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2 results on '"Lazzarin C"'

1. Randomized study of minocycline and edetic acid as a locking solution for central line (port-a-cath) in children with cancer.

Author

Ferreira Chacon JM, Hato de Almeida E, de Lourdes Simões R, Lazzarin C Ozório V, Alves BC, Mello de Andréa ML, Santiago Biernat M, and Biernat JC

Subjects
Anti-Bacterial Agents administration & dosage, Biofilms, Blood microbiology, Catheter-Related Infections epidemiology, Catheter-Related Infections microbiology, Catheterization, Peripheral instrumentation, Catheters, Indwelling, Child, Female, Heparin therapeutic use, Humans, Male, Minocycline administration & dosage, Anti-Bacterial Agents therapeutic use, Catheter-Related Infections drug therapy, Edetic Acid therapeutic use, Minocycline therapeutic use, Neoplasms complications
Abstract

Background: Contamination of central catheters is frequent, and biofilm perpetuates infections. Heparin does not protect against infections because it has no antibiotic action. Minocycline and edetic acid (M-EDTA), a potent calcium chelating agent that destroys bacterial and fungal cell membrane and disrupts biofilm, may be an alternative to allow the associated antibiotic to act locally at a high and safe concentration., Methods: Fifty children with cancer and a port-a-cath were followed up: 26 received heparin (group 1) and 24 M-EDTA (group 2). A total of 762 serial prospective blood cultures were obtained, 387 from group 1 and 375 from group 2., Results: In group 1 (heparin), 19 blood cultures were positive, and infection incidence was 73.1% (19/26 ports). In group 2 (M-EDTA), 5 blood cultures were positive, and the incidence rate was 20.8% (5/24 ports)., Conclusion: M-EDTA, compared with heparin, prevents and treats catheter infections, and is a promising alternative to decrease sepsis during chemotherapy., (Copyright © 2011 S. Karger AG, Basel.)

Published
2011
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2. Randomized Study of Minocycline and Edetic Acid as a Locking Solution for Central Line (Port-A-Cath) in Children with Cancer

Author

Emília Hato de Almeida, Julieta Maria Ferreira Chacon, Benaia Cândida Alves, Regina de Lourdes Simões, João Carlos Biernat, Viviane Lazzarin C. Ozório, Marcela Santiago Biernat, and Maria Lydia Mello de Andrea

Subjects
Male, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Antibiotics, Minocycline, Catheters, Indwelling, Port (medical), Neoplasms, Catheterization, Peripheral, Drug Discovery, medicine, Humans, Pharmacology (medical), Child, Edetic Acid, Pharmacology, Chemotherapy, Heparin, business.industry, Cancer, General Medicine, biochemical phenomena, metabolism, and nutrition, medicine.disease, Anti-Bacterial Agents, Surgery, Blood, Infectious Diseases, Oncology, Biofilms, Catheter-Related Infections, Female, business, Central venous catheter, medicine.drug
Abstract

Background: Contamination of central catheters is frequent, and biofilm perpetuates infections. Heparin does not protect against infections because it has no antibiotic action. Minocycline and edetic acid (M-EDTA), a potent calcium chelating agent that destroys bacterial and fungal cell membrane and disrupts biofilm, may be an alternative to allow the associated antibiotic to act locally at a high and safe concentration. Methods: Fifty children with cancer and a port-a-cath were followed up: 26 received heparin (group 1) and 24 M-EDTA (group 2). A total of 762 serial prospective blood cultures were obtained, 387 from group 1 and 375 from group 2. Results: In group 1 (heparin), 19 blood cultures were positive, and infection incidence was 73.1% (19/26 ports). In group 2 (M-EDTA), 5 blood cultures were positive, and the incidence rate was 20.8% (5/24 ports). Conclusion: M-EDTA, compared with heparin, prevents and treats catheter infections, and is a promising alternative to decrease sepsis during chemotherapy.

Published
2011

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