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Ischia, one active volcano of the Phlegraean Volcanic District, prone to very high risk, is dominated by a caldera formed 55 ka BP, followed by resurgence of the collapsed area. Over the past 3 ka, the activity extruded evolved potassic magmas; only a few low-energy explosive events were fed by less evolved magmas. A geochemical and Sr-Nd-O isotope investigation has been performed on minerals and glass from products of three of such eruptions, Molara, Vateliero, and Cava Nocelle (<2.6 ka BP). Data document strong mineralogical, geochemical, and isotopic heterogeneities likely resulting from mingling/mixing processes among mafic and felsic magmas that already fed the Ischia volcanism in the past. Detailed study on the most mafic magma has permitted to investigate its origin. The mantle sector below Ischia underwent subduction processes that modified its pristine chemical, isotopic, and redox conditions by addition of ≤1 % of sediment fluids/melts. Similar processes occurred from Southeast to Northwest along the Apennine compressive margin, with addition of up to 2.5 % of sediment-derived material. This is shown by volcanics with poorly variable, typical δO mantle values, and Sr/Sr progressively increasing toward typical continental crust values. Multiple partial melting of this modified mantle generated distinct primary magmas that occasionally assimilated continental crust, acquiring more O than Sr. At Ischia, 7 % of Hercynian granodiorite assimilation produced isotopically distinct, K-basaltic to latitic magmas. A SW-NE regional tectonic structure gave these magmas coming from large depth the opportunity to mingle/mix with felsic magmas stagnating in shallower reservoirs, eventually triggering explosive eruptions. [ABSTRACT FROM AUTHOR]