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3,959 results on '"Topoisomerase"'

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1. Investigation of the chromatin remodelling enzyme Uls1 and its interactions with Topoisomerase 2 in S. cerevisiae

2. Mitochondrial topoisomerase I (Top1MT) prevents the onset of metabolic dysfunction-associated steatohepatitis (MASH) in mice.

3. USP37 prevents premature disassembly of stressed replisomes by TRAIP.

4. Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks

5. Role of the Water–Metal Ion Bridge in Quinolone Interactions with Escherichia coli Gyrase

6. Studies Conducted at Johns Hopkins University on Life Science Recently Reported (Using Energy To Go Downhill-a Genoprotective Role for Atpase Activity In Dna Topoisomerase Ii).

7. The hyperthermophilic archaeon Thermococcus kodakarensis is resistant to pervasive negative supercoiling activity of DNA gyrase

8. Discovery of Leishmania donovani topoisomerase IB selective inhibitors by targeting protein-protein interactions between the large and small subunits

9. Regulation of topoisomerase II stability and activity by ubiquitination and SUMOylation: clinical implications for cancer chemotherapy

10. The Effect of Topoisomerase II Beta Mutations on the Transcription/Double-Strand Break Complex

11. Robustadial A and B from <scp> Eucalyptus globulus </scp> Labill. and their anticancer activity as selective <scp>tyrosyl‐DNA</scp> phosphodiesterase 2 inhibitors

12. Evaluation of the target-specific therapeutic potential of herbal compounds for the treatment of cancer

13. Researcher from Karolinska Institute Describes Findings in Pancreatic Cancer (Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription).

15. Microbial Type IA Topoisomerase C-Terminal Domain Sequence Motifs, Distribution and Combination

16. Diversity and Functions of Type II Topoisomerases

17. Molecular docking and molecular dynamics simulation identify a novel Radicicol derivative that predicts exclusive binding to Plasmodium falciparum Topoisomerase VIB

18. Synthesis and Antiproliferative Activity of Some New Coumarin Derivatives Derived from 8-Hydroxycoumarin

19. Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor

20. AraC-FdUMP[10] Is a Next-Generation Fluoropyrimidine with Potent Antitumor Activity in PDAC and Synergy with PARG Inhibition

21. CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells

22. Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases

23. In vitro and in silico assessment of DNA interaction, topoisomerase I and II inhibition properties of chrysosplenetin

24. Molecular dynamics simulations of sulfone derivatives in complex with DNA topoisomerase IIα ATPase domain

25. Anticancer activity and evaluation of apoptotic genes expression of 2-azetidinones containing anthraquinone moiety

26. Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives

27. Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma

28. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells

29. Ribosomal protein S11 influences glioma response to TOP2 poisons

30. N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition

31. Identification of Suppressors oftop-2Embryonic Lethality inCaenorhabditis elegans

32. Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1

33. Proteomic Analysis Reveals that Topoisomerase 2A is Associated with Defective Sperm Head Morphology

34. Stress‐responsive Entamoeba topoisomerase II: a potential antiamoebic target

35. Antibacterial evaluation and molecular docking studies of pyrazole–thiosemicarbazones and their pyrazole–thiazolidinone conjugates

36. Destabilization of FoxM1 and Inhibition of Topoisomerase I Contribute to Cytotoxicity of Prenylated Xanthones Isolated from Metaxya rostrata

37. SCFβ-TrCP-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II

38. Amino acyl tRNA synthetase inhibitors is therapeutics for gliomas at sub nanomolar concentrations

39. Study of the mechanism of action, molecular docking, and dynamics of anticancer terpenoids from Salvia lachnocalyx

40. CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1

41. hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIαin Human Leukemia K562 Cells with Acquired Resistance to Etoposide

42. The Role of Topoisomerase IIβ in the Mechanisms of Action of the Doxorubicin Cardioprotective Agent Dexrazoxane

43. Bioassay Guided Isolation of Topoisomerase Ι Poison from Paphiopedilum callosum (Rchb.f.) Stein

44. Molecular mechanisms of topoisomerase 2 DNA–protein crosslink resolution

45. Novel Tetrazole-Based Antimicrobial Agents Targeting Clinical Bacteria Strains: Exploring the Inhibition of Staphylococcus aureus DNA Topoisomerase IV and Gyrase

46. Role of unique loops in oligomerization and ATPase function of Plasmodium falciparum gyrase B

47. The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, Is Mediated through ROS-Induced Inhibition of HSP-90

48. Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice

49. Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma

50. Findings on Autoimmunity Reported by Investigators at University of Calgary (Activation of the Cgas-sting Innate Immune Response In Cells With Deficient Mitochondrial Topoisomerase Top1mt).

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