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In this paper, we derive and analyze a mathematical model of a sexual response. As a starting point, we discuss two studies that proposed a connection between a sexual response cycle and a cusp catastrophe and explain why that connection is incorrect but suggests an analogy with excitable systems. This then serves as a basis for derivation of a phenomenological mathematical model of a sexual response, in which the variables represent levels of physiological and psychological arousal. Bifurcation analysis is performed to identify stability properties of the model's steady state, and numerical simulations are performed to illustrate different types of behavior that can be observed in the model. Solutions corresponding to the dynamics associated with the Masters-Johnson sexual response cycle are represented by "canard"-like trajectories that follow an unstable slow manifold before making a large excursion in the phase space. We also consider a stochastic version of the model, for which spectrum, variance, and coherence of stochastic oscillations around a deterministically stable steady state are found analytically, and confidence regions are computed. Large deviation theory is used to explore the possibility of stochastic escape from the neighborhood of the deterministically stable steady state, and the methods of an action plot and quasi-potential are employed to compute most probable escape paths. We discuss implications of the results for facilitating better quantitative understanding of the dynamics of a human sexual response and for improving clinical practice., (© 2023 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).)

A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits clearance of infection, maintenance of a chronic infection, or periodic oscillations. Effects of nucleoside analogues and interferon treatments are analysed, and the critical drug efficiency is determined., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

This paper investigates the effects of vaccination on the dynamics of infectious disease, which is spreading in a population concurrently with awareness. The model considers contributions to the overall awareness from a global information campaign, direct contacts between unaware and aware individuals, and reported cases of infection. It is assumed that there is some time delay between individuals becoming aware and modifying their behaviour. Vaccination is administered to newborns, as well as to aware individuals, and it is further assumed that vaccine-induced immunity may wane with time. Feasibility and stability of the disease-free and endemic equilibria are studied analytically, and conditions for the Hopf bifurcation of the endemic steady state are found in terms of system parameters and the time delay. Analytical results are supported by numerical continuation of the Hopf bifurcation and numerical simulations of the model to illustrate different types of dynamical behaviour., (Copyright © 2017 Elsevier Inc. All rights reserved.)

This paper analyses an SIRS-type model for infectious diseases with account for behavioural changes associated with the simultaneous spread of awareness in the population. Two types of awareness are included into the model: private awareness associated with direct contacts between unaware and aware populations, and public information campaign. Stability analysis of different steady states in the model provides information about potential spread of disease in a population, and well as about how the disease dynamics is affected by the two types of awareness. Numerical simulations are performed to illustrate the behaviour of the system in different dynamical regimes., (Copyright © 2017 Elsevier Inc. All rights reserved.)

In the studies of plant infections, the plant immune response is known to play an essential role. In this paper we derive and analyse a new mathematical model of plant immune response with particular account for post-transcriptional gene silencing (PTGS). Besides biologically accurate representation of the PTGS dynamics, the model explicitly includes two time delays to represent the maturation time of the growing plant tissue and the non-instantaneous nature of the PTGS. Through analytical and numerical analysis of stability of the steady states of the model we identify parameter regions associated with recovery and resistant phenotypes, as well as possible chronic infections. Dynamics of the system in these regimes is illustrated by numerical simulations of the model., (Copyright © 2015 Elsevier Ltd. All rights reserved.)