1. Differential expression of TLR2 and TLR4 in α4β7-positive leukocytes of patients with axial spondyloarthritis.
- Author
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Romero-López JP, Gómez-Martínez D, Domínguez-López ML, Jiménez-Zamudio L, Casasola-Vargas JC, Burgos-Vargas R, and García-Latorre E
- Subjects
- Adult, Case-Control Studies, Female, Humans, Integrins metabolism, Leukocyte L1 Antigen Complex metabolism, Male, Receptors, Antigen, T-Cell, gamma-delta metabolism, Monocytes metabolism, Spondylarthropathies metabolism, T-Lymphocyte Subsets metabolism, T-Lymphocytes metabolism, Toll-Like Receptor 2 metabolism, Toll-Like Receptor 4 metabolism
- Abstract
Objectives: Expression of α4β7 integrin can identify gut-homing immune cells. This study aimed to determine the expression of Toll-like receptor 2 (TLR2) and TLR4 in α4β7-positive leukocytes of patients with axial SpA (axSpA)., Methods: We analysed the frequencies of α4β7-positive T cells, Tγδ cells and monocytes in 14 patients with axSpA and 14 healthy controls, together with the expression of TLR2 and TLR4 by flow cytometry. Also, the concentration of faecal calprotectin was measured in all patients and controls., Results: We found significantly higher percentages of α4β7-positive T (P = 0.026) and Tγδ cells (P = 0.0118) in the patients with axSpA than in controls; these cells showed differential expression of TLR2 and TLR4 when compared with α4β7-negative cells. Such differences were not correlated with disease activity or faecal calprotectin concentration., Conclusion: There is an increase in circulating α4β7-positive T and Tγδ cells in patients with axSpA. These cells differentially express TLR2 and TLR4., (© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2020
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