, but intact PNNs are necessary for memory retention. At the structural level, PNN removal induces significant synaptic rearrangements in vivo, resulting in increased inhibition of DCN baseline activity in awake behaving mice. Together, these results demonstrate that PNNs are critical players in the regulation of cerebellar circuitry and function. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
3. Early Trajectory Prediction in Elite Athletes.
- Author
-
Owens, Cullen B., de Boer, Casper, Gennari, Giulia, Broersen, Robin, Pel, Johan J., Miller, Brian, Clapp, Wesley, van der Werf, Ysbrand D., and De Zeeuw, Chris I.
- Subjects
ELITE athletes ,FEEDBACK control systems ,COGNITIVE ability ,MOTOR learning ,PREDICTION (Psychology) - Abstract
Cerebellar plasticity is a critical mechanism for optimal feedback control. While Purkinje cell activity of the oculomotor vermis predicts eye movement speed and direction, more lateral areas of the cerebellum may play a role in more complex tasks, including decision-making. It is still under question how this motor-cognitive functional dichotomy between medial and lateral areas of the cerebellum plays a role in optimal feedback control. Here we show that elite athletes subjected to a trajectory prediction, go/no-go task manifest superior subsecond trajectory prediction accompanied by optimal eye movements and changes in cognitive load dynamics. Moreover, while interacting with the cerebral cortex, both the medial and lateral cerebellar networks are prominently activated during the fast feedback stage of the task, regardless of whether or not a motor response was required for the correct response. Our results show that cortico-cerebellar interactions are widespread during dynamic feedback and that experience can result in superior task-specific decision skills. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
4. Cerebellar plasticity and associative memories are controlled by perineuronal nets
- Author
-
Henk-Jan Boele, Daniela Carulli, Fred de Winter, Maja Meškovic, Elizabeth M. Muir, Sharon de Vries, Matthijs de Waal, Cathrin B. Canto, Joost Verhaagen, Chris I. De Zeeuw, Robin Broersen, Carulli, Daniela [0000-0003-1365-7063], Broersen, Robin [0000-0003-2555-9719], Verhaagen, Joost [0000-0002-8341-1096], Apollo - University of Cambridge Repository, Netherlands Institute for Neuroscience (NIN), Molecular and Cellular Neurobiology, Amsterdam Neuroscience - Neurodegeneration, and Neurosciences
- Subjects
Male ,Cerebellum ,Plasticity ,Eyeblink conditioning ,Deep cerebellar nuclei ,Inbred C57BL ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Memory ,Neuroplasticity ,Learning ,Perineuronal net ,Animals ,Blinking ,Cerebellar Nuclei ,Conditioning, Eyelid ,Extracellular Matrix ,Mice, Inbred C57BL ,Nerve Net ,Neuronal Plasticity ,Neurons ,medicine ,otorhinolaryngologic diseases ,Associative property ,030304 developmental biology ,0303 health sciences ,Multidisciplinary ,Chemistry ,Biological Sciences ,Eyelid ,medicine.anatomical_structure ,Neuron ,Motor learning ,Neuroscience ,030217 neurology & neurosurgery ,Conditioning - Abstract
Significance Understanding mechanisms underlying learning and memory is crucial in view of tackling cognitive decline occurring during aging or following neurological disorders. The cerebellum offers an ideal system to achieve this goal because of the well-characterized forms of motor learning that it controls. It is so far unclear whether cerebellar memory processes depend on changes in perineuronal nets (PNNs). PNNs are assemblies of extracellular matrix molecules around neurons, which regulate neural plasticity. Here we demonstrate that during eyeblink conditioning (EBC), which is a form of cerebellar motor learning, PNNs in the mouse deep cerebellar nuclei are dynamically modulated, and PNN changes are essential for the formation and storage of EBC memories. Together, these results unveil an important mechanism controlling motor associative memories., Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are prominently expressed around neurons of the deep cerebellar nuclei (DCN), but their role in adult cerebellar plasticity and behavior is far from clear. Here we show that PNNs in the mouse DCN are diminished during eyeblink conditioning (EBC), a form of associative motor learning that depends on DCN plasticity. When memories are fully acquired, PNNs are restored. Enzymatic digestion of PNNs in the DCN improves EBC learning, but intact PNNs are necessary for memory retention. At the structural level, PNN removal induces significant synaptic rearrangements in vivo, resulting in increased inhibition of DCN baseline activity in awake behaving mice. Together, these results demonstrate that PNNs are critical players in the regulation of cerebellar circuitry and function.
- Published
- 2020
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.