1. Effects of a sustained-release form of isosorbide dinitrate on left atrial pressure in dogs with experimentally induced mitral valve regurgitation.
- Author
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Yamamoto Y, Suzuki S, Hamabe L, Aytemiz D, Huai-Che H, Kim S, Yoshiyuki R, Fukayama T, Fukushima R, and Tanaka R
- Subjects
- Animals, Atrial Pressure drug effects, Blood Pressure physiology, Cross-Over Studies, Delayed-Action Preparations administration & dosage, Delayed-Action Preparations therapeutic use, Dog Diseases drug therapy, Dogs, Echocardiography veterinary, Female, Heart Rate physiology, Isosorbide Dinitrate administration & dosage, Isosorbide Dinitrate therapeutic use, Male, Mitral Valve Insufficiency drug therapy, Mitral Valve Insufficiency pathology, Random Allocation, Vasodilator Agents administration & dosage, Vasodilator Agents therapeutic use, Delayed-Action Preparations pharmacology, Dog Diseases pathology, Isosorbide Dinitrate pharmacology, Mitral Valve Insufficiency veterinary, Vasodilator Agents pharmacology
- Abstract
Background: The effects of isosorbide dinitrate (ISDN) have not been sufficiently investigated in conscious dogs with mitral valve regurgitation (MR)., Objective: The objective was to investigate the effects of a sustained-release form of ISDN (sr-ISDN) on hemodynamics and the autonomic nervous system in dogs with MR., Animals: Six healthy Beagles weighing 11.2 ± 2.2 kg (2 years of age; 2 males and 4 females) were used., Methods: Experimental, crossover, and interventional study. Dogs with experimentally induced MR were administered placebo, 2, 5, and 10 mg/kg sr-ISDN PO on separate days with a 7-day washout period between randomized dosings. Left atrial pressure (LAP) had been recorded continuously from 30 minutes before administration of sr-ISDN to 12 hours after administration., Results: LAP was significantly decreased after administration in the 5 and 10 mg/kg groups. Significant decrease was observed at 3 and 4 hours after administration in the 5 mg/kg group. In the 10 mg/kg group, significant decrease was observed at 2, 3, 4, 5, 6, 7, 10, and 11 hours after administration. The lowest value was observed at 4 hours after administration in the 5 and 10 mg/kg groups (20.9 ± 4.2 to 15.9 ± 3.9 mmHg, P < .01, and 21.3 ± 4.0 to 13.6 ± 4.2 mmHg, P < .001)., Conclusions and Clinical Importance: Sustained-release form of ISDN showed significant decrease of LAP in the 5 mg/kg and 10 mg/kg groups, and duration of effect was dose related., (Copyright © 2013 by the American College of Veterinary Internal Medicine.)
- Published
- 2013
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