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Your search keyword '"Dou, De-Qiang"' showing total 6 results
Start Over Author "Dou, De-Qiang" Topic molecular structure
6 results on '"Dou, De-Qiang"'

1. Structure elucidation and NMR spectral assignments of one new dammarane-type triterpenoid saponin from black ginseng.

Author

Zhao, Xue-Ting, Dou, De-Qiang, Qu, Yang, and Zhang, Guo-Gang

Subjects
*CHINESE medicine, *HIGH performance liquid chromatography, *NUCLEAR magnetic resonance spectroscopy, *RESEARCH funding, *HERBAL medicine, *THIN layer chromatography, *ANALYTICAL biochemistry, *MOLECULAR structure, *SPECTRUM analysis, *MASS spectrometry, *ELECTROSPRAY ionization mass spectrometry, *GINSENG, *COLLECTION & preservation of biological specimens, *DATA analysis software, *DAMMARANES
Abstract

New dammarane-type triterpenoid saponin, named 22(R)-notoginsenoside Ab1 (1), together with thirteen known dammarane-type triterpenoid saponins (2-14) was isolated from the EtOH extract of black ginseng and their structures were elucidated on the basis of one- and two-dimensional NMR (including 1H-NMR, 13C-NMR, HSQC, HMBC, ROESY) and calculated ECD. Among them, compounds 1-2 and 6-8 were isolated for the first time from ginseng and black ginseng. Besides, the absolute structure of 22(R)- and 22(S)- notoginsenoside Ab1 were distinguished by ECD for the first time. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects

Author

Huang Luqi, Ahmed M. Metwaly, Dou De-qiang, and Zhu Lianlian

Subjects
Phytochemistry, medicine.drug_class, Maltol, Steaming, Pharmaceutical Science, Panax, Secondary Metabolism, Review, Polysaccharide, anticancer, complex mixtures, Anti-inflammatory, Analytical Chemistry, steaming and drying, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, Ginseng, symbols.namesake, 0302 clinical medicine, lcsh:Organic chemistry, Triterpene, Drug Development, Drug Discovery, medicine, Food science, Physical and Theoretical Chemistry, transformed ginsenosides, 030304 developmental biology, anti-inflammatory, chemistry.chemical_classification, 0303 health sciences, Molecular Structure, Organic Chemistry, food and beverages, Saponins, Maillard reaction, chemistry, Chemistry (miscellaneous), black ginseng, 030220 oncology & carcinogenesis, symbols, Molecular Medicine
Abstract

Black ginseng is a type of processed ginseng that is prepared from white or red ginseng by steaming and drying several times. This process causes extensive changes in types and amounts of secondary metabolites. The chief secondary metabolites in ginseng are ginsenosides (dammarane-type triterpene saponins), which transform into less polar ginsenosides in black ginseng by steaming. In addition, apparent changes happen to other secondary metabolites such as the increase in the contents of phenolic compounds, reducing sugars and acidic polysaccharides in addition to the decrease in concentrations of free amino acids and total polysaccharides. Furthermore, the presence of some Maillard reaction products like maltol was also engaged. These obvious chemical changes were associated with a noticeable superiority for black ginseng over white and red ginseng in most of the comparative biological studies. This review article is an attempt to illustrate different methods of preparation of black ginseng, major chemical changes of saponins and other constituents after steaming as well as the reported biological activities of black ginseng, its major saponins and other metabolites.

Published
2019

3. Two new sesquiterpene lactones from leaves of yacon, Smallanthus sonchifolius.

Author

Ran, Xiao-Ku, Win Aung, Khin Khin, Bai, Jun, Dou, Pei-Yuan, Zeng, Zheng, and Dou, De-Qiang

Subjects
HEPATOCELLULAR carcinoma, LEAVES, MEDICINAL plants, MOLECULAR structure, RESEARCH funding, SPECTRUM analysis, PLANT extracts, CYTOTOXINS
Abstract

The chemical constituents of 95% EtOH extract of yacon leaves were separated to yield two new sesquiterpene lactones, together with three known compounds. The two new compounds were characterized to be 8β-angeloyloxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester (1) and 8β-(3-methylbut-2-enoyl) oxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester (2) on the basis of NMR spectra, HR-MS and other spectroscopic methods. The cytotoxicity of compounds 1-5 were evaluated on human hepatoma cell Bel-7402 and all the compounds showed moderate cytotoxicity. [ABSTRACT FROM AUTHOR]

Published
2018
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4. Synthesis of (-)-arctigenin derivatives and their anticancer activity

Author

Chen Gui-rong, Li Fu-Rui, Kang Ting-guo, Dou De-qiang, Li Hong-Fu, Jiang Ning, and Cai Li-ping

Subjects
Synthetic derivatives, Alkylation, Stereochemistry, Cell Survival, Antineoplastic Agents, Plant Science, Butylamines, Biochemistry, Lignans, Analytical Chemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Methylamines, Cell Line, Tumor, Ethylamines, Inhibitory concentration 50, Humans, Furans, Arctigenin, Cell survival, Molecular Structure, Chemistry, Organic Chemistry, Combinatorial chemistry, Arctium, Fruit
Abstract

The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (-)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives were elucidated.

Published
2011

5. Two new compounds from Atractylodes macrocephala with neuroprotective activity.

Author

Zhang, Na, Liu, Chao, Sun, Tie-Min, Ran, Xiao-Ku, Kang, Ting-Guo, and Dou, De-Qiang

Subjects
BIOLOGICAL assay, CHROMATOGRAPHIC analysis, COLORIMETRY, MEDICINAL plants, MOLECULAR structure, NUCLEAR magnetic resonance spectroscopy, RESEARCH funding, PHYTOCHEMICALS, QUANTITATIVE research
Abstract

In the present study, two new compounds, together with six known compounds, were isolated from rhizome ofAtractylodes macrocephalaKoidz by a series of silica gel, ODS column chromatography, and preparative HPLC. Their structures were characterized as atractylenolide II (1), atractylenolide I (2), biepiasterolid (3), isoatractylenolide I (4), atractylenolide III (5), 3β-acetoxyl atractylenolide I (6), (4E,6E,12E)-tetradeca-4,6,12-triene-8,10-diyne-13,14-triol (7), (3S,4E,6E,12E)-1-acetoxy-tetradeca-4,6,12-triene-8,10-diyne-3,14-diol (8) on the basis of 1D, 2D NMR, and circular dichroism analyses. Among them, compounds6and8were novel compounds. In addition, their neuroprotective activity against MPP+-induced SH-SY5Y cells was evaluated by MTT colorimetry. The results showed that all these compounds have definite protective effect on MPP+-induced SH-SY5Y cells. [ABSTRACT FROM PUBLISHER]

Published
2017
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6. Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS.

Author

He Fan, Dou De-Qiang, Sun Yu, Zhu Lin, Xiao Hong-Bin, and Kang Ting-Guo

Subjects
*ANIMAL experimentation, *FRUIT, *HIGH performance liquid chromatography, *LIGNANS, *LIQUID chromatography, *MASS spectrometry, *MOLECULAR structure, *RATS, *RESEARCH funding, *DATA analysis software, *DESCRIPTIVE statistics
Abstract

The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main metabolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. Chromatographic separation was performed on an Agilent™ C18 HPLC column with acetonitrile andwater by linear gradient elution. Arctiin and arctigenin were identified online by LC-MS. The pharmacokinetics and tissue distribution of arctiin and arctigenin were determined for the first time by using a simple, selective, and accurate HPLC method. The AUC0-t values of arctigenin were larger compared with arctiin after oral administration of arctiin. The concentration of the metabolite was significantly higher than the concentration of arctiin in the stomach and small intestine in rats after oral administration of arctiin, indicating that the stomach and small intestine were the major organs of arctiin metabolism. These findings could provide support for the clinical studies conducted with Fructus Arctii. [ABSTRACT FROM AUTHOR]

Published
2012
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