1. Spanish version of the Mattis Dementia Rating Scale-2 for early detection of Alzheimer's disease and mild cognitive impairment.
- Author
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Boycheva, Elina, Bermejo‐Pareja, Félix, Contador, Israel, Fernández‐Calvo, Bernardino, Ramos‐Campos, Francisco, Puertas‐Martín, Verónica, Villarejo‐Galende, Alberto, Fernández-Calvo, Bernardino, Ramos-Campos, Francisco, Puertas-Martín, Verónica, Villarejo-Galende, Alberto, and Bermejo-Pareja, Félix
- Subjects
DEMENTIA ,ALZHEIMER'S disease ,MILD cognitive impairment ,NEUROPSYCHOLOGICAL tests ,MEDICAL care for older people - Abstract
Objective: We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS-2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults.Methods: A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI-single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS-2 (total and subscales) were analysed. The MDRS-2 scores, adjusted by socio-demographic characteristics, were calculated through hierarchical multiple regression analysis.Results: The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p < .001) with the Mini-Mental State Examination. The optimal cut-off point between AD patients and HCs was 124 (sensitivity [Se] = 97% and specificity [Sp] = 95%), whereas 131 (Se = 89%, Sp = 81%) was the optimal cut-off point between MCI and HCs. An optimal cut-off point of 123 had good Se (0.97), but poor Sp (0.56) to differentiate AD and MCI groups. The Memory and Initiation/Perseveration subscales had the highest discriminative capacity between the groups.Conclusions: The MDRS-2 is a reliable and valid instrument for the assessment of cognitive impairment in Spanish older adults. In particular, optimal capacity emerged for the detection of early AD and MCI. Copyright © 2017 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2018
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