1. Mts1 Up-regulation is Associated With Aggressive Pathological Features in Thyroid Cancer
- Author
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Joon-Hyop Lee, Yoo Seung Chung, Ye Won Son, Min Gyeong Cheon, and Ho Hee Jang
- Subjects
Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Biochemistry ,Papillary thyroid cancer ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Internal medicine ,Genetics ,medicine ,Humans ,S100 Calcium-Binding Protein A4 ,Thyroid Neoplasms ,Molecular Biology ,Pathological ,Thyroid cancer ,Retrospective Studies ,business.industry ,Incidence (epidemiology) ,Retrospective cohort study ,medicine.disease ,Up-Regulation ,Thyroid Cancer, Papillary ,Tumor progression ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Female ,Transcriptome ,business ,Research Article - Abstract
Background/aim Thyroid cancer is the most common type of endocrine cancer and its incidence and mortality are increasing. However, few studies on the molecular factors related to its poor prognosis have been performed. The aim of our study was to identify a poor prognostic factor for thyroid cancer to reduce its overtreatment, recurrence, and mortality. Materials and methods The present study is a retrospective study of 55 patients who were diagnosed with papillary thyroid cancer and operated in Korea from September 2013 to November 2015. Results Mts1 is a member of the S100 protein family and is involved in tumor progression and metastasis. Mts1 was highly expressed in patients with thyroid cancer and high Mts1 levels were related to poor prognoses such as lymph node metastasis. Conclusion Mts1 is associated with aggressive pathological features in thyroid cancer, and may be a poor prognostic factor for thyroid cancer.
- Published
- 2019