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Background: Sophora moorcroftiana is an endemic shrub species with a great value in folk medicine in Tibet, China. In this study, relatively little is known about whether S. moorcroftiana is beneficial in animals' nervous system and life span or not. Materials and Methods: To address this question, under survival normal temperature (25°C), S. moorcroftiana seeds were extracted with 95% ethanol, and Caenorhabditis elegans were exposed to three different extract concentrations (100 mg/L, 200 mg/L, and 400 mg/mL) from S. moorcroftiana seeds. Results: The 95% ethanolic extracts from S. moorcroftiana seeds could increase life span and slow aging-related increase in C. elegans and could not obviously influence the motility of C. elegans . Conclusion: Given these results by our experiment for life span and motility with 95% ethanolic extracts from S. moorcroftiana seeds in C. elegans , the question whether S. moorcroftiana acts as an anti-aging substance in vivo arises. SUMMARY The 95% ethanolic extracts from S. moorcroftiana seeds have no effect on the life span in C. elegans when extract concentrations from S. moorcroftiana seeds The 400 mg/L 95% ethanolic extracts from S. moorcroftiana seeds could increase life span in C. elegans The 95% ethanolic extracts from S. moorcroftiana seeds could not obviously influence the motility in C. elegans . Abbreviation used: S. moorcroftiana: Sophora moorcroftiana ; C. elegan: Caenorhabditis elegan ; E. coli OP50: Escherichia coli OP50 ; DMSO: Dimethyl sulfoxide.