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Humanity has always benefited from an intercapillary study in the quantification of natural occurrences in mathematics and other pure scientific fields. Graph theory was extremely helpful to other studies, particularly in the applied sciences. Specifically, in chemistry, graph theory made a significant contribution. For this, a transformation is required to create a graph representing a chemical network or structure, where the vertices of the graph represent the atoms in the chemical compound and the edges represent the bonds between the atoms. The quantity of edges that are incident to a vertex determines its valency (or degree) in a graph. The degree of uncertainty in a system is measured by the entropy of a probability. This idea is heavily grounded in statistical reasoning. It is primarily utilized for graphs that correspond to chemical structures. The development of some novel edge-weighted based entropies that correspond to valency-based topological indices is made possible by this research. Then these compositions are applied to clay mineral tetrahedral sheets. Since they have been in use for so long, corresponding indices are thought to be the most effective methods for quantifying chemical graphs. This article develops multiple edge degree-based entropies that correlate to the indices and determines how to modify them in order to assess the significance of each type., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Tang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)