1. Moistening of misoprostol tablets with acetic acid prior to vaginal administration for mid-trimester termination of anomalous pregnancy: A randomised comparison of three regimens.
- Author
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Yilmaz B, Ertas IE, Kelekci S, Sut N, Mollamahmutoglu L, and Danisman N
- Subjects
- Abortion, Induced adverse effects, Acetic Acid, Administration, Intravaginal, Adult, Congenital Abnormalities, Female, Humans, Pregnancy, Pregnancy Trimester, Second, Abortifacient Agents, Nonsteroidal adverse effects, Abortion, Induced methods, Misoprostol adverse effects
- Abstract
Objective: To compare the efficacy and side effects of three regimens of intravaginal misoprostol for second-trimester abortion., Methods: A total of 118 women requiring second-trimester pregnancy termination were randomly assigned to one of three treatment groups: 400 microg 3-hourly in group A (n = 39), 600 microg 6-hourly in group B (n = 39), and 800 microg 12-hourly in group C (n = 40). Misoprostol tablets moistened with 3 ml of 5% acetic acid were placed into the posterior vaginal fornix., Results: The median induction-abortion times in groups A (8 h [range: 3-64]) and B (9 h [4-81]) were significantly shorter (p < 0.01 and p < 0.05, respectively) than in group C (12.5 [3-72]). Moreover, expulsion rates within 24 hours in groups A (92.3%) and B (92.3%) were significantly higher (p < 0.05 in both cases) than that of group C (75%). Expulsion rate within 48 hours, number of tablets used, number of patients with retained placenta and side effects did not differ between groups., Conclusions: Misoprostol moistened with acetic acid is effective for second-trimester pregnancy termination when given vaginally 3-hourly, 6-hourly or 12-hourly. The former two regimens are significantly more effective than the latter.
- Published
- 2010
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