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Your search keyword '"Ole Eigenbrod"' showing total 2 results
Start Over Author "Ole Eigenbrod" Topic mole rats
2 results on '"Ole Eigenbrod"'

1. Rapid molecular evolution of pain insensitivity in multiple African rodents

Author

Alison J. Barker, Karlien Y. Debus, Gary R. Lewin, Oscar Sánchez-Carranza, Thomas J. Park, Ole Eigenbrod, Nigel C. Bennett, Jane Reznick, Jestina V Katandukila, Georgies F. Mgode, Wei Zhong, Damir Omerbašić, Heike Lutermann, and Daniel W. Hart

Subjects
Pain Threshold, Protein Conformation, Pharmacology, Nociceptive Pain, Evolution, Molecular, Transient receptor potential channel, chemistry.chemical_compound, Species Specificity, Isothiocyanates, Threshold of pain, Animals, TRPA1 Cation Channel, Multidisciplinary, Binding Sites, Chemistry, Sequence Analysis, RNA, Sodium channel, Mole Rats, NAV1.7 Voltage-Gated Sodium Channel, Insect Bites and Stings, Nociceptors, Allyl isothiocyanate, ANT, Capsaicin, Nociceptor, Hydrochloric Acid, Transduction (physiology)
Abstract

How the mole-rat lost its pain Pain alerts our bodies that something is amiss and typically we stop the pain-causing activity. Numerous species of plants and prey animals take advantage of this response by producing pain-causing substances that are released during predation attempts. In turn, species that encounter these substances often evolve ways of turning off the pain-producing mechanism. Eigenbrod et al. searched RNA transcripts in eight species of subterranean rodents related to pain-resistant naked mole-rats. They found multiple changes to ion channels involved in pain across the different species. Understanding such adaptations could elucidate pain mechanisms and help us develop approaches for pain relief. Science , this issue p. 852

Published
2018

2. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

Author

Ole Eigenbrod, Wiebke Hamann, Richard D. Minshall, Tetiana Kosten, Christin Zasada, Victoria M Gavaghan, Michael Gotthardt, Stefan Kempa, Gary R. Lewin, Bethany L. Peterson, John Larson, Heike Lutermann, Nigel C. Bennett, P. Henning J. L. Kuich, Vince G. Amoroso, Thomas J. Park, Ewan St. John Smith, Daniel T. Applegate, Brigitte M. Browe, Michael H. Radke, Vidya Govind, Jane Reznick, Gregory R.C. Blass, Damir Omerbašić, Valérie Bégay, Smith, Ewan St John [0000-0002-2699-1979], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Sucrose, 02 engineering and technology, Fructose, Biology, Fructokinases, 03 medical and health sciences, chemistry.chemical_compound, Mice, Respiration, medicine, Animals, Glycolysis, Anaerobiosis, Lactic Acid, Naked mole-rat, Multidisciplinary, Glucose Transporter Type 5, Mole Rats, Myocardium, Brain, Hypoxia (medical), 021001 nanoscience & nanotechnology, biology.organism_classification, Adaptation, Physiological, Oxygen, 030104 developmental biology, chemistry, Biochemistry, biology.protein, medicine.symptom, 0210 nano-technology, Anaerobic exercise, GLUT5, Phosphofructokinase
Abstract

Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective by Storz and McClelland). These results provide insight into the adaptations that this strange social rodent has to make for life underground. They also have implications for medical practice, particularly for understanding how to protect tissues from hypoxia. Science , this issue p. 307 ; see also p. 248

Published
2017

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