1. ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease.
- Author
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Murakami M, Shimane K, Takahashi H, Tomiyama J, and Nagashima M
- Subjects
- Adult, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis blood, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis genetics, Antibodies, Antineutrophil Cytoplasmic blood, Antibodies, Antineutrophil Cytoplasmic immunology, Azathioprine therapeutic use, Drug Therapy, Combination, Female, Genetic Predisposition to Disease, Glucocorticoids therapeutic use, HLA-DR Serological Subtypes genetics, Humans, Immunosuppressive Agents therapeutic use, Methylprednisolone therapeutic use, Mixed Connective Tissue Disease blood, Mixed Connective Tissue Disease genetics, Myeloblastin blood, Myeloblastin immunology, Peroxidase blood, Peroxidase immunology, Prednisolone therapeutic use, Pulse Therapy, Drug, Risk Factors, Treatment Outcome, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis complications, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis pathology, Mixed Connective Tissue Disease complications, Mixed Connective Tissue Disease pathology
- Abstract
We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admission to hospital with fervescence, polyarthralgia, purpura, and asymmetric numbness of the extremities. Examination of her genetic background revealed that she carried HLA-DR9, which confers risk of both diseases in Japanese populations.
- Published
- 2013
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