1. Body mass index and mortality in elderly men and women from general population. The experience of Cardiovascular Study in the Elderly (CASTEL).
- Author
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Mazza A, Zamboni S, Tikhonoff V, Schiavon L, Pessina AC, and Casiglia E
- Subjects
- Aged, Aged, 80 and over, Anthropometry, Female, Humans, Italy epidemiology, Longitudinal Studies, Male, Neoplasms mortality, Proportional Hazards Models, Regression Analysis, Risk Factors, Sex Factors, Body Mass Index, Longevity physiology, Mortality
- Abstract
Background: The role of body mass index (BMI) as a factor influencing longevity of the elderly subject is still under debate., Objective: To evaluate at a population level whether or not BMI is a risk factor of mortality in the elderly, highlighting possible gender-related differences., Methods: 3,282 Subjects aged 65-95 years, were recruited from an Italian general population and 12-year events were recorded. Blood tests and anthropometric measurements were performed. BMI as a continuous item was divided into quintiles and, for each quintile, adjusted hazard ratio (HR) with 95% confidence intervals for mortality was derived by classes of age and gender from Cox analysis., Results: BMI inversely predicted overall and cancer mortality in men only. Overall mortality rate was 64.7% (HR = 1.63 [1.23-2.71]) in the 1st quintile of BMI, 54.9% (1.21 [0.92-1.73]) in the 2nd, 54.1% (1.20 [0.85-1.67]) in the 3rd, 53.3% (1.04 [0.82-1.32]) in the 4th and 52.5% in the 5th; cancer mortality rate was 23.1% (HR = 2.35 [1.31-4.23]), 14.2% (HR = 1.19 [0.65-1.80]), 15.8% (HR = 1.49 [0.93-2.39]), 15.8% (HR = 1.36 [0.84-2.16]) and 13.4%, respectively. The relationship between BMI and mortality remained significant only in men aged 76 years or less. No relationship was found between BMI and coronary or cerebrovascular mortality., Conclusions: BMI <22.7 kg/m2 does not improve survival in the elderly, while it is an independent predictor of cancer mortality in men aged
- Published
- 2007
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